A retrospective cohort study of obstetric complications and birth outcomes in women with polycystic ovarian syndrome

Liu, Qiwei; Wang, Jingxue; Xu, Qian; Kong, Lin

doi:10.1080/01443615.2021.1931066

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…Further subgroup analysis found that PCOS women with pre-pregnancy insulin resistance were at an increased risk for GDM and macrosomia (all P < 0.05) ( 19 ). A retrospective cohort study including 1,357 pregnant women with PCOS and 6,940 without PCOS suggested that PCOS women had a higher rate of macrosomia (9.14% vs 6.64%, P = 0.008), and the difference was prominent among obese PCOS women with no significant difference (18.92% vs 8.00%, P = 0.15) ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study

et al. 2022

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ObjectiveThe objective of the study was to explore the effect of insulin resistance on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) from the first embryo transfer cycle.DesignThis was a single-center, retrospective, observational cohort study.PatientsIncluded in the study were women with PCOS for the first embryo transfer.Main Outcome MeasuresEarly miscarriage rate and macrosomia rate were the main outcome measures.ResultsWith increased HOMA-IR, the early miscarriage rate (7.14, 13.21, and 16.22%, respectively; P = 0.039), macrosomia rate (5.78, 11.79, and 17.58%, respectively; P = 0.026) and the incidence of gestational diabetes (GDM) (10.00, 14.50, and 25.67% respectively; P = 0.002) significantly increased, while the live birth rate markedly decreased (63.03, 55.27, and 47.88%, respectively; P = 0.004). No significant difference was found in clinical pregnancy rate, late miscarriage rate, low birthweight rate and baby gender ratio (all P >0.05). After adjusting for confounding factors, HOMA-IR was an independent risk factor of early miscarriage rate and macrosomia rate.ConclusionInsulin resistance is an independent risk factor for early miscarriage and macrosomia in PCOS patients during the first embryo transfer cycle. It is essential to give more attention before and after pregnancy for PCOS women with high HOMA-IR.

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Section: Discussionmentioning

confidence: 99%

Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study

et al. 2022

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“…The authors found an increased risk of GDM and HDP in individuals with PCOS compared with those without, which was further increased in those with obesity [44]. Individuals with PCOS requiring ART were not at an increased risk of these adverse pregnancy outcomes; therefore, IVF may be a well-tolerated and effective treatment of infertility associated with PCOS [44].…”

Section: Infertility Assisted Reproductive Technology and Polycystic ...mentioning

confidence: 97%

Section: Infertility Assisted Reproductive Technology and Polycystic ...mentioning

confidence: 99%

“…As many individuals with PCOS have infertility and require ART to achieve pregnancy, and ART is itself associated with adverse outcomes, several recent studies have evaluated adverse perinatal outcomes in pregnant individuals with PCOS treated with ART [35,43 ▪ ,44,45]. In a United States-based retrospective study ( N = 80 333), Stern et al included individuals with PCOS, determined by ICD-9/10 codes, undergoing ART ( N = 4061) compared with those not requiring ART with an adverse pregnancy outcome of GDM diagnosis, obtained from birth/death certificates and hospital records [43 ▪ ].…”

Section: Infertility Assisted Reproductive Technology and Polycystic ...mentioning

confidence: 99%

“…In a China-based retrospective cohort study, Liu et al [44] evaluated the risk of GDM (by IADPSG criteria) in individuals with PCOS ( N = 1357, diagnosed by Rotterdam criteria), compared with those without PCOS ( N = 6940). The authors found an increased risk of GDM and HDP in individuals with PCOS compared with those without, which was further increased in those with obesity [44]. Individuals with PCOS requiring ART were not at an increased risk of these adverse pregnancy outcomes; therefore, IVF may be a well-tolerated and effective treatment of infertility associated with PCOS [44].…”

Section: Infertility Assisted Reproductive Technology and Polycystic ...mentioning

confidence: 99%

See 2 more Smart Citations

Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome

Selen

Powe

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewThis review provides an update on gestational diabetes (GDM) and other adverse pregnancy outcomes in individuals with polycystic ovary syndrome (PCOS), one of the most common metabolic disorders and causes of infertility. Recent findingsRecent studies using Rotterdam diagnostic criteria for PCOS have supported prior literature suggesting that pregnant individuals with PCOS are at an increased risk of GDM. Risk factors for GDM in this population include overweight/obesity, insulin resistance, hyperandrogenism, amenorrhea, and history of miscarriage. It is possible that subtypes of PCOS (metabolic vs. lean/reproductive) pose differential risk. There are no current screening or treatment guidelines specifically for individuals with PCOS for GDM prevention. Although metformin has been studied for GDM prevention in PCOS, there has been no proven benefit. For infertility treatment, assisted reproductive technology and in-vitro fertilization do not appear to increase the risk of GDM in individuals with PCOS desiring pregnancy.

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Association Between Obesity in Women, Polycystic Ovary Syndrome and Adverse Obstetric Outcome

Ginod,

Dahan

2024

Obesity

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A retrospective cohort study of obstetric complications and birth outcomes in women with polycystic ovarian syndrome

Cited by 17 publications

References 35 publications

Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study

Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study

Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome

Association Between Obesity in Women, Polycystic Ovary Syndrome and Adverse Obstetric Outcome

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