A Retrospective Analysis of Surgical Operations on Malignancies of the Ear

Nibu, Kennichi; Kamata, Shinkichi; Kawabata, Kazuyoshi; Takahashi, Hisaaki; Nakamizo, Munenaga; Shimada, Shiro; Hoki, Katsuhumi; Yagi, Katsunori; Uchida, Masaoki

doi:10.3950/jibiinkoka.95.1379

Cited by 3 publications

(1 citation statement)

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“…In general, surgical resection for early disease is used in many institutions and surgical treatment could provide 100% tumor control as demonstrated in one study. 20) In addition, the use of brachytherapy with a high dose rate of 6×6 Gy with weekly interruptions or with a low dose rate of 5×10 Gy could be used for EAC disease. 21) In advanced disease, EAC and ME specimens are difficult to orient and adequate surgical margins are difficult to achieve.…”

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confidence: 99%

Role of Radiotherapy for Squamous Cell Carcinoma of the External Auditory Canal and Middle Ear

Kang

Lee

et al. 2009

J Korean Soc Ther Radiol Oncol

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Purpose: To investigate the role of radiotherapy for squamous cell carcinomas of the external auditory canal and middle ear. Materials and Methods: A series of 35 patients who were treated at a single institution from 1981 through 2007 were retrospectively analyzed. Thirteen patients were treated by radiotherapy alone; four by surgery only and 18 by a combination of surgery and radiotherapy. The total radiation dose ranged from 39∼70 Gy (median, 66 Gy) in 13∼35 fractions for radiotherapy alone and 44∼70 Gy (median, 61.2 Gy) in 22∼37 fractions for the combined therapy. Clinical end-points were the cause of specific survival (CSS) and local relapse-free survival (LRFS). The median follow-up time was 2.8 years (range, 0.2∼14.6 years). Results: The 3-year CSS and LRFS rate was 80% and 63%, respectively. Based on a univariate analysis, performance status and residual disease after treatment had a significant impact on CSS; performance status and histologic grade for LRFS. Patients treated by radiotherapy alone had more residual disease following the course of treatment compared to patients treated with the combined therapy; 69% vs. 28%, respectively. Conclusion: Our results suggest that radiation alone was not an inferior treatment modality for CSS compared to the combined therapy for squamous cell carcinoma of the external auditory canal and middle ear. However, local failure after radiotherapy is the main issue that will require further improvement to gain optimal local control.

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confidence: 99%