A retrospective study on the outcomes of MPO-ANCA-associated vasculitis in dialysis-dependent patients

Hasegawa, Midori; Hattori, Kyoko; Sugiyama, Satoshi; Asada, Hiroaki; Yamashita, Hiroshi; Takahashi, Kazuo; Hayashi, Hiroki; Koide, Shigehisa; Sato, Waichi

doi:10.3109/14397595.2015.1045255

Cited by 8 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we first demonstrated that the CONUT score estimated at diagnosis could predict all-cause mortality in AAV patients during follow-up, but it could not be used to prognosticate either relapse or ESRD occurrence. To date, an increased rate of all-cause mortality in AAV patients has been reported to depend on several baseline factors determined at diagnosis, including MPO-ANCA positivity, late-onset AAV, and the CRP-to-serum albumin and the albumin-to-globulin ratios 892223. We re-evaluated their clinical correlation to the all-cause mortality rate in our study population.…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status Score is Associated with All-Cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

et al. 2019

View full text Add to dashboard Cite

PurposeThe controlling nutritional status (CONUT) score was developed to detect undernutrition in patients. Here, we investigated whether the CONUT score estimated at diagnosis could help predict poor outcomes [all-cause mortality, relapse, and end-stage renal disease (ESRD)] of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).Materials and MethodsWe retrospectively reviewed and collated data, including baseline characteristics, clinical manifestations (to calculate AAV-specific indices), and laboratory results, from 196 newly diagnosed AAV patients. Serum albumin, peripheral lymphocyte, and total cholesterol levels (at diagnosis) were used to calculate CONUT scores.ResultsIn total, 111 patients had high CONUT scores (≥3), which showed higher frequency of myeloperoxidase-ANCA and ANCA positivity, and demonstrated higher AAV-specific indices. The optimal cut-offs of CONUT score (at diagnosis) for predicting all-cause mortality and ESRD were ≥3.5 and ≥2.5, respectively. Patients with CONUT scores higher than the cut-off at diagnosis exhibited lower cumulative and ESRD-free survival rates compared to those with lower scores than the cut-off. In multivariable analyses, diabetes mellitus [hazard ratio (HR): 4.394], five-factor score (HR: 3.051), and CONUT score ≥3.5 (HR: 4.307) at diagnosis were independent predictors of all-cause mortality, while only serum creatinine (HR: 1.714) was an independent predictor of ESRD occurrence.ConclusionCONUT score at diagnosis is associated with all-cause mortality in AAV patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status Score is Associated with All-Cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The literature on the clinical course, survival rate, and relapse occurrence after the beginning of dialysis is scarce. Evidence suggests that vasculitis becomes quiescent after dialysis, and relapse rates seem to be much lower in these patients (reports range from 0.05 to 0.13 per person-year) [9][10][11][12]. Given the low rate of recurrence associated with the high risk of infection in ESKD patients, maintenance therapy is often unnecessary.…”

Section: Discussionmentioning

confidence: 99%

“…Despite being a common complication of the disease, there are not many reports regarding the clinical course, survival rate, or relapse rate after beginning dialysis. Evidence suggests that vasculitis becomes quiescent after dialysis, and relapse rates seem to be much lower in these patients (reports range from 0.05 to 0.13 per person-year) [9][10][11][12]. The authors present 3 cases of AAV relapse in patients already on dialysis.…”

Section: Introductionmentioning

confidence: 99%

ANCA Vasculitis Recurrence in Hemodialysis Patients: The Role of Rituximab

Oliveira¹,

Bernardo²,

Fonseca³

et al. 2021

Nephron

View full text Add to dashboard Cite

Antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) is characterized by systemic inflammation and is the most common cause of new-onset glomerulonephritis in adults older than 50 years. Renal disease secondary to AAV can lead to chronic kidney disease (CKD) requiring renal replacement therapy in approximately 20–25% of patients. Relapses are infrequent in the population on dialysis, and treatment guidelines do not specify these patients. Reports regarding the clinical course, survival, or relapse rate after beginning dialysis are scarce. The authors present 3 cases of CKD patients on hemodialysis who presented with AAV relapse, successfully treated with rituximab, and provide a literature review on relapse treatment.

show abstract

“…The risks of leukocytopenia and infection were lower in the RTX group than in the CY group in AAV patients with severe renal dysfunction ( 11 , 12 ). Pulmonary lesions, including AH, were shown to be the largest predictive factor for relapse and mortality in dialysis-dependent AAV patients ( 13 ). AH in AAV patients complicated with kidney failure like the present case is a critical issue, and its control is a problem directly related to the survival prognosis.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Alveolar Hemorrhaging in an Elderly and Renally Impaired Patient with Relapsing Anti-neutrophil Cytoplasmic Autoantibody-associated Vasculitis by Single Infusion of Rituximab

et al. 2018

View full text Add to dashboard Cite

Rituximab (RTX) has become a therapeutic option for inducing remission of anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV). However, the optimum dosage of RTX to induce remission of AAV and reduce adverse events, such as infection, remains unclear. We herein report an elderly and renally impaired patient with alveolar hemorrhaging due to refractory AAV who was successfully treated with single infusion of RTX. Single infusion of RTX may be a therapeutic option in refractory AAV patients who are vulnerable to infections.

show abstract

A retrospective study on the outcomes of MPO-ANCA-associated vasculitis in dialysis-dependent patients

Cited by 8 publications

References 24 publications

Controlling Nutritional Status Score is Associated with All-Cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Controlling Nutritional Status Score is Associated with All-Cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

ANCA Vasculitis Recurrence in Hemodialysis Patients: The Role of Rituximab

Improvement of Alveolar Hemorrhaging in an Elderly and Renally Impaired Patient with Relapsing Anti-neutrophil Cytoplasmic Autoantibody-associated Vasculitis by Single Infusion of Rituximab

Contact Info

Product

Resources

About