A resourceful giant: APMV is able to interfere with the human type I interferon system

Silva, Lorena C.F.; Almeida, Gabriel Marchesan; Oliveira, Danilo Bretas de; Dornas, Fábio P.; Campos, Rafael K.; Scola, Bernard La; Ferreira, Paulo César Peregrino; Kroon, Erna Geessien; Abrahão, Jônatas Santos

doi:10.1016/j.micinf.2013.11.011

Cited by 25 publications

(28 citation statements)

References 35 publications

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“…The mimivirus genome has been detected in monkeys and bovines, supporting these findings [47,48]. Recently, it has been shown that APMV is able to interact with the human interferon system, a strong clue that both species share an evolutionary history [49]. It appears that APMV’s ability to enter cells by phagocytosis without identified specific cell receptors, together with its large genome that confers a powerful array of non-essential genes, permits APMV to exploit a larger host range than initially believed [39,49].…”

Section: Amoebas As the Main Host Of Giant Virusesmentioning

confidence: 78%

“…Recently, it has been shown that APMV is able to interact with the human interferon system, a strong clue that both species share an evolutionary history [49]. It appears that APMV’s ability to enter cells by phagocytosis without identified specific cell receptors, together with its large genome that confers a powerful array of non-essential genes, permits APMV to exploit a larger host range than initially believed [39,49]. Lastly, as described in this review, there is ample evidence associating APMV and other mimiviruses with humans, especially regarding pneumonia cases [50-57].…”

Section: Amoebas As the Main Host Of Giant Virusesmentioning

confidence: 99%

“…Reorganization of the actin cytoskeleton and activation of phosphatidylinositol 3-kinases were required for APMV entry [39]. However, although it has been shown that APMV is able to interfere with the IFN system in vertebrate cells, further studies are necessary to understand the mechanisms involved in viral replication in vertebrate phagocytes [49]. …”

Section: Viral Replication Cyclementioning

confidence: 99%

“…Analysis of ‘infected’ macrophages revealed that viral DNA increased following infection, and APMV was seem as cytopathogenic for these cells [39]. Recently, a study investigated whether human peripheral blood mononuclear cells (PBMC) can recognize APMV presence by measuring IFN induction; whether APMV can replicate in these cells; and whether replication of the virus is affected by treatment of cells with IFN type I [49]. The results showed that APMV is able to replicate in human PBMC and induce type I IFN in these cells and that it inhibits some IFN-stimulated genes (ISG) by a mechanism that is independent of viroceptors and STAT dephosphorylation [49].…”

Section: Clinical Significancementioning

confidence: 99%

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Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries

Abrahão

Dornas

Silva

et al. 2014

Virol J

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In 2003, Acanthamoeba polyphaga mimivirus (APMV) was first described and began to impact researchers around the world, due to its structural and genetic complexity. This virus founded the family Mimiviridae. In recent years, several new giant viruses have been isolated from different environments and specimens. Giant virus research is in its initial phase and information that may arise in the coming years may change current conceptions of life, diversity and evolution. Thus, this review aims to condense the studies conducted so far about the features and peculiarities of APMV, from its discovery to its clinical relevance.

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Section: Amoebas As the Main Host Of Giant Virusesmentioning

confidence: 78%

Section: Amoebas As the Main Host Of Giant Virusesmentioning

confidence: 99%

Section: Viral Replication Cyclementioning

confidence: 99%

Section: Clinical Significancementioning

confidence: 99%

See 2 more Smart Citations

Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries

Abrahão

Dornas

Silva

et al. 2014

Virol J

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“…This is also of public-health interest, since oysters are eaten by humans and have a high content of nutrients such as minerals (phosphorus, calcium, iron and iodine), glycogen, vitamins (A, B1, B2, C and D) and protein [28]. There is increasing evidence that APMV might play a role as a pathogen of humans and other vertebrate [9,26,29], and our results therefore raise concerns about the possibility of oysters being a possible source of APMV infection when consumed by humans.…”

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confidence: 99%

Oysters as hot spots for mimivirus isolation

et al. 2014

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Viruses are ubiquitous organisms, but their role in the ecosystem and their prevalence are still poorly understood. Mimiviruses are extremely complex and large DNA viruses. Although metagenomic studies have suggested that members of the family Mimiviridae are abundant in oceans, there is a lack of information about the association of mimiviruses with marine organisms. In this work, we demonstrate by molecular and virological methods that oysters are excellent sources for mimiviruses isolation. Our data not only provide new information about the biology of these viruses but also raise questions regarding the role of oyster consumption as a putative source of mimivirus infection in humans.

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Mimiviruses: Replication, Purification, and Quantification

et al. 2016

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The aim of this protocol is to describe the replication, purification, and titration of mimiviruses. These viruses belong to the Mimiviridae family, the first member of which was isolated in 1992 from a cooling tower water sample collected during an outbreak of pneumonia in a hospital in Bradford, England. In recent years, several new mimiviruses have been isolated from different environmental conditions. These giant viruses are easily replicated in amoeba of the Acanthamoeba genus, its natural host. Mimiviruses present peculiar features that make them unique viruses, such as the particle and genome size and the genome's complexity. The discovery of these viruses rekindled discussions about their origin and evolution, and the genetic and structural complexity opened up a new field of study. Here, we describe some methods utilized for mimiviruses replication, purification, and titration. © 2016 by John Wiley & Sons, Inc.

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A resourceful giant: APMV is able to interfere with the human type I interferon system

Cited by 25 publications

References 35 publications

Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries

Acanthamoeba polyphaga mimivirus and other giant viruses: an open field to outstanding discoveries

Oysters as hot spots for mimivirus isolation

Mimiviruses: Replication, Purification, and Quantification

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