We describe development of SAHARA (SISTAS Accessing HIV/AIDS Resources At-a-click), an innovative HIV prevention program that uses a computer to deliver an updated version of SiSTA, a widely used, effective group-level HIV prevention intervention for African American women ages 18-29. Fidelity to SiSTA's core components was achieved using: (1) video clips featuring group discussions and modeling of appropriate sexual-and contraceptive-related behavior; and (2) interactive Flash modules facilitating cognitive rehearsal, providing learning experiences through games and quizzes, and providing opportunities for simulated role-play. A preliminary outcome study of SAHARA conducted at Planned Parenthood, Atlanta, found that SAHARA, when followed by a brief 20-minute wrap-up group session facilitated by a health educator, was effective in promoting consistent condom use for vaginal sex. We discuss the potential advantages and challenges of an intervention like SAHARA delivered by computer to an individual, versus one like SiSTA delivered by a health educator to a small group.HIV prevention efforts have slowed the spread of HIV both in the United States and worldwide and have saved many lives (Card et al., 2007; Centers for Disease Control and Prevention [CDC], 2001; UNAIDS, 2008). Until an effective vaccine is developed, preventing transmission requires the deployment of effective, culturally competent prevention strategies that address one or more routes of transmission, including sex, injection drug use, parent-to-child transmission, and transmission in health care settings.In the past decade and a half, many interventions aimed at preventing the spread of HIV have been put into practice and found effective in changing HIV risk-related behavior. These include individual-level and small group-level interventions that seek to directly influence the knowledge, attitudes, skills, and behaviors of persons who participate in intervention activities; communitty-level interventions that influence the knowledge, attitudes, skills, and behaviors of an entire community both directly and indirectly, often through a focus on changing social norms; and structural interventions that indirectly influence risk behavior by effecting changes to policies, laws, organizational practices, or other structures that are related either to risk behaviors or to access to behavioral prevention information, tools, or services (Card,