BackgroundDrip infusion cholangiography with computed tomography (DIC‐CT) is a major preoperative modality used for patients undergoing laparoscopic cholecystectomy (LC).MethodsThis study included 218 patients for whom preoperative DIC‐CT images were obtained prior to undergoing LC. The association between gallbladder (GB) opacification in DIC‐CT and the operative time was assessed.ResultsThe GB opacification on the DIC‐CT images was classified as follows: Grade 0, homogeneous opacification; Grade 1, heterogeneous opacification; Grade 2, only cystic duct can be identified; and Grade 3, no opacification. Images obtained for the 218 patients showed 41 (18.8%) with Grade 0, 91 (41.7%) with Grade 1, 54 (24.8%) with Grade 2, and 32 (14.7%) with Grade 3. The operative time and intraoperative blood loss were significantly longer and larger, respectively, in cases classified as Grade 2 or 3 (GB negative) compared with cases classified as Grade 0 or 1 (GB positive). We created an LC difficulty score based on the following variables that were significant independent predictors of increased operative time: GB negativity in DIC‐CT (P = .002, 2 points), GB wall thickness (P = .002, 2 points), body mass index (P = .015, 1 point), preoperative alkaline phosphatase value (P = .018, 1 point), and preoperative C‐reactive protein value (P = .04, 1 point). The LC difficulty score (Grade A, score 0‐2; Grade B, score 3‐5; and Grade C, score 6‐7) was significantly associated with a prolonged operative time.ConclusionDrip infusion cholangiography with computed tomography is useful for predicting the surgical difficulty of LC.