A response to Richards and Schulting

Milner, Nicky; Craig, Oliver E.; Bailey, Geoff; Andersen, Søren H.

doi:10.1017/s0003598x00093777

Cited by 24 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sulphur isotopes may add important new data to help us better understand the nature of the Mesolithic/Neolithic transition in Europe and especially in tracking the possible input of fish into Neolithic diets (e.g., see Milner et al, 2004Milner et al, , 2006Richards and Schulting, 2006).…”

Section: Discussionmentioning

confidence: 99%

Sulphur isotope evidence for freshwater fish consumption: a case study from the Danube Gorges, SE Europe

Nehlich

Borić

Stefanović

et al. 2010

Journal of Archaeological Science

150

135

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Sulphur isotope evidence for freshwater fish consumption: a case study from the Danube Gorges, SE Europe

Nehlich

Borić

Stefanović

et al. 2010

Journal of Archaeological Science

150

135

View full text Add to dashboard Cite

“…[133] Serum TNFα levels are Gly148Arg polymorphism in the gp130 gene (IL6ST) was more elevated in patients with hyperandrogenism [98] and PCOS, [134] but frequent in controls compared with hyperandrogenic patients, and in our experience, confirmed by other authors, no association has controls carrying Arg148 alleles had lower 11-deoxycortisol and been observed between common polymorphisms in its gene (TNF) 17-hydroxyprogesterone concentrations, a lower response of anand hyperandrogenism or PCOS. [97,98] However, when considering drostenedione to 1-24 adrenocorticotropin, and an almost signifhyperandrogenic patients and healthy controls as a whole, carriers icant decrease in free testosterone levels. [101] As occurred with the of TNF -308A alleles presented with increased basal and IL6 variants described in section 3.3.3, the wild-type allele was leuprolide-stimulated serum androgens and 17-hydroxyprogesterassociated with hyperandrogenism, whereas the uncommon one levels, suggesting that this variant contributes to hyperanArg148 allele in gp130 had a protective effect against androgen drogenism.…”

Section: Il-6 Signal Transducer Gp130 (Il6st) 331 Tumor Necrosis Famentioning

confidence: 99%

Genetic Basis of Metabolic Abnormalities in Polycystic Ovary Syndrome

Roldán

Millán

Escobar-Morreale

2004

American Journal of PharmacoGenomics

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder characterized by hyperandrogenism and chronic anovulation. The syndrome is frequently associated with an increased risk for insulin resistance and type 2 diabetes mellitus; obesity exacerbates insulin resistance and favors the progression from impaired glucose tolerance to diabetes in these patients. In young women, precocious pubarche and hyperinsulinemia are early manifestations of PCOS. The familial clustering of women with PCOS suggests that heredity is implicated in the origin of the syndrome. However, genetic approaches to its pathogenesis have been hampered by the heterogeneity of phenotypic features within families, and the lack of uniform criteria for diagnosis. Currently, PCOS is considered a polygenic trait that might result from the interaction of susceptibility and protective genomic variants under the influence of environmental factors. Both linkage analysis and association studies are valid tools for the study of the genetics of PCOS. Candidate genes for PCOS include those related to androgenic pathways and metabolic associations of the syndrome. More recently, genes encoding inflammatory cytokines have been identified as target genes for PCOS, as proinflammatory genotypes and phenotypes are also associated with obesity, insulin resistance, type 2 diabetes, PCOS, and increased cardiovascular risk. This paper reviews the candidate genes involved in the metabolic pathways that are altered in patients with PCOS. Despite a significant amount of research in this area, none of the genes studied so far has been identified as the PCOS susceptibility gene for the majority of cases. PCOS is the first component of the metabolic syndrome to be detected in many women, so the identification and correct diagnosis of PCOS has important preventive and therapeutic implications for the affected women and their families. In the future, new therapeutic approaches to PCOS will rely on knowing the genes, environmental influences, and etiologic mechanisms associated with the disorder.

show abstract

“…Similarly, wild animal species continued to form a regular, albeit minor, component of Neolithic faunal assemblages (Thomas 1999, 26). The role of fish in Early Neolithic diet remains a contentious issue (eg, Richards & Hedges 1999;Milner et al 2004;Richards & Schulting 2006;Milner et al 2006) but should be considered as a possibility at least; the balance of the evidence to date suggests a range of dietary adaptations in the Early Neolithic, perhaps including consumption of marine foods (Milner et al 2004;Milner 2010).…”

Section: Aspects Of Technology and Constructionmentioning

confidence: 99%

Early Neolithic Trackways in the Thames Floodplain at Belmarsh, London Borough of Greenwich

Hart¹,

Allott²,

Bamforth³

et al. 2015

Proc. Prehist. Soc.

View full text Add to dashboard Cite

Excavations in 2008 on the site of a proposed new prison at Belmarsh West, London Borough of Greenwich, found the heavily decayed remains of two superimposed Early Neolithic trackways. These structures, which are radiocarbon dated to the first quarter of the 4th millennium cal BC comprise some of the earliest structures yet encountered in the London Basin. The trackways were found towards the base of a peat sequence, immediately above the underlying Devensian gravels. The associated palaeoenvironmental record suggests that they were constructed in response to rising base levels, within a local floodplain environment dominated by alder carr, in order to maintain mobility across an expanding wetland landscape. The archaeological and geomorphological background to the excavations and a description of the results of the excavations are presented, with a particular emphasis on the Neolithic structures. The significance and wider context of the structures are examined through a consideration of their construction, wider palaeoenvironmental context, and the ways in which the structures can shed light on the nature of Early Neolithic subsistence strategies and land-use within the Thames floodplain.

show abstract

A response to Richards and Schulting

Cited by 24 publications

References 30 publications

Sulphur isotope evidence for freshwater fish consumption: a case study from the Danube Gorges, SE Europe

Sulphur isotope evidence for freshwater fish consumption: a case study from the Danube Gorges, SE Europe

Genetic Basis of Metabolic Abnormalities in Polycystic Ovary Syndrome

Early Neolithic Trackways in the Thames Floodplain at Belmarsh, London Borough of Greenwich

Contact Info

Product

Resources

About