A Retrospective Study on the Effect of Daeshiho-tang on the Lipid Profile in Patients with Uncontrolled Dyslipidemia by Statins

Noh, Ji-won; Jeong, Soo-min; Kim, Dong-Hyun; Yoo, Jeong-hwa; Ahn, Young‐Min; Ahn, Sung-Ho; Lee, Byung-cheol

doi:10.22246/jikm.2019.40.6.1026

Cited by 5 publications

(7 citation statements)

References 9 publications

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“…The overall effect of DSHT is metabolic regulation through lipid reduction [18]. In the current study, there was no statistically significant difference in body weight between the DSHT-treated mice and HFD-induced atherosclerosis models.…”

Section: Discussioncontrasting

confidence: 50%

“…Atherosclerosis is a progressive chronic inflammatory disease caused by maladaptive immune responses resulting from an imbalance in lipid metabolism and an accumulation of cholesterol-containing macrophages in the arterial wall. Recent evidence has suggested that DSHT has anti-hypertensive and anti-dyslipidemic properties that may contribute to the prevention of atherosclerosis [18]. In particular, the pharmacological effects of DSHT are derived from its main active ingredients [24], such as baicalin, saikosaponin A, sennoside B, and paeoniflorin, most of which have been clinically used because of their effects on lipid metabolism related to the risk of atherosclerosis [7].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, ongoing studies on the mechanisms of intrahepatic lipid synthesis inhibition and adipocyte differentiation might provide evidence that DSHT regulates lipid metabolism. Furthermore, clinical studies on DSHT have revealed its important effect in reducing LDL-C levels without causing relevant changes in the liver and kidney functions in dyslipidemia [18].…”

Section: Introductionmentioning

confidence: 99%

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Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

Song

Cho

Lee

et al. 2022

Life

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Dyslipidemia, the commonest cause of cardiovascular disease, leads to lipid deposits on the arterial wall, thereby aggravating atherosclerosis. DSHT (Daeshiho-tang) has long been used as an anti-dyslipidemia agent in oriental medicine. However, the anti-atherosclerotic effects of DSHT have not been fully investigated. Therefore, this study was designed to evaluate whether DSHT could exert beneficial anti-atherosclerotic effects. We fed apolipoprotein E-deficient (ApoE-/-) mice on a high-fat diet and treated them with atorvastatin (AT) or DSHT, or the combination of DSHT and AT for 12 weeks. To determine the role of DSHT, atherosclerotic lesions in the aorta, aortic root, and aortic arch; lipids and apolipoprotein levels in serum; and macrophage polarization markers in aorta tissues were examined. We show here that the DSHT decreased the atherosclerotic plaque ratio in the aortic arch, aorta, and aortic root. DSHT also regulated lipid levels by decreasing the ApoB level and increasing the ApoA1 level. Moreover, DSHT effectively regulated cholesterol metabolism by increasing the levels of PPARγ, ABCA1 and ABCG1, and the LDL receptor genes. We further found that DSHT promoted polarization to the M2 phenotype by increasing the levels of M2 macrophage (ARG1, CD163, and PPARγ) markers. Our data suggested that DSHT enhances the anti-atherosclerotic effect by regulating cholesterol metabolism through the activation of the PPARγ signaling pathway and by promoting anti-inflammatory M2 macrophage polarization.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

Song

Cho

Lee

et al. 2022

Life

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“…Many studies have been conducted to evaluate the anti-hyperlipidemic effects of single herbs and complex prescriptions in traditional Korean medicine, and some of them have been clinically tested to safely improve mild-to-moderate dyslipidemia [ 5 ]. Daeshiho-tang (DSHT) (Dai-saiko-to in Japan, Da-Chai-Hu-Tang in Chinese) is a complex prescription comprising eight herbs that are known to exert anti-hyperlipidemic [ [6] , [7] , [8] ], anti-atherosclerotic [ 9 ], anti-inflammatory [ 10 ], anti-hepatotoxic [ 11 ], anti-obesity [ 6 , 12 ], anti-hypertensive, and arterial contraction effects [ 13 ]. With respect to its anti-hyperlipidemic effects, DSHT reduces serum total cholesterol (TC), LDL-C, and triglyceride (TG).…”

Section: Introductionmentioning

confidence: 99%

“…However, most conducted studies are limited to in vitro or in vivo experiments, and clinical trials directed to identify the definite effects of DSHT on dyslipidemia are lacking. In our previous retrospective clinical study, DSHT when administered with statins could significantly lower TC and LDL-C levels in patients with uncontrolled dyslipidemia [ 7 ]. Thus, in this randomized, double-blinded pilot study, we assessed the lipid-lowering effect of DSHT extract and its safety profile in patients with dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

LDL cholesterol-lowering effect of Daeshiho-tang in patients with dyslipidemia: A pilot randomized, double-blind, placebo-controlled trial

Noh,

Lee

2023

Heliyon

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Network Analysis Using the Established Database (K-herb Network) on Herbal Medicines Used in Clinical Research on Heart Failure

Park¹,

Kim²,

Bae³

et al. 2023

J Int Korean Med

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Objectives: Heart failure is a chronic disease with increasing prevalence rates despite advancements in medical technology. Korean medicine utilizes herbal prescriptions to treat heart failure, but little is known about the specific herbal medicines comprising the network of herbal prescriptions for heart failure. This study proposes a novel methodology that can efficiently develop prescriptions and facilitate experimental research on heart failure by utilizing existing databases.Methods: Herbal medicine prescriptions for heart failure were identified through a PubMed search and compiled into a Google Sheet database. NetMiner 4 was used for network analysis, and the individual networks were classified according to the herbal medicine classification system to identify trends. K-HERB NETWORK was utilized to derive related prescriptions.Results: Network analysis of heart failure prescriptions and herbal medicines using NetMiner 4 produced 16 individual networks. Uhwangcheongsim-won (牛黃淸心元), Gamiondam-tang (加味溫膽湯), Bangpungtongseong-san (防風通聖散), and Bunsimgi-eum (分心氣飮) were identified as prescriptions with high similarity in the entire network. A total of 16 individual networks utilized K-HERB NETWORK to present prescriptions that were most similar to existing prescriptions. The results provide 1) an indication of existing prescriptions with potential for use to treat heart failure and 2) a basis for developing new prescriptions for heart failure treatment.Conclusion: The proposed methodology presents an efficient approach to developing new heart failure prescriptions and facilitating experimental research. This study highlights the potential of network pharmacology methodology and its possible applications in other diseases. Further studies on network pharmacology methodology are recommended.

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A Retrospective Study on the Effect of Daeshiho-tang on the Lipid Profile in Patients with Uncontrolled Dyslipidemia by Statins

Cited by 5 publications

References 9 publications

Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

LDL cholesterol-lowering effect of Daeshiho-tang in patients with dyslipidemia: A pilot randomized, double-blind, placebo-controlled trial

Network Analysis Using the Established Database (K-herb Network) on Herbal Medicines Used in Clinical Research on Heart Failure

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