A Reference Equation for Normal Standards for VO 2 Max: Analysis from the Fitness Registry and the Importance of Exercise National Database (FRIEND Registry)

Myers, Jonathan; Kaminsky, Leonard A.; Lima, Ricardo Moreno; Christle, Jeffrey W.; Ashley, Euan A.; Arena, Ross

doi:10.1016/j.pcad.2017.03.002

Cited by 154 publications

(148 citation statements)

References 26 publications

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“…Furthermore, unhealthy lifestyle habits like smoking and alcohol drinking which are specific for this tumor type tend to cluster with physical inactivity [29]. The estimated cardiorespiratory fitness level (mean 27.9 ml/kg/min) of patients in this study was lower than the measured VO 2 max of 33.7 ml/kg/min reported in healthy populations [30], but higher than the directly measured VO 2 max of 23.7 ml/kg/min in patients with cancer during or following treatment [31]. However, previous research has shown that submaximal exercise tests, especially in participants with low levels of physical fitness, overestimate the actual measured exercise capacity [32].…”

Section: Discussioncontrasting

confidence: 64%

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

et al. 2019

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Introduction: Objective measurements of levels of physical activity and fitness in patients with head and neck cancer (HNC) are lacking. Furthermore, demographic, clinical and lifestyle-related correlates of low levels of physical activity and fitness in patients with HNC are unknown. This study aims to investigate the levels of accelerometer that assessed physical activity and fitness in patients with HNC and to identify their demographical, clinical and lifestyle-related correlates. Methods: Two hundred and fifty-four patients who were recently diagnosed with HNC and participated in the NETherlands QUality of life and Biomedical cohort studies In head and neck Cancer (NET-QUBIC) study were included. Physical activity (accelerometer), cardiorespiratory fitness (Chester Step Test), hand grip strength (hand dynamometer) and lower body muscle function (30-second chair-stand test) were assessed. Multivariable linear regression analyses with a stepwise forward selection procedure were used. Results: Patients spent 229 min/d in physical activity of which 18 min/d in moderate-to-vigorous physical activity. The mean predicted VO 2 max was 27.9 ml/kg/min, the mean hand grip strength was 38.1 kg and the mean number of standings was 14.3. Patients with lower educational level, more comorbidity and higher tumor stage spent significantly less time in physical activity. Older patients, females and patients with a higher tumor stage had significantly lower cardiorespiratory fitness levels. Older patients, females, patients with more comorbidity, patients with normal weight and patients who have never smoked had significantly lower hand grip strength. Older patients, patients with lower educational level, smokers and patients with more comorbidity had a significantly lower function of lower body muscle. Conclusions: Pre-treatment levels of physical activity, cardiorespiratory fitness and lower body muscle function are low in patients with HNC. Based on this study, exercise programs targeted and tailored to patients with low levels of physical activity and fitness can be developed.

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Section: Discussioncontrasting

confidence: 64%

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

et al. 2019

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“…In addition, TM test approval associated inversely with body weight. Reference equations for TM performance (expressed as VO2 max) indicate that age, body weight, and gender are independent predictors of test result [60], which is in concordance with our findings.…”

Section: Different Exercise Test Modalitiessupporting

confidence: 91%

Exercise Testing in Firefighters : Work Capacity and Cardiovascular Risk Assessment in a Low-Risk Population

Carlén

2019

Linköping University Medical Dissertations

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“…Myers et al ( and Kaminsky et al ( recently published normative values for CPET in separate populations of adults using TM and CE. Although the investigators found generally lower peak

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O 2 values in CE CPET, they were unable to identify a unique conversion factor that could eliminate differences between the two ergometer types across the age groups of their study.…”

Section: Discussionmentioning

confidence: 99%

The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults

et al. 2019

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Cardiopulmonary exercise testing (CPET) modalities, treadmill (TM), and cycle ergometer (CE), influence maximal gas exchange and heart rate (HR) responses. Little is known regarding CPET modality effect on submaximal biomarkers during childhood and adolescence. Ninety‐four healthy participants (7–34 y.o., 53% female) performed TM and CE CPET to address two major gaps: (1) the effect of modality on submaximal CPET biomarkers, and (2) estimation of work rate in TM CPET. Breath‐by‐breath gas exchange enabled calculation of linear regression slopes such as trueV˙O2/ΔHR and ΔtrueV˙E/ΔtrueV˙CO2. Lean body mass (LBM) was measured with dual X‐ray absorptiometry. We tested a novel TM CPET estimate of work rate based on TM velocity2, incline, and body mass (VIM). Like the linear relationship between trueV˙O2 and work rate in CE CPET, trueV˙O2 increased linearly with TM VIM. TM ΔtrueV˙O2/ΔHR was highly correlated with CE (r = 0.92), and each increased substantially with LBM (P < 0.0001 for TM and CE). ΔtrueV˙O2/ΔHR was to a small (~8.7%) but significant extent larger in TM (1.6 mL/min/beat, P = 0.04). In contrast, TM and CE ΔtrueV˙E/ΔtrueV˙CO2 decreased significantly with LBM, supporting earlier observations from CE CPET. For both CE and TM, males had significantly higher ΔtrueV˙O2/ΔHR but lower ΔtrueV˙E/ΔtrueV˙CO2 than females. Novel TM CPET biomarkers such as ΔVIM/ΔHR and ∆trueV˙O2/ΔVIM paralleled effects of LBM observed in CE CPET. TM and CE CPET submaximal biomarkers are not interchangeable, but similarly reflect maturation during critical periods. CPET analysis that utilizes data actually measured (rather than estimated) may improve the clinical value of TM and CE CPET.

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A Reference Equation for Normal Standards for VO 2 Max: Analysis from the Fitness Registry and the Importance of Exercise National Database (FRIEND Registry)

Cited by 154 publications

References 26 publications

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

Exercise Testing in Firefighters : Work Capacity and Cardiovascular Risk Assessment in a Low-Risk Population

The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults

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