A Resected Case of Solitary Pulmonary Capillary Hemangioma Showing Pure Ground Glass Opacity

Abstract

A 53-year-old Japanese woman was referred to our hospital for pure ground glass opacity (GGO) in the left upper lung on computed tomography. 18F-fluorodeoxyglucose positron emission tomography revealed no abnormal uptake in the lesion. After 4 months of follow-up, we strongly suspected the lesion to be a bronchioloalveolar carcinoma and decided to perform a surgery for diagnosis. Planning to perform lingual segmentectomy by videoassisted thoracic surgery (VATS) with mini thoracotomy, we finally performed the left upper lobectomy to guarantee the optimal margin by VATS, because the lesion was not identified by palpation. Final pathological diagnosis was a solitary pulmonary capillary hemangioma (SPCH). We herein report a resected case of SPCH showing pure GGO and review all reported SPCH cases.

Case of solitary pulmonary capillary hemangioma: Pathological features based on frozen section analysis

“…The affected locations were the upper lobe in two cases, the middle lobe in one case, and the lower lobe in nine cases, with tumor sizes ranging from 5 to 20 mm (mean, 10.5 mm). SPCH is characterized as a tumor that tends to appear as a single small lesion in the lower lobe, without any symptoms . According to reports on SPCH, CT revealed pure GGO in four cases and mixed GGO in six cases (Table ).…”

Solitary pulmonary capillary hemangioma presenting with a ground glass opacity: A case report & literature review

“…In terms of radiographic appearance, the following findings were observed on chest CT: 3 cases, pure GGO; 3 cases, mixed GGO; 2 cases, a completely solid nodule; and 1 case, a cystic-solid appearance [ 2 ]. According to the report by Sakaguchi et al, 18F-fluorodeoxyglucose positron emission tomography for SPCH showed no abnormal uptake in the lesion [ 7 ]. Therefore, discriminating SPCH from these differential diagnoses based on imaging findings alone is challenging [ 8 , 9 ].…”

Radiomic Feature Analysis for Distinguishing Solitary Pulmonary Capillary Hemangioma From Lepidic-Predominant Lung Adenocarcinoma in Ground Glass Lung Nodules

“…The increasing incidence of this benign tumor raised the importance of preoperative diagnosis. However, SPCH is characterized by GGNs in CT images and mimics LPA radiographically [1,[3][4][5][6][7][8][9][10][11][12][13]. Even experienced thoracic surgeons and radiologists may regard SPCH as early primary lung cancer.…”

“…However, the nal diagnosis of these indeterminate lung nodules includes not only malignancies but also benign lung tumors [16]. SPCH has been an uncommon benign lung tumor, with only 17 reported cases of surgically resected SPCH before 2018 [1,[3][4][5][6][7][8][9][10][11]. However, 25 more cases have been reported in the last two years [12,13].…”

“…This uncommon disease was rst described in a report of eight autopsies in 2000 as "pulmonary capillary hemangiomatosis-like foci" [2], and the term SPCH was rst used in a report of two surgically resected patients in 2006 [3]. Only 17 cases of surgically resected SPCH have been reported in the English literature before 2018 [1,[3][4][5][6][7][8][9][10][11]. Clinically, SPCH usually presents as a ground-glass nodule (GGN) on chest computed tomography (CT) images, which is similar to the presentation of adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidicpredominant adenocarcinoma (LPA) of the lung [1,[3][4][5][6][7][8][9][10][11][12][13].…”