Middle Ear Carcinoma Originating from a Primary Acquired Cholesteatoma: A Case Report

Takahashi, Kuniyuki; Yamamoto, Yoshiharu; Sato, Katsuro; Sato, Yuichiro; Takahashi, Sugata

doi:10.1097/00129492-200501000-00019

Cited by 15 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A few cases of cholesteatoma‐related carcinoma have been reported; however, a causal association between cholesteatoma and carcinoma remains to be identified. Is cholesteatoma a premalignant or malignant neoplasm?…”

Section: The True Nature Of Cholesteatoma Has Yet To Be Determinedmentioning

confidence: 99%

Etiopathogenesis of acquired cholesteatoma: Prominent theories and recent advances in biomolecular research

2014

View full text Add to dashboard Cite

show abstract

Section: The True Nature Of Cholesteatoma Has Yet To Be Determinedmentioning

confidence: 99%

Etiopathogenesis of acquired cholesteatoma: Prominent theories and recent advances in biomolecular research

2014

View full text Add to dashboard Cite

show abstract

“…14 A total of six cases (five from the literature in addition to the current case report) of SCCTB associated with cholesteatomas are reported in the literature ( Table 1 ). 3 4 8 15 16…”

Section: Discussionmentioning

confidence: 99%

“…1 A few reports have implicated cholesteatoma as an etiologic factor for SCCTB. 2 3 4 5 However, a direct association between both entities (i.e., progression from cholesteatoma to squamous cell carcinoma [SCC]) remains unproven.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Temporal Bone Arising from Cholesteatoma: A Case Report and Review of the Literature

et al. 2022

View full text Add to dashboard Cite

Objective Present a case of squamous cell carcinoma of the temporal bone (SCCTB) arising in a 61-year-old female with a prior history of cholesteatoma and persistent otologic symptoms and review the current literature regarding this disease presentation. Setting Tertiary academic center. Patient A 61-year-old female with a history of left ear cholesteatoma for which she had undergone surgery 54 years prior. The patient presented with a persistent history of otorrhea since first surgery and developed exacerbation of symptoms just prior to presentation at our department. The clinical picture was highly suspicious of cholesteatoma recurrence. However, the biopsy was consistent with squamous cell carcinoma. Intervention Surgical debulking of the lesion was followed by a brief course of radiation therapy later halted by the patient due to side effect intolerance. Conclusion SCCTB may arise from cholesteatoma. A high index of suspicion for SCCTB should be maintained in patients with a prior history of cholesteatoma and evidence of a temporal bone mass with persistent otologic symptoms.

show abstract

“…It is impossible to determine whether the diagnosis of cholesteatoma was a misdiagnosed SCC or represented a concomitant cholesteatoma with TB SCC. Concomitant cholesteatoma and TB SCC were reported in the literature 30,31 ; it was hypothesized that the former may trigger the latter 32 . PEH may occur in the setting of acute and chronic inflammation of the EAC 21,29 .…”

Section: Discussionmentioning

confidence: 99%

Invasion Patterns of External Auditory Canal Squamous Cell Carcinoma: A Histopathology Study

et al. 2020

View full text Add to dashboard Cite

Objectives/Hypothesis To describe the histopathology of the invasion patterns of advanced‐stage external auditory canal (EAC) squamous cell carcinoma (SCC). Study Design Retrospective cohort study. Methods Retrospective analysis of medical records of patients diagnosed with EAC SCC available at the Massachusetts Eye and Ear temporal bone (TB) collection. TBs underwent processing for histologic examination. Hematoxylin and eosin–stained slides were examined. Histologic findings were compared to premortem clinical data. Results Nine TBs were identified. Male:female ratio was 6:3. The average age of diagnosis and duration of survival was 64 (46–80 years) and 2.3 years (1–50 months), respectively. All presented with T4 disease, most commonly due to petrous apex (PA) invasion and facial nerve (FN) weakness. The mastoid air cells system served as a tumor conduit to the tegmen mastoideum and overlying dura in four patients, posterior fossa dura in one patient, vertical segment of FN in four patients, and middle ear (ME) and lateral semicircular canal in five patients. The tumor did not penetrate the tympanic membrane, oval window membrane (fenestra vestibule), or round window (RW) membrane. Supra‐ and infralabyrinthine pneumatization patterns allowed direct routes to the PA. Translabyrinthine PA invasion was seen in two patients. The most common locus of otic capsule invasion was the cochlea. One patient had FN paralysis due to compression rather than invasion. Conclusions SCC does not tend to extend from the ME to the inner ear through the RW and vestibule‐stapedial ligament. Tumors tend to spread along the preexisting TB air‐tract routes. Well‐aerated TB, may facilitate extension to the PA. Level of Evidence 4 Laryngoscope, 131:E590–E597, 2021

show abstract

Middle Ear Carcinoma Originating from a Primary Acquired Cholesteatoma: A Case Report

Abstract: Because middle ear carcinoma has a poor prognosis, it is important to detect lesions early. It is necessary to consider that middle ear carcinoma arises from not only chronic otitis media or surgical invasion but also from primary acquired cholesteatoma.

Cited by 15 publications

References 13 publications

Etiopathogenesis of acquired cholesteatoma: Prominent theories and recent advances in biomolecular research

Etiopathogenesis of acquired cholesteatoma: Prominent theories and recent advances in biomolecular research

Squamous Cell Carcinoma of the Temporal Bone Arising from Cholesteatoma: A Case Report and Review of the Literature

Invasion Patterns of External Auditory Canal Squamous Cell Carcinoma: A Histopathology Study

Contact Info

Product

Resources

About