A Redox-induced Dual-mode Colorimetric and Fluorometric Method based on N-CDs and MnO2 for Determination of Isoniazid in Tablets and Plasma Samples

Ma, Kuanxia; Liang, Lushan; Xie, Zhiyuan; Tan, Weiguo; Hu, Ou; Chen, Zuanguang

doi:10.1016/j.saa.2020.119097

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…These results may suggest that the MnO 2 nanosheets have a layered structure . Atomic force microscopy (AFM) was conducted as shown in the Supporting Information (Figure S2), and it was found that the thickness of the MnO 2 nanosheets in this work was about 2.0 nm, which was in agreement with the literature report . EDS in Figure B suggests the existence of Mn and O.…”

Section: Resultssupporting

confidence: 89%

“…34 Atomic force microscopy (AFM) was conducted as shown in the Supporting Information (Figure S2), and it was found that the thickness of the MnO 2 nanosheets in this work was about 2.0 nm, which was in agreement with the literature report. 35 EDS in Figure 1B suggests the existence of Mn and O. The UV−vis spectrum of MnO 2 solution shows a wide absorption band at 300−500 nm with the maximum absorption peak at 380 nm (Figure 1C).…”

Section: ■ Results and Discussionmentioning

confidence: 96%

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Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO₂ Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Zhao

Shen

Liu

et al. 2021

J. Agric. Food Chem.

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Formaldehyde (HCHO) pollution is a scientific problem of general concern and has aroused wide attention. In this work, a fluorometric method for sensitive detection of formaldehyde was developed based on the oxidase-mimicking activity of MnO2 nanosheets in the presence of o-phenylenediamine (OPD). The MnO2 nanosheets were prepared by the bottom-up approach using manganese salt as the precursor, followed by the exfoliation with bovine serum albumin. The as-prepared MnO2 nanosheets displayed excellent oxidase-mimicking activity, and can be used as the nanoplatform for sensing in fluorometric analysis. OPD was used as a typical substrate because MnO2 nanosheets can catalyze the oxidation of OPD to generate yellow 2,3-diaminophenazine (DAP), which can emit bright yellow fluorescence at the wavelength of 560 nm. While in the presence of formaldehyde, the fluorescence was greatly quenched because formaldehyde can react with OPD to form Schiff bases that decreased the oxidation reaction of OPD to DAP. The main mechanism and the selectivity of the platform were studied. As a result, formaldehyde can be sensitively detected in a wide linear range of 0.8–100 μM with the detection limit as low as 6.2 × 10–8 M. The platform can be used for the detection of formaldehyde in air, beer, and various food samples with good performance. This work not only expands the application of MnO2 nanosheets in fluorescence sensing, but also provides a sensitive and selective method for the detection of formaldehyde in various samples via a new mechanism.

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Section: Resultssupporting

confidence: 89%

Section: ■ Results and Discussionmentioning

confidence: 96%

Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO₂ Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Zhao

Shen

Liu

et al. 2021

J. Agric. Food Chem.

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“…Isoniazid is used for the first-line treatment of tuberculosis, and its overdose leads to liver impairment and even hepatitis . Recently, Chen and his group prepared N-CDs from Liu-bao tea for fluorimetric turn-on determination of isoniazid (INH) . The INH reduces MnO 2 NSs to Mn 2+ to produce a turn-on response by releasing N-CDs into the solution.…”

Section: Sensing Applicationsmentioning

confidence: 99%

Review of 2D MnO₂ Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications

Hiremath

Banerjee

Chatterjee

2022

ACS Appl. Nano Mater.

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In the past decade, a variety of MnO 2 nanostructures have been used in chemosensing applications because of their unique redox properties, structural diversity, and broad absorption band, which makes them good energy acceptors. The most common strategy in Forster (or fluorescence) resonance energy transfer (FRET)-based chemosensing assays is to use low-dimensional fluorescent dots like carbon-based dots, metal dots, and even fluorescent dyes to form donor−acceptor pairs with 2D MnO 2 nanosheets (NSs). This review is a collection of the current library on fluorescent nanodots and MnO 2 NSs-based FRET conjugates as sensing platforms with a focus on highlighting the strategies involved in the detection of various analytes. Commonly, an analyte-triggered redox reaction results in the decomposition of MnO 2 NSs, leading to the release of fluorescent nanodots in solution for the turn-on detection of various reducing species. We intend to elaborately discuss the systematic upgradation of detection strategies involving fluorescent dots@2D MnO 2 NSs. Recently, a cascade of redox reactions was judiciously employed to target several bioanalytes involving a fluorescent dots@MnO 2 NSs FRET conjugate in a selective and sensitive manner. These sensing assays are categorized by the use of different fluorescent nanodots [carbon dots (CDs) and graphene quantum dots (GQDs), polymer dots, metal dots, etc.] with 2D MnO 2 NSs as FRET pairs in different sensing applications. Further, the analytes were categorized as reducing species, oxidants, enzymes, microbes, etc. The focus was paid to the sensing efficiency of the analytical tool. As a part of the study, a brief account of the synthesis of nanodots and MnO 2 NSs, their properties, and the FRET mechanism is also included. In a few cases, the sensing mechanism follows an inner filter effect without a prerequisite of the distance between the fluorophore and quencher units in the sensing of analytes, which are also covered in this collection. The available literature indicates a bright future for these FRET-based contemporary sensing strategies as environmentally benign, cost-effective, label-free techniques, which are discussed in the end.

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“…3,4 The commonly-used methods for INZ determination include photometric analysis, electrochemiluminescence analysis, high performance liquid chromatography (HPLC) analysis and so on. [1][2][3] However, these methods usually require complicated sample pre-treatments, expensive instrument and well-trained operators. This implies that the development of a detection method which provides quick response, simple operation and high sensitivity is of great signicance.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to the selective and strong antibacterial effect against Mycobacterium infection, isoniazid (INZ) is oen chosen as the preferred treatment for tuberculosis, administered in combination with other drugs. 1,2 However, there exists a very ne margin separating therapeutic and lethal dosages. Considering the wide differences in response to treatments across individuals, it is necessary to adjust the dosage of INZ administered by accounting for the INZ content already in the individuals' bodies.…”

Section: Introductionmentioning

confidence: 99%

Novel β-cyclodextrin doped carbon dots for host–guest recognition-assisted sensing of isoniazid and cell imaging

Zhang

Gong

et al. 2022

RSC Adv.

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A Redox-induced Dual-mode Colorimetric and Fluorometric Method based on N-CDs and MnO2 for Determination of Isoniazid in Tablets and Plasma Samples

Cited by 16 publications

References 28 publications

Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO₂ Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO₂ Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Review of 2D MnO₂ Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications

Novel β-cyclodextrin doped carbon dots for host–guest recognition-assisted sensing of isoniazid and cell imaging

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A Redox-induced Dual-mode Colorimetric and Fluorometric Method based on N-CDs and MnO2 for Determination of Isoniazid in Tablets and Plasma Samples

Cited by 16 publications

References 28 publications

Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO2 Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO2 Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Review of 2D MnO2 Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications

Novel β-cyclodextrin doped carbon dots for host–guest recognition-assisted sensing of isoniazid and cell imaging

Contact Info

Product

Resources

About

Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO₂ Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Universal Nanoplatform for Formaldehyde Detection Based on the Oxidase-Mimicking Activity of MnO₂ Nanosheets and the In Situ Catalysis-Produced Fluorescence Species

Review of 2D MnO₂ Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications