A resveratrol-loaded nanostructured lipid carrier hydrogel to enhance the anti-UV irradiation and anti-oxidant efficacy

Liu, Miao; Liu, Daozhou; Cheng, Ying; Mei, Qibing; Zhou, Siyuan

doi:10.1016/j.colsurfb.2021.111786

Cited by 29 publications

(14 citation statements)

References 34 publications

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“…We further tested the (Figure 8A) and GSH (Figure 8B) contents in the neural stem cells to verify its cellular antioxidant mechanism. SOD is an important member of the antioxidant enzyme system scavenging free radicals and active oxygen, while GSH play a key role in regulating immunity 42,43 . The higher the level of SOD and GSH in cells, the stronger the ability to remove reactive oxygen species.…”

Section: Resultsmentioning

confidence: 99%

“…SOD is an important member of the antioxidant enzyme system scavenging free radicals and active oxygen, while GSH play a key role in regulating immunity. 42,43 The higher the level of SOD and GSH in cells, the stronger the ability to remove reactive oxygen species. Both SOD and GSH values of CA-CS hydrogel are higher than the pure CS hydrogel, indicating that the introduction of citric acid does increase the antioxidant effect, which is consistent with the survival rate of cells under oxidative stress conditions.…”

Section: Oxidative Stress In Cellsmentioning

confidence: 99%

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Citric acid cross‐linked chitosan for inhibiting oxidative stress after nerve injury

Liu

Dai

2022

J Biomed Mater Res

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Scaffold design is particularly important and necessary for soft tissue repair such as nerve tissue repair. In this article, we designed and manufactured a macroporous chitosan‐based hydrogel with excellent cell compatibility and antioxidant properties. Here, the chitosan (CS) based hydrogel is obtained by repeated freezing and thawing using citric acid (CA) as a cross‐linking agent. We have evaluated the effects of citric acid content on the physical and chemical properties of hydrogels through mechanical properties and scanning electron microscopy. CA‐CS hydrogel shows a macroporous structure, as the citric acid increases, the mechanical strength increases and the pore size decreases. In vitro cell experiments show that CA‐CS hydrogel partakes positive effects on cell survival, adhesion and proliferation, as well as antioxidant properties. All results provide a basis for the construction of porous chitosan‐based hydrogels, while demonstrating a promising approach to deal with oxidative stress in nerve injury.

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Section: Resultsmentioning

confidence: 99%

Section: Oxidative Stress In Cellsmentioning

confidence: 99%

Citric acid cross‐linked chitosan for inhibiting oxidative stress after nerve injury

Liu

Dai

2022

J Biomed Mater Res

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“…Many active ingredients of TCM have been co-loaded into NLCs to improve the treatment effects, including celastrol, 83 gambogic acid, 84 triptolide, 85 resveratrol, 86 and so on. Notably, a higher drug loading capacity of NLCs was found than liposomes and SLNs.…”

Section: Nano-drug Delivery Systems For Tcmmentioning

confidence: 99%

“…79 NLCs have desirable loading capacity and greater drug accumulation capacity, and are less likely to expel drugs during storage. [80][81][82] Many active ingredients of TCM have been co-loaded into NLCs to improve the treatment effects, including celastrol, 83 gambogic acid, 84 triptolide, 85 resveratrol, 86 and so on. Notably, a higher drug loading capacity of NLCs was found than liposomes and SLNs.…”

Section: Lipid-based Nanocarriersmentioning

confidence: 99%

Nano-traditional Chinese medicine: a promising strategy and its recent advances

et al. 2022

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“…The major endogenous sources of DNA damage are errors in DNA replication and spontaneous chemical changes produced by ROS, carbonyl stress, and hydrolysis of the glycosylic bonds. Exogenous damage is caused by exogenous agents, such as ultraviolet radiation, ionizing radiation, and various chemicals [ 141 , 142 , 143 , 144 ]. In long-term evolution, organisms have developed a series of DNA damage repair mechanisms, such as DNA repair and DNA damage response (DDR), to maintain genetic integrity [ 142 , 145 , 146 ].…”

Section: Does Tea Affect Sickness Sleep and Maintain Energy Homeostasis?mentioning

confidence: 99%

New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress

Ouyang

Peng

Gong

2022

Foods

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Sleep, a conservative evolutionary behavior of organisms to adapt to changes in the external environment, is divided into natural sleep, in a healthy state, and sickness sleep, which occurs in stressful environments or during illness. Sickness sleep plays an important role in maintaining energy homeostasis under an injury and promoting physical recovery. Tea, a popular phytochemical-rich beverage, has multiple health benefits, including lowering stress and regulating energy metabolism and natural sleep. However, the role of tea in regulating sickness sleep has received little attention. The mechanism underlying tea regulation of sickness sleep and its association with the maintenance of energy homeostasis in injured organisms remains to be elucidated. This review examines the current research on the effect of tea on sleep regulation, focusing on the function of tea in modulating energy homeostasis through sickness sleep, energy metabolism, and damage repair in model organisms. The potential mechanisms underlying tea in regulating sickness sleep are further suggested. Based on the biohomology of sleep regulation, this review provides novel insights into the role of tea in sleep regulation and a new perspective on the potential role of tea in restoring homeostasis from diseases.

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A resveratrol-loaded nanostructured lipid carrier hydrogel to enhance the anti-UV irradiation and anti-oxidant efficacy

Cited by 29 publications

References 34 publications

Citric acid cross‐linked chitosan for inhibiting oxidative stress after nerve injury

Citric acid cross‐linked chitosan for inhibiting oxidative stress after nerve injury

Nano-traditional Chinese medicine: a promising strategy and its recent advances

New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress

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