2021
DOI: 10.52711/0974-360x.2021.00949
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A Review: Method Development Validation and Degradation Studies of some Anticancer Drugs

Abstract: This article reviews the various analytical methods reported so far in the literature for the determination of stability and impurity profile the lenalidomide and palbociclib anti cancer drugs in single or combination with other drugs in bulk, pharmaceutical dosage forms, biological fluids, stability indicating and impurity profiling methods. The analytical methods used for the estimation of lenalidomide and palbociclib anticancer drugs reviewed in this paper includes ultraviolet spectrophotometry,high perform… Show more

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Cited by 5 publications
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“…In this calculation, σ represents the standard deviation of response and S is the slope of the calibration curve. [16][17][18] Studies on forced degradation Analysis of all forced degradation trials was done at the concentration level of 10 µg/mL. The drug solution was treated with 1-mL of 0.1N HCl for acid degradation, 1-mL of 1N NaOH for alkaline degradation, and 1-mL of 10% H 2 O 2 for oxidative degradation.…”
Section: Limit Of Detection and Limit Of Quantitationmentioning
confidence: 99%
“…In this calculation, σ represents the standard deviation of response and S is the slope of the calibration curve. [16][17][18] Studies on forced degradation Analysis of all forced degradation trials was done at the concentration level of 10 µg/mL. The drug solution was treated with 1-mL of 0.1N HCl for acid degradation, 1-mL of 1N NaOH for alkaline degradation, and 1-mL of 10% H 2 O 2 for oxidative degradation.…”
Section: Limit Of Detection and Limit Of Quantitationmentioning
confidence: 99%