A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves

Murcia‐Belmonte, Verónica; Coca, Yaiza; Vegar, Celia; Negueruela, Santiago; Romero, Camino de Juan; Valiño, Arturo José; Sala, Salvador; DaSilva, Ronan; Kania, Artur; Borrell, Vı́ctor; Martı́nez, Luis M.; Erskine, Lynda; Herrera, Eloı́sa

doi:10.1016/j.cub.2019.02.052

Cited by 24 publications

(25 citation statements)

References 65 publications

(80 reference statements)

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“…Beyond the olfactory system, the present findings add to the existing literature describing the anatomical organization and functional role of interhemispheric connections in sensory processing [9,10]. Evidence of interhemispheric connectivity between early topographic maps in other sensory modalities than olfaction is scarce: a direct interhemispheric connection between retinae, mediated by contralaterally projecting ganglion cells, was recently identified in vertebrates [76]. This connection is only present at perinatal stages and might underlie the synchronization of bilateral retinal waves during development.…”

Section: Discussionmentioning

confidence: 53%

Interhemispheric connections between olfactory bulbs improve odor detection

et al. 2020

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Interhemispheric connections enable interaction and integration of sensory information in bilaterian nervous systems and are thought to optimize sensory computations. However, the cellular and spatial organization of interhemispheric networks and the computational properties they mediate in vertebrates are still poorly understood. Thus, it remains unclear to what extent the connectivity between left and right brain hemispheres participates in sensory processing. Here, we show that the zebrafish olfactory bulbs (OBs) receive direct interhemispheric projections from their contralateral counterparts in addition to top-down inputs from the contralateral zebrafish homolog of olfactory cortex. The direct interhemispheric projections between the OBs reach peripheral layers of the contralateral OB and retain a precise topographic organization, which directly connects similarly tuned olfactory glomeruli across hemispheres. In contrast, interhemispheric top-down inputs consist of diffuse projections that broadly innervate the inhibitory granule cell layer. Jointly, these interhemispheric connections elicit a balance of topographically organized excitation and nontopographic inhibition on the contralateral OB and modulate odor responses. We show that the interhemispheric connections in the olfactory system enable the modulation of odor response and contribute to a small but significant improvement in the detection of a reproductive pheromone when presented together with complex olfactory cues by potentiating the response of the pheromone selective neurons. Taken together, our data show a previously unknown function for an interhemispheric connection between chemosensory maps of the olfactory system.

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Section: Discussionmentioning

confidence: 53%

Interhemispheric connections between olfactory bulbs improve odor detection

et al. 2020

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“…S9). Interestingly, the ventrally enriched gene Unc5c was reported earlier this year to be specific to the ventral retina and play a role in RGC axon guidance (Murcia-Belmonte et al, 2019).…”

Section: Central-to-peripheral Gradients Unveil Axon Guidance Ligand-mentioning

confidence: 98%

Single-cell transcriptional logic of cell-fate specification and axon guidance in early born retinal neurons

et al. 2019

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Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine cells are the first classes of neurons produced in the retina. However, an important question is how this diversity of cell states is transcriptionally produced. Here, we profiled 6067 single retinal cells to provide a comprehensive transcriptomic atlas showing the diversity of the early developing mouse retina. RNA velocities unveiled the dynamics of cell cycle coordination of early retinogenesis and define the transcriptional sequences at work during the hierarchical production of early cell-fate specification. We show that RGC maturation follows six waves of gene expression, with older-generated RGCs transcribing increasing amounts of guidance cues for young peripheral RGC axons that express the matching receptors. Spatial transcriptionally deduced features in subpopulations of RGCs allowed us to define novel molecular markers that are spatially restricted. Finally, the isolation of such a spatially restricted population, ipsilateral RGCs, allowed us to identify their molecular identity at the time they execute axon guidance decisions. Together, these data represent a valuable resource shedding light on transcription factor sequences and guidance cue dynamics during mouse retinal development.

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“…Using eGFP to label small populations of RGCs in the mouse retina, the existence of RGC axons that project normally into the contralateral optic nerve and reach the contralateral retina was demonstrated unequivocally during the perinatal period. These axons originate in the ventronasal retina and, in the opposite eye, their axons come in close contact to starburst amacrine cells [147]. However, further work is required to further explore the interaction of retina-retina axons and amacrine cells.…”

Section: Guidance Mechanisms At the Optic Chiasm Important For Symmentioning

confidence: 99%

Wiring the Binocular Visual Pathways

Murcia‐Belmonte

Erskine

2019

IJMS

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Retinal ganglion cells (RGCs) extend axons out of the retina to transmit visual information to the brain. These connections are established during development through the navigation of RGC axons along a relatively long, stereotypical pathway. RGC axons exit the eye at the optic disc and extend along the optic nerves to the ventral midline of the brain, where the two nerves meet to form the optic chiasm. In animals with binocular vision, the axons face a choice at the optic chiasm—to cross the midline and project to targets on the contralateral side of the brain, or avoid crossing the midline and project to ipsilateral brain targets. Ipsilaterally and contralaterally projecting RGCs originate in disparate regions of the retina that relate to the extent of binocular overlap in the visual field. In humans virtually all RGC axons originating in temporal retina project ipsilaterally, whereas in mice, ipsilaterally projecting RGCs are confined to the peripheral ventrotemporal retina. This review will discuss recent advances in our understanding of the mechanisms regulating specification of ipsilateral versus contralateral RGCs, and the differential guidance of their axons at the optic chiasm. Recent insights into the establishment of congruent topographic maps in both brain hemispheres also will be discussed.

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A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves

Cited by 24 publications

References 65 publications

Interhemispheric connections between olfactory bulbs improve odor detection

Interhemispheric connections between olfactory bulbs improve odor detection

Single-cell transcriptional logic of cell-fate specification and axon guidance in early born retinal neurons

Wiring the Binocular Visual Pathways

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