A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids

Hibbeln, Joseph R.; Umhau, John C.; Linnoila, Markku; George, David T.; Ragan, Paul; Shoaf, Susan E.; Vaughan, Michael R.; Rawlings, Robert R.; Salem, Norman

doi:10.1016/s0006-3223(98)00143-7

Cited by 138 publications

(44 citation statements)

References 24 publications

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“…In another trial, a high fish diet intervention as part of a cholesterollowering program resulted in a reduction of aggressive hostility as measured by the Hopkins Symptom Checklist (SCL-90) (Weidner et al, 1992). In an observational study, subjects with a history of impulsive behaviors, plasma DHA were negatively correlated with serotonin and dopamine metabolites in cerebrospinal fluid, suggesting that the dietary intake of DHA may influence neurotransmitter concentrations (Hibbeln et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Dietary intake of n-3, n-6 fatty acids and fish: Relationship with hostility in young adults—the CARDIA study

et al. 2003

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Background: Hostility has been shown to predict both the development and manifestation of coronary disease. Examining the inter-relation of dietary intake of fish and of polyunsaturated (n-3 and n-6) essential fatty acids with hostility may provide additional insights into the cardioprotective effect of dietary fish and polyunsaturated fatty acids. Objective: To examine the association of dietary n-3, n-6 fatty acids and fish with level of hostility in a sample of 3581 urban white and black young adults. Design: Cross-sectional observational study as part of an ongoing cohort study. A dietary assessment in 1992-1993 and measurement of hostility and other covariates in 1990-1991 were used in the analysis. Results: The multivariate odds ratios of scoring in the upper quartile of hostility (adjusting for age, sex, race, field center, educational attainment, marital status, body mass index, smoking, alcohol consumption and physical activity) associated with one standard deviation increase in docosahexaenoic acid (DHA, 22:6) intake was 0.90 (95% CI ¼ 0.82-0.98; P ¼ 0.02). Consumption of any fish rich in n-3 fatty acids, compared to no consumption, was also independently associated with lower odds of high hostility (OR ¼ 0.82; 95% CI ¼ 0.69-0.97; P ¼ 0.02). Conclusions: These results suggest that high dietary intake of DHA and consumption of fish rich in n-3 fatty acids may be related to lower likelihood of high hostility in young adulthood. The association between dietary n-3 fatty acids and hostile personality merits further research.

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Section: Discussionmentioning

confidence: 99%

Dietary intake of n-3, n-6 fatty acids and fish: Relationship with hostility in young adults—the CARDIA study

et al. 2003

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“…Lipids and lipid metabolism have been linked to many disorders, both somatic [9][10][11][12][13][14] and neuropsychiatric [15][16][17][18][19][20][21]. McEwen and Stellar [22] proposed that exposure to frequent and chronic environmental stressors may produce insufficient or overreacting responses, resulting in cumulative damage that physiologic systems have endured in the process of adapting to stressors, increasing the risk of disease.…”

Section: Introductionmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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“…However, drug and diet therapies to lower cholesterol also alter levels of essential fatty acids. Because levels of essential fatty acids predict 5-hydroxyindoleacetic acid levels in cerebrospinal fluid and cholesterol levels do not (170,171), cholesterol levels may be a surrogate marker of changes in essential fatty acids.…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

Diagnostic and Statistical Manual of Mental Disorders

2018

The SAGE Encyclopedia of Intellectual and Developmental Disorders

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Alternative therapies are widely used by consumers. A number of herbs and dietary supplements have demonstrable effects on mood, memory, and insomnia. There is a significant amount of evidence supporting the use of Hypericum perforatum (St. John's wort) for depression and Ginkgo biloba for dementia. Results of randomized, controlled trials also support the use of kava for anxiety and valerian for insomnia. Although evidence for the use of vitamins and amino acids as sole agents for psychiatric symptoms is not strong, there is intriguing preliminary evidence for the use of folate, tryptophan, and phenylalanine as adjuncts to enhance the effectiveness of conventional antidepressants. S-adenosylmethionine seems to have antidepressant effects, and omega-3 polyunsaturated fatty acids, particularly docosahexaenoic acid, may have mood-stabilizing effects. More research should be conducted on these and other natural products for the prevention and treatment of various psychiatric disorders.

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A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids

Cited by 138 publications

References 24 publications

Dietary intake of n-3, n-6 fatty acids and fish: Relationship with hostility in young adults—the CARDIA study

Dietary intake of n-3, n-6 fatty acids and fish: Relationship with hostility in young adults—the CARDIA study

Application of fatty acid and lipid measurements in neuropsychiatry

Diagnostic and Statistical Manual of Mental Disorders

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