A retrospective study of 30,959 implants: Risk factors associated with early and late implant loss

Lin, Guan; Ye, Shuhua; Liu, Fengjia; He, Fuming

doi:10.1111/jcpe.12898

Cited by 84 publications

(163 citation statements)

References 45 publications

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“…Due to the own traits of each case in clinical work of implantology, it was considered that a multifactorial etiology would lead to implant loss . As for participant variables, including gender and age, a higher failure risk was discovered in males than in females, which was in accordance with previous findings . In contrary, no significant difference of survival rates was detected between groups classified with age in our study, suggesting that age was not able to be a latent risk factor for implant loss.…”

Section: Discussionsupporting

confidence: 90%

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Analysis of implant loss risk factors especially in maxillary molar location: A retrospective study of 6977 implants in Chinese individuals

Zhou

Dong

Zhu

et al. 2018

Clin Implant Dent Rel Res

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Background The knowledge of the potential risk factors associated with implant loss is crucial for dental clinicians, but the opinions about the risk factors are still diverse and controversial. Purpose This retrospective study assessed the risk factors associated with implant loss, especially that in the maxillary molar location. Materials and Methods From January 2015 to March 2017, 4338 Chinese patients received 6977 implants at Nanjing Stomatological Hospital. Information on patient age, gender, bone grafting procedure, implant location, length and diameter, and the records of lost implants were obtained. The Kaplan‐Meier method and log‐rank test were used to conduct a survival function analysis. Chi‐square test and multivariate Cox regression analysis were used to identify risk factors related to implant loss. Results The cumulative survival rate (CSR) after 0‐32 months of observation period for all implants was 97.76%, and the CSR for maxillary molar implants was 97.00%. Maxillary molar implants showed a significantly lower CSR than the other implants (P < .05). Male sex, short implants (<10 mm) were considered as risk factors for implant loss. However, male sex and bone grafting procedure were regarded as risk factors for maxillary molar implant loss, which was slightly different from the result of all implants. Conclusions Male sex, short implants (<10 mm) and maxillary molar location were considered as potential risk factors for implant loss, whereas male sex and bone grafting procedure were significantly associated with implant loss in maxillary molar location.

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Section: Discussionsupporting

confidence: 90%

“…Different factors related to implant loss were explored, such as age, sex, implant length and diameter, expansion technique, implant location and so on . The conclusions were diverse in the analyses of different populations.…”

Section: Introductionmentioning

confidence: 99%

Analysis of implant loss risk factors especially in maxillary molar location: A retrospective study of 6977 implants in Chinese individuals

Zhou

Dong

Zhu

et al. 2018

Clin Implant Dent Rel Res

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“…The literature supports the evidence that SNPs play an important role in the transcription of these inflammatory mediators and may influence the osseointegration success, including single‐nucleotide polymorphism (SNPs) in MMPs …”

Section: Discussionmentioning

confidence: 57%

“…In this study, we observed a number of volunteers with reliable estimated statistical power, despite put out smokers—smoking is a strong risk factor for early implant failure . In addition, others risk factors with age, status periodontal, medically compromised, and position implant were exclude or matched.…”

Section: Discussionmentioning

confidence: 98%

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Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

Munhoz

Branco²,

Souza

et al. 2018

Clin Implant Dent Rel Res

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Background Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host response is influenced by genetic factors. Matrix metalloproteinases (MMPs) are enzymes that contribute to degradation and removal of collagen from extracellular matrix. Purpose This case‐control study aimed to investigate the haplotypic combination of MMP polymorphism (rs1144393, rs1799750, rs3025058, and rs11225395) and implant loss. Materials and Methods Two hundred nonsmokers subjects were matched by gender, age, implant number and position and divided in control group, 100 patients with one or more healthy implants, and test group, and 100 patients with one or more implant failures. Genomic DNA was extracted from saliva and genotypes were obtained by PCR‐RFLP. Results A significant association of rs1799750 (MMP‐1) and rs11225395 (MMP‐8) polymorphism on early implant loss was demonstrated (P ≤ 0.001). Global haplotype analysis indicated a significant difference between both groups (P < 0.0001). Haplotype T‐A‐GG‐5A‐C had a statistically significant risk effect, while haplotype C‐A‐G‐6A‐C andT‐G‐2G‐5A‐C had a protective effect in implant loss. Conclusions The results of this study showed that MMPs haplotype are a risk factor to early implant loss.

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Antimicrobial Potential of Strontium‐Functionalized Titanium Against Bacteria Associated With Peri‐Implantitis

Alshammari,

Neilands,

Jeppesen

et al. 2024

Clinical & Exp Dental Res

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ObjectivesTo explore the antimicrobial potential of strontium (Sr)‐functionalized wafers against multiple bacteria associated with per‐implant infections, in both mono‐ and multispecies biofilms.Materials and MethodsThe bactericidal and bacteriostatic effect of silicon wafers functionalized with a strontium titanium oxygen coating (Sr‐Ti‐O) or covered only with Ti (controls) against several bacteria, either grown as a mono‐species or multispecies biofilms, was assessed using a bacterial viability assay and a plate counting method. Mono‐species biofilms were assessed after 2 and 24 h, while the antimicrobial effect on multispecies biofilms was assessed at Days 1, 3, and 6. The impact of Sr functionalization on the total percentage of Porphyromonas gingivalis in the multispecies biofilm, using qPCR, and gingipain activity was also assessed.ResultsSr‐functionalized wafers, compared to controls, were associated with statistically significant less viable cells in both mono‐ and multispecies tests. The number of colony forming units (CFUs) within the biofilm was significantly less in Sr‐functionalized wafers, compared to control wafers, for Staphylococcus aureus at all time points of evaluation and for Escherichia coli at Day 1. Gingipain activity was less in Sr‐functionalized wafers, compared to control wafers, and the qPCR showed that P. gingivalis remained below detection levels at Sr‐functionalized wafers, while it consisted of 15% of the total biofilm on control wafers at Day 6.ConclusionSr functionalization displayed promising antimicrobial potential, possessing bactericidal and bacteriostatic ability against bacteria associated with peri‐implantitis grown either as mono‐species or mixed in a multispecies consortium with several common oral microorganisms.

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A retrospective study of 30,959 implants: Risk factors associated with early and late implant loss

Abstract: General factors such as male sex, elderly patients, mandibular anterior location, bone augmentation and short implants were associated with implant loss.

Cited by 84 publications

References 45 publications

Analysis of implant loss risk factors especially in maxillary molar location: A retrospective study of 6977 implants in Chinese individuals

Analysis of implant loss risk factors especially in maxillary molar location: A retrospective study of 6977 implants in Chinese individuals

Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

Antimicrobial Potential of Strontium‐Functionalized Titanium Against Bacteria Associated With Peri‐Implantitis

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