A retrospective study of skull base neoplasia in 42 dogs

Abstract

This study describes the prevalence and distribution of 42 cases of skull base neoplasia in dogs between 2000 and 2014. The average age of affected individuals was 9.5 years, and there was no sex or breed predisposition. The most common skull base neoplasms were meningioma (25 cases) and pituitary adenoma (9 cases). Less common tumors included craniopharyngioma (2 cases), nerve sheath tumor (2 cases), and 1 case each of pituitary carcinoma, meningeal oligodendrogliomatosis, presumed nasal or sinonasal carcinoma, and multilobular tumor of bone. All neoplasms caused some degree of compression of adjacent structures. The distribution of the tumors was greatest in the sellar region (n = 18), followed by the paranasal region (n = 12), caudal cranial fossa (n = 10), central cranial fossa (n = 1), and rostral cranial fossa (n = 1).

Transsphenoidal surgery: accuracy of an image‐guided neuronavigation system to approach the pituitary fossa (sella turcica)

“…Nonfunctional (hormonally silent) tumors typically cause clinical signs because of their large size and space‐occupying effects. Nonfunctional tumors may be pituitary in origin or of another tissue of origin such as craniopharyngioma, ependymoma, glioma, or meningioma or a metastatic tumor . The most common pituitary tumor in dogs is a tumor that causes pituitary‐dependent hyperadrenocorticism (PDH) .…”

“…Nonfunctional tumors may be pituitary in origin or of another tissue of origin such as craniopharyngioma, ependymoma, glioma, or meningioma or a metastatic tumor. 2 The most common pituitary tumor in dogs is a tumor that causes pituitary-dependent hyperadrenocorticism (PDH). 3 PDH is a common endocrine disorder in dogs, with approximately 100,000 new cases diagnosed per year in the United States.…”

“…7 Treatment options for pituitary and sellar tumors include medical management, 4,[8][9][10][11] radiation therapy, [12][13][14] and surgical management via transsphenoidal hypophysectomy (TS). [15][16][17][18] Medical management 10,11 and radiation treatment 13,14 may control some clinical signs but generally do not address 2 primary problems: (1) the mass causing compression of the brain resulting in neurologic deficits or (2) the hormonal dysregulation associated with the tumor, resulting in multiple clinical problems. In addition, medical management and radiation therapy do not provide a cure, whereas surgery potentially can; 57% of dogs treated surgically for PDH are disease free 5 years postoperatively.…”

Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

“…Em outro caso de G-III a localização foi na região olfatória. Em outros estudos, apesar de não ter sido discutido o assunto, foi observada uma baixa frequência de G-II e G-III na base do crânio em cães (Mandara et al 2010, Rissi 2015.…”

Use of MRI increases interobserver agreement on gross tumor volume for imaging‐diagnosed canine intracranial meningioma

“…14 However, MRI is inferior to CT in its ability to assess tumor-associated bone destruction or distortion, 13 which has been reported for canine meningioma. 15 A combination of CT and MRI is recommended for optimal target volume delineation for skull base meningiomas 13 and brain tumors 7 in human patients. Use of both CT and MRI to delineate GTV for meningiomas in canine patients is also reported [4][5][6]11,12 although CT imaging alone is also used.…”