A Report–Chronic Fatigue Syndrome: Guidelines for Research

Sharpe, Michael; Archard, L. C.; Banatvala, J. E.; Borysiewicz, Leszek K.; Clare, Anthony W.; David, Anthony; Edwards, R. H. T.; Hawton, Keith; Lambert, H P; Lane, Russell J.M.

doi:10.1177/014107689108400224

Cited by 818 publications

(603 citation statements)

References 13 publications

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“…In total, 641 patients were recruited into the PACE trial from secondary-care specialist CFS clinics in the UK, all of whom met the Oxford criteria for CFS (6 months of disability, with fatigue as a principal symptom, not otherwise explained by other diagnoses) (Sharpe et al 1991). Participants were assessed by a research assistant for the presence of the international CDC criteria for CFS (Reeves et al 2003) and diagnostic criteria for fibromyalgia (Wolfe et al 2010).…”

Section: Methodsmentioning

confidence: 99%

Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial

et al. 2013

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Background. Pain is a common symptom of chronic fatigue syndrome (CFS). We investigated the effects of the treatments used in the PACE trial [cognitive behavioural therapy (CBT), graded exercise therapy (GET), adaptive pacing therapy (APT) and specialist medical care (SMC)] on pain in CFS.Method. We compared pain outcomes including individual painful symptoms, taken from the CDC criteria for CFS and co-morbid fibromyalgia. We modelled outcomes adjusting for baseline variables with multiple linear regression.Results. Significantly less frequent muscle pain was reported by patients following treatment with CBT compared to SMC (mean difference = 0.38 unit change in frequency, p = 0.02), GET versus SMC (0.42, p = 0.01) and GET versus APT (0.37, p = 0.01). Significantly less joint pain was reported following CBT versus APT (0.35, p = 0.02) and GET versus APT (0.36, p = 0.02). Co-morbid fibromyalgia was less frequent following GET versus SMC (0.03, p = 0.03). The effect sizes of these differences varied between 0.25 and 0.31 for muscle pain and 0.24 and 0.26 for joint pain. Treatment effects on pain were independent of 'change in fatigue'.Conclusions. CBT and GET were more effective in reducing the frequency of both muscle and joint pain than APT and SMC. When compared to SMC, GET also reduced the frequency of co-morbid fibromyalgia; the size of this effect on pain was small.

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Section: Methodsmentioning

confidence: 99%

Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial

et al. 2013

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“…The trial included participants meeting the Oxford criteria for CFS [4], which require fatigue as the principal symptom, accompanied by significant disability and without an exclusionary medical or psychiatric diagnosis. All participants were assessed by specialist doctors to exclude other medical diagnoses [18].…”

Section: Entry Criteria and Primary Outcomesmentioning

confidence: 99%

“…It involves comparing the patient's symptoms and history with diagnostic criteria; the Oxford criteria [4], the International 1994 criteria [3], and the National Institute for Health and Care Excellence (NICE) criteria [2].…”

Section: Introductionmentioning

confidence: 99%

Complementary and alternative healthcare use by participants in the PACE trial of treatments for chronic fatigue syndrome

Lewith

Stuart

Chalder

et al. 2016

Journal of Psychosomatic Research

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“…Despite accumulating evidence recognising it as affecting 250,000 people in the UK [4], controversy surrounding this diagnosis is reflected in CFS/ME patient experiences of feeling stigmatised and marginalised [5]. Two main diagnostic criteria commonly used to diagnose CFS/ME [6] are those of the CDC (Centers for Disease Control and Prevention, US) [1] and Oxford [7], with the former most commonly used in the UK [8].…”

Section: Introductionmentioning

confidence: 99%

Enhanced psychological flexibility and improved quality of life in chronic fatigue syndrome/myalgic encephalomyelitis

Densham

Williams

Johnson

et al. 2016

Journal of Psychosomatic Research

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Objective: Psychological Flexibility (PF) is a relatively new concept in physical health. It can be defined as an overarching process of being able to accept the presence of wanted/unwanted experiences, choosing whether to change or persist in behaviour in response to those experiences. Associations between processes of PF and quality of life (QoL) have been found in long-term health conditions such as chronic pain, PF has not yet been applied to Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Methods:Changes in PF, fatigue severity and QoL were examined in one hundred and sixtyfive patients with CFS/ME engaged in a six-week outpatient interdisciplinary group treatment programme. Participants were assessed using a series of self-report measures at the start of the start (T1) and end of a six-week programme (T2) and at six months follow up (T3).Results: Significant changes in PF and QoL were observed from pre-treatment (T1) to post treatment follow-up (T2 and T3); changes in fatigue severity were observed from T1 to T3 only. Controlling for fatigue severity, changes in the PF dimension of activity/occupational engagement were associated with improvement in QoL at six month follow up (T3) but not at six weeks post programme (T2). Conclusion:Findings indicate an interdisciplinary group treatment approach for people with CFS/ME may be associated with improved QoL, processes of PF and fatigue severity, supporting a link between PF and long term health conditions. Results highlight links Running head: Psychological flexibility in CFS/ME 3 between PF and patient QoL in CFS/ME and the value of interdisciplinary treatment approaches in this patient population. Keywords

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A Report–Chronic Fatigue Syndrome: Guidelines for Research

Abstract: Report of a consensus meeting held at Green College.

Cited by 818 publications

References 13 publications

Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial

Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial

Complementary and alternative healthcare use by participants in the PACE trial of treatments for chronic fatigue syndrome

Enhanced psychological flexibility and improved quality of life in chronic fatigue syndrome/myalgic encephalomyelitis

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