A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil

Giovanetti, Marta; Pereira, Luiz Augusto; Adelino, Talita; Fonseca, Vagner; Xavier, Joilson; Fabri, Allison; Slavov, Svetoslav Nanev; Lemos, Poliana da Silva; Marques, William de Almeida; Kashima, Simone; Lourenço, José; Oliveira, Túlio de; Albuquerque, Carlos Frederico Campelo de; Freitas, Carla; Peterka, Cassio Roberto Leonel; Cunha, Rivaldo Venâncio da; Mendonça, Ana Flávia; Silva, Vinícius Lemes da; Alcântara, Luiz Carlos Júnior

doi:10.1128/spectrum.00155-22

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Viral genomic surveillance activities have been driven by the rapid development of DNA sequencing technology and bioinformatics tools for genomic data analysis 19 . Such tools have allowed the characterization of the genome and dispersal patterns of emerging and reemerging pathogens 6 , 9 , 20 . The use of such tools during the COVID-19 pandemic allowed, for example, the rapid identification of emerging mutations likely associated with increased transmissibility and immune escape 21 .…”

Section: Introductionmentioning

confidence: 99%

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

et al. 2023

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The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021–2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil.

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Section: Introductionmentioning

confidence: 99%

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

et al. 2023

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“…Of note, since 2016, several independent efforts have been made in genomic surveillance of ZIKV to cover most of the Brazilian territories over different time periods, such as the prominent ZiBRA project that produced more than 140 sequences (Zika in Brazil Real Time Analysis) [23,[27][28][29][30][31]. However, these great efforts were unable to rescue enough samples from this specific period due to logistic limitations in storing samples for long periods in Central Public Health Laboratories (LACEN).…”

Section: Resultsmentioning

confidence: 99%

Analyses of Early ZIKV Genomes are Consistent with Viral Spread from Northeast Brazil to The Americas

Moraes¹,

Portilho²,

Vrancken³

et al. 2023

Preprint

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The Americas, particularly Brazil, were greatly impacted by the widespread outbreak of Zika virus (ZIKV) in 2015 and 2016. Efforts were made to implement genomic surveillance of ZIKV as part of the public health responses. The accuracy of spatiotemporal reconstructions of the epidemic spread relies on the unbiased sampling of the transmission process. In the early stages of the outbreak, we recruited patients exhibiting clinical symptoms of arbovirus-like infection from Salvador and Campo Formoso, Bahia, in Northeast Brazil. Between May 2015 and June 2016, we identified 21 cases of acute ZIKV infection and subsequently recovered 14 near full-length sequences using the amplicon tiling multiplex approach with nanopore sequencing. We perform a time-calibrated discrete phylogeographic analysis to trace the spread and migration history of the ZIKV. Our phylogenetic analysis supports a consistent relationship between ZIKV migration from Northeast to Southeast Brazil and its subsequent dissemination beyond Brazil. Additionally, our analysis provides insights into the migration of ZIKV from Brazil to Haiti and the role Brazil played in the spread of ZIKV to other countries, such as Singapore, the USA and Dominican Republic. The data generated by this study enhances our understanding of ZIKV dynamics and supports the existing knowledge, which can aid in future surveillance efforts against the virus.

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“…Of note, since 2016, several independent efforts have been made in genomic surveillance of ZIKV to cover most of the Brazilian territories over different time periods, such as the prominent ZiBRA project (Zika in Brazil real-time analysis), which produced more than 140 sequences [ 24 , 54 , 55 , 56 , 57 , 58 ]. However, these great efforts were unable to rescue enough samples from this specific period due to logistical limitations in storing samples for long periods in Central Public Health Laboratories (LACEN).…”

Section: Resultsmentioning

confidence: 99%

Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas

Moraes

Portilho

Vrancken

et al. 2023

Viruses

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The Americas, particularly Brazil, were greatly impacted by the widespread Zika virus (ZIKV) outbreak in 2015 and 2016. Efforts were made to implement genomic surveillance of ZIKV as part of the public health responses. The accuracy of spatiotemporal reconstructions of the epidemic spread relies on the unbiased sampling of the transmission process. In the early stages of the outbreak, we recruited patients exhibiting clinical symptoms of arbovirus-like infection from Salvador and Campo Formoso, Bahia, in Northeast Brazil. Between May 2015 and June 2016, we identified 21 cases of acute ZIKV infection and subsequently recovered 14 near full-length sequences using the amplicon tiling multiplex approach with nanopore sequencing. We performed a time-calibrated discrete phylogeographic analysis to trace the spread and migration history of the ZIKV. Our phylogenetic analysis supports a consistent relationship between ZIKV migration from Northeast to Southeast Brazil and its subsequent dissemination beyond Brazil. Additionally, our analysis provides insights into the migration of ZIKV from Brazil to Haiti and the role Brazil played in the spread of ZIKV to other countries, such as Singapore, the USA, and the Dominican Republic. The data generated by this study enhances our understanding of ZIKV dynamics and supports the existing knowledge, which can aid in future surveillance efforts against the virus.

show abstract

A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil

Cited by 5 publications

References 23 publications

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

Analyses of Early ZIKV Genomes are Consistent with Viral Spread from Northeast Brazil to The Americas

Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas

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