A retrospective review of phyllodes tumors of the breast from a single institution

Abstract

BACKGROUND: Phyllodes tumors (PTs) are rare fibroepithelial breast tumors with diverse biological behavior. OBJECTIVE: This study aimed to analyze the characteristics, management, and outcome of phyllodes tumors. METHODS: Patients diagnosed with PTs in our institution from January 2013 to December 2017 were identified retrospectively by the ICD-10 code. Data were collected from medical records. The diagnosis of this tumor was based on histopathological results. Variables analyzed included age, tumor site, surgical option, axillary lymph nodes, chemotherapy and radiotherapy, metastases, disease-free survival (DFS), and overall survival (OS) rate. RESULTS: Sixty-nine cases of PTs were diagnosed during the period, of which 31 were benign, 38 were malignant, and 1 was a case of bilateral metachronous tumors. We did not find any borderline pathologic cases. The patient’s ages ranged from 20 to 71 years, with the highest number of cases (28) from the 40-49-year-old age group. The majority of patients (42) had PT on the right side. Simple mastectomy was the most performed treatment, with 53 such cases, including both benign and malignant. The axillary staging was carried out in 16 cases, of which none had nodal metastasis. Ten cases received chemotherapy, and 16 cases of malignant phyllodes received postoperative radiotherapy. We found 4 cases with distant metastases and 5 cases that developed local recurrence. The DFS rate reached 92.75%, and the overall 5-year survival rate was 84.21%. CONCLUSIONS: The incidence of PTs is highest in women in the 3rd and fourth decades of age. Simple mastectomy and wide excision are the treatments of choice, with a low recurrence rate in both benign and malignant PTs cases.

Phyllodes tumors: A retrospective study of 22 cases in the department of gyneco obstetrics 2 of the Hassan II university hospital

“…Phyllodes tumors (PTs) of the breast are uncommon fibro epithelial lesions that account for less than 0.5% of all breast tumors. [1][2][3] PTs are a rare diagnosis among breast tumors. In our study we found that PTs was representing 1,36 % of all breast tumors in our department during the period of the study.…”

“…Phyllodes tumors (PTs) of the breast are uncommon fibro epithelial lesions that account for less than 0.5% of all breast tumors. [1][2][3] The World Health Organization (WHO) has classified PTs histologically as benign, borderline, and malignant. 4 They are also graded by WHO based on their histopathological characteristics including stromal hypercellularity and atypia, cellular pleomorphism, mitotic activity, and margin appearance.…”

Resección de Tumor Phyllodes con Reconstrucción Inmediata de la Mama, Cirugía Oncoplástica: Reporte de Caso y Revisión de la Literatura

“…La radioterapia adyuvante puede ser beneficiosa para reducir la recurrencia local y, a veces, se considera para tumores filoides malignos de alto riesgo, que incluyen aquellos con un tamaño superior a 5 cm, crecimiento excesivo del estroma o más de 10 mitosis por campo de gran aumento. (2,12,15) En general, la radioterapia ha demostrado tener un efecto positivo en el control local de la enfermedad, aunque no se ha observado un alargamiento de la supervivencia. (3) En cuanto a la quimioterapia, se ha utilizado para la enfermedad recurrente y metastásica, aunque no se ha evidenciado un claro beneficio en la supervivencia.…”

Karakteristik Klinikopatologik Tumor Phyllodes Di Rsup Prof. Dr. I G.N.G. Ngoerah Periode 2018 – 2021

“…Penelitian tersebut memiliki rentang sampel penelitian dari usia 20-71 tahun dengan jumlah kasus terbanyak ada pada kelompok usia 40-49 tahun, yaitu sebanyak 28 pasien. 11 Studi histopatologi yang dilakukan di B.P Koirala Memorial Cancer Hospital menemukan hasil yang serupa pada klasifikasi kelompok usia sesuai dekade. Studi tersebut melaporkan bahwa jumlah kasus tumor payudara terbanyak ditemukan pada kelompok usia 40-49 tahun, yaitu sebanyak 31,2% dari total sampel.…”