“…[26][27][28][29][30][31] Moreover, it is well known that rhodamine derivatives with a spirolactam structure are non-fluorescent; however, when rhodamine derivatives bind to metal ions or protons, ring-opened amides give rise to strong fluorescence emission. [32][33][34][35] On the basis of this interpretation, researchers have synthesized a series of rhodamine derivatives that can be used as fluorescence turn-on chemosensors for the detection metal ions, such as Hg 2+ , Cu 2+ , Sn 2+ , Cr 3+ , Sn 4+ and Pb 2+ . [36][37][38][39][40]26,41,42 Although, many rhodamine based sensors for Fe 3+ have been reported, 43,44 only few of them have been applied in biological systems for the detection of Fe 3+ .…”