A relation between longevity, metabolic rate, and activity in shaker mutants of Drosophila melanogaster

Trout, William E.; Kaplan, William D.

doi:10.1016/0531-5565(70)90033-1

Cited by 90 publications

(39 citation statements)

References 4 publications

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“…Selection for male longevity might lead to selection on other traits, such as locomotory behaviour, metabolic rate and metabolic efficiency. Low rates of metabolism have been previously associated with long life in different taxa [45,46], including invertebrates [47,48], but overall the empirical support for this hypothesis is weak at best [46,49 -51]. Alternatively, selection for improved bioenergetic efficiency could increase lifespan, potentially at the cost of reproduction [52].…”

Section: Resultsmentioning

confidence: 99%

Sexes suffer from suboptimal lifespan because of genetic conflict in a seed beetle

2012

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Males and females have different routes to successful reproduction, resulting in sex differences in lifespan and age-specific allocation of reproductive effort. The trade-off between current and future reproduction is often resolved differently by males and females, and both sexes can be constrained in their ability to reach their sex-specific optima owing to intralocus sexual conflict. Such genetic antagonism may have profound implications for evolution, but its role in ageing and lifespan remains unresolved. We provide direct experimental evidence that males live longer and females live shorter than necessary to maximize their relative fitness in Callosobruchus maculatus seed beetles. Using artificial selection in a genetically heterogeneous population, we created replicate long-life lines where males lived on average 27 per cent longer than in short-life lines. As predicted by theory, subsequent assays revealed that upward selection on male lifespan decreased relative male fitness but increased relative female fitness compared with downward selection. Thus, we demonstrate that lifespan-extending genes can help one sex while harming the other. Our results show that sexual antagonism constrains adaptive life-history evolution, support a novel way of maintaining genetic variation for lifespan and argue for better integration of sex effects into applied research programmes aimed at lifespan extension.

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Section: Resultsmentioning

confidence: 99%

Sexes suffer from suboptimal lifespan because of genetic conflict in a seed beetle

2012

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“…Specifically, hyperkinetic, Hk1, flies have a high metabolic rate, high behavioural activity, reduced longevity, and reduced sensitivity to acrolein stress compared with wild type flies (Trout & Kaplan, 1970;A. R. Barros et a!., personal communication).…”

Section: Discussionmentioning

confidence: 99%

Fluctuating asymmetry: a biological monitor of environmental and genomic stress

1992

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“…It is a prediction of the 'Rate of Living' hypothesis of Pearl (1928) that activity should be inversely related to age at death. Trout & Kaplan (1970) demonstrated just such an effect in the relatively short-lived but hyperactive Drosophila mutant Shaker. The problem in measuring the expression of longevity in mutant lines of D. melanogaster is the marked sensitivity of the phenotype to the external environment, particularly crowding, and effects of genetic background (Lamb, 1978).…”

Section: Effect Of P-cresol On Survivalmentioning

confidence: 99%

The effect of the inactive mutation on longevity, sex, rhythm and resistance to p-Cresol in Drosophila melanogaster

O’Dell

1993

Heredity

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Flies carrying the inactive (jay) mutation exhibit low locomotor activity and poor mating success, both of which are associated with a deficiency in the putative neurotransmitter, octopamine. Several other aspects of the lay mutant phenotype are described here. Male and female iav mutants show a small reduction in longevity but it is not clear whether this is a consequence of the jay mutation or their inactive phenotype. Young jay males show extended attractiveness to older courting males, which supports the notion that the jay gene has a role in post-eclosional maturation. The eclosion rhythm of iav mutants is normal, discounting the possibility of a role for octopamine in the maintenance of circadian rhythm. Flies carrying the jay mutation are highly susceptible to the octopamine analogue p-Cresol. Other phenotypically inactive flies show wild type levels of p-Cresol resistance. This is attributed to the deficiency of octopamine in lay mutants because low octopamine levels may be unable to out-compete the toxic effect of p-Cresol. Some inferences on the possible mode of action of the jay gene product are discussed.

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A relation between longevity, metabolic rate, and activity in shaker mutants of Drosophila melanogaster

Cited by 90 publications

References 4 publications

Sexes suffer from suboptimal lifespan because of genetic conflict in a seed beetle

Sexes suffer from suboptimal lifespan because of genetic conflict in a seed beetle

Fluctuating asymmetry: a biological monitor of environmental and genomic stress

The effect of the inactive mutation on longevity, sex, rhythm and resistance to p-Cresol in Drosophila melanogaster

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