A report on the analysis of 365 cases of adverse reactions of Chinese patent drugs for heart cerebrovascular diseases

Xiang, Bin; Peng, Yong; Jiang, Yu‐Gang

doi:10.5897/ajpp12.147

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…injection of Acanthopanax spp. in patients with cerebrovascular disease caused adverse reactions, e.g., rash, papules, nausea, vomiting, and diarrhea ( 19 ). An in vitro study revealed that ADA extracts were not mutagenic and contained anti-mutagenic activities ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Subchronic Oral Toxicity Study of Acanthopanax divaricatus var. albeofructus in Rats

Kim¹,

Lee

et al. 2017

ToxicolRes

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Acanthopanax divaricatus (Siebold & Zucc.) Seem. var. albeofructus (ADA), a traditional medical herb, has been used to treat arthritis and muscular injury, to strengthen muscle and bone, and to get vital energy. However, information regarding its toxicity is limited. ADA was administered by oral gavage to groups of rats at doses of 0 (control), 1,000, 1,500, 2,000, 2,500, and 3,000 mg/kg five times per week for 13 weeks. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, urinalysis, organ weights, necropsy, histopathological finding, vaginal cytology, and sperm morphology were compared between control and ADA-treated groups. Salivation was intermittently observed in both sexes receiving 2,500 and 3,000 mg/kg directly after dosing. Absolute liver weights increased in females receiving 2,000, 2,500, and 3,000 mg/kg ADA (P < 0.05, P < 0.01, and P < 0.01, respectively) and so did the relative liver weights (P < 0.001). Salivation and increased liver weight were ADA-related changes but not considered to be adverse effects. Salivation was intermittent and transient, and the liver weight increase was minor and not accompanied by other changes such as hepatic morphological or functional alterations. The no-observed-adverse-effect-level was determined to be at least 3,000 mg/kg in both sexes of rats.

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Section: Introductionmentioning

confidence: 99%

Subchronic Oral Toxicity Study of Acanthopanax divaricatus var. albeofructus in Rats

Kim¹,

Lee

et al. 2017

ToxicolRes

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“…SMI contains the following herbs: Renshen (Radix Ginseng; Ginseng), Maidong (Radix Ophiopogonis; Dwarf Lilyturf Tuber), and Wuweizi (Fructus schisandrae chinensis ; Chinese Magnoliavine Fruit). The clinical safety of SMI has been speculated, and the adverse effects were detected in 36 patients taking SMI, including 17 male and 19 female [ 2 ]. The main adverse effect for patients taking SMI is anaphylactic reaction [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical safety of SMI has been speculated, and the adverse effects were detected in 36 patients taking SMI, including 17 male and 19 female [ 2 ]. The main adverse effect for patients taking SMI is anaphylactic reaction [ 2 ]. Additionally, clinical drug-drug interaction between SMI and warfarin was also reported [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Inhibition of the Components from Shengmai Injection towards UDP‐Glucuronosyltransferase

Jiang

Zhao

Cao

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The mechanism of shengmai injection- (SMI-) related drug-drug interaction remains unclear. Evaluation of the inhibition potential of SMI's ingredients towards UDP-glucuronosyltransferases (UGTs) activity will provide a new insight to understand SMI-related drug-drug interaction. In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, ophiopogonin D′ (OD′) noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 μM, respectively. In combination with our previous results obtained for the inhibition of UGT isoforms by ginsenosides and wuweizi components, the important SMI ingredients exhibiting strong inhibition towards UGT isoforms were highlighted. All the results obtained in the present study provide a new insight to understand SMI-related drug-drug interaction.

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A report on the analysis of 365 cases of adverse reactions of Chinese patent drugs for heart cerebrovascular diseases

Cited by 2 publications

References 6 publications

Subchronic Oral Toxicity Study of Acanthopanax divaricatus var. albeofructus in Rats

Subchronic Oral Toxicity Study of Acanthopanax divaricatus var. albeofructus in Rats

The Inhibition of the Components from Shengmai Injection towards UDP‐Glucuronosyltransferase

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