A retrospective analysis of survival and prognostic factors of male breast cancer from a single center

Abstract

BackgroundLess than 1% of all breast cancer cases are found in men, who reportedly have inferior outcomes compared with matched women patients. Ethnic differences may also affect their prognosis. Here, we investigated overall survival (OS) and major prognostic factors for male breast cancer (MBC) in a cohort of Egyptian patients.MethodsWe retrospectively analyzed OS in a cohort of 69 male patients with MBC who were surgically treated at the Mansoura Cancer Center, Egypt between 2000 and 2007. We registered demographic data, age, height, weight and body mass index, tumor size, histology, number of infiltrated axillary lymph nodes, hormone receptor (HR) status and metastatic presence, and TNM staging. Patients’ OS was the primary endpoint. Patients received treatment to the medical standards at the time of their diagnosis.ResultsIn the 69 patients who met the inclusion criteria and had complete stored patient data, tumors ranged from T1c to T3. We could gather cancer-related survival data from only 56 patients. The collective 5-year survival in this cohort was 46.4%. Only five patients had distant metastasis at diagnosis, but they showed a null percent 5-year survival, whereas those with no lymph node infiltration showed a 100% 5-year survival. Lymph node status and tumor grading were the only prognostic factors that significantly affected OS.ConclusionsLymph node status and tumor grade are the most important prognostic factors for overall survival of MBC in Egyptian male patients; whereas even remarkably low HR expression in MBC did not significantly affect OS. Further research is needed to understand the factors that affect this disease.

Male Breast Cancer: a 24 Year Experience of a Tertiary Care Hospital in Pakistan

“…Our average age at diagnosis was slightly younger than that mentioned in Western literature but was similar to reports from India, Egypt and Iran. (Shah et al, 2012;Sedighi et al, 2013;Soliman et al, 2014) Hyperestrogenism caused by liver failure secondary to infectious etiologies has been considered as a cause of relatively higher rates of MBC in developing regions of the world. (Kaushik et al, 2014) This can be one possible cause of a younger age at diagnosis in these studies.…”

Male Invasive Breast Carcinoma: Nine Years Experience at a Single Center in Turkey

“…Nodal involvement varies from 20.7% to 77.2% (8,12,14,(17)(18)(19)(20)(21). Almost half of the cases showed lymph node metastasis, 53.3%, in our series.…”

“…Although the percentage was the highest among those published series before, the majority of the cases (18/22) were classified to grade 2 (81.8%), as well (12,17,19). Furthermore, there was no grade 1 tumor in the current series.…”

Male Breast Cancer: Case Studies and Literature Review

“…Analysis of breast cancer in women suggests that overexpression of HER-2 is a potent predictor of response to treatment with monoclonal antibody trastuzumab alone or in combination with cytotoxic agents. This benefit is yet to be proved in man [79].…”