A retrospective analysis of the results of p(65) + Be neutrontherapy for the treatment of prostate adenocarcinoma at the cyclotron of Louvain-la-Neuve. Part I: survival and progression-free survival

Scalliet, Pierre; Remouchamps, Vincent; Lhoas, F.; Glabbeke, M. van; Curran, Desmond; Ledent, Tatiana; Wambersie, André; Richard, Françoise; Cangh, Paul Van

doi:10.1016/s1278-3218(01)00102-0

Cited by 9 publications

(2 citation statements)

References 28 publications

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“…36,37 A European mixed neutron/photon beam experience has been recently reported. 38 All patients were treated with a mixed photon/neutron irradiation in a two-tothree proportion, up to a total equivalent dose of 66 Gy (assuming a clinical RBE value of 2.8). Pre-and posttreatment PSA determinations were available in practically all cases.…”

Section: High-let Radiation: Neutronsmentioning

confidence: 99%

Particle therapy in prostate cancer: a review

Greco

2007

Prostate Cancer Prostatic Dis

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While dose escalation is proving important to achieve satisfactory long-term outcomes in prostate cancer, the optimal radiation modality to deliver the treatment is still a topic of debate. Charged particle beams can offer improved dose distributions to the target volume as compared to conventional 3D-conformal radiotherapy, with better sparing of surrounding healthy tissues. Exquisite dose distributions, with the fulfillment of dose-volume constraints to normal tissues, however, can also be achieved with photon-based intensity-modulated techniques. This review summarizes the literature on the use of particle therapy in prostate cancer and attempts to put in perspective its relative merits compared to current photon-based radiotherapy.

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Section: High-let Radiation: Neutronsmentioning

confidence: 99%

Particle therapy in prostate cancer: a review

Greco

2007

Prostate Cancer Prostatic Dis

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“…These particular types of lesions stem from the generation of so-called "locally multiply damaged sites" (LMDS) which are much less repairable than those induced by photons and eventually end up in cell death (Mustonen et al, 1999;Pouget and Mather, 2001). Thus, a successful approach for curing cancers refractory to conventional radiotherapy is provided by the irradiation of patients with high-LET particles such as neutrons (Scalliet et al, 2001) or heavy ions (Orecchia et al, 2004). The consequences of combining anticancer drugs with high-LET radiation, on cell survival remain little documented to date.…”

Section: Introductionmentioning

confidence: 99%