As a common disturbance to the railway pantograph-catenary system, the crosswind may deteriorate the current collection quality and threat operational safety. The main topic of this paper is to study the effect of crosswind on the interaction performance of pantograph-catenary considering the aerodynamic forces acting on both the pantograph and catenary. The pantograph-catenary system of the Chengdu-Chongqing passenger special railway is adopted as the analysis object. The absolute nodal coordinate formulation (ANCF) is employed to build the catenary model, of which the numerical accuracy is validated via the comparison with the field measurement data collected from an inspection vehicle operating at 378 km/h. A special spatial grid is defined for the pantograph-catenary system to generate the stochastic wind field based on the empirical spectrum. According to the quasi-steady theory, the wind load acting on the catenary is derived. Computational fluid dynamics (CFD) is employed to calculate the lift and drag forces acting on each component of the pantograph, which are used to derive the equivalent aerodynamic force that can be applied in the lumped-mass model. The simulation results indicate that the pantograph-catenary system of Chengdu-Chongqing passenger special railway has an acceptable performance with a crosswind speed of 20 m/s. But when the crosswind increases up to 30 m/s, some contact force statistics exceed the safety threshold with a turbulence intensity of more than 17%. Through the analysis of the operational safety, it is found that the contact wire always works within the safety range of the pantograph head with a crosswind speed of 30 m/s. But some safety issues can be seen from the maximum uplift of the pantograph head with a turbulence intensity of more than 21%.