A review of advanced nanoformulations in phototherapy for cancer therapeutics

Hak, Arshadul; Shinde, Vinod Ravasaheb; Rengan, Aravind Kumar

doi:10.1016/j.pdpdt.2021.102205

Cited by 54 publications

(44 citation statements)

References 72 publications

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“…In vivo results suggest that it reaches efficacy in prolonging the life of mice with leukemia compared to free cisplatin. However in clinical trials, less than 6% of patients exhibited a response to this formulation and, additionally, there have been reports suggesting limited stability of the combination [ 81 ].…”

Section: Nanocarriers Of Platinum and Palladium Complexesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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Section: Nanocarriers Of Platinum and Palladium Complexesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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“…This technique could have considerable advantages, especially studying promising treatments such as phototherapy in cancer. 28,29 Pharmacological intervention on specific molecular factors to stop tumour progression has problems in terms of personalization of the administered doses and side effects. Then, therapeutic Basis of the model is to detect plasmatic membrane integrity and mitochondrial function simultaneously using propidium iodide and rhodamine 123, generating 3 possible probabilities: 1.…”

Section: Discussionmentioning

confidence: 99%

“…In this way, the association of phototherapy and drugs is promissory, by understanding the right way to induce the expression of light-sensitive channels in tumours, or by activation of drugs, including the use of light-activated nanoparticles. 28,30 The optogenetic platform, presented in the current study, can be used in studies requiring specific cell culture conditions to be maintained for long time periods and has the advantage of being used in the cell incubator after sterilization by exposure to UV light and 70% ethanol, different to other available platforms. It generates enough light intensity for the stimulation of ChR2 channels.…”

Section: Discussionmentioning

confidence: 99%

Optogenetic control of cancer cell survival in ChR2‐transfected HeLa cells

Córdova

Lozano

Rodríguez

et al. 2021

Int J Experimental Path

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Optogenetics is a molecular biological technique involving transfection of cells with photosensitive proteins and the subsequent study of their biological effects. The aim of this study was to evaluate the effect of blue light on the survival of HeLa cells, transfected with channelrhodopsin‐2 (ChR2). HeLa wild‐type cells were transfected with a plasmid that contained the gene for ChR2. Transfection and channel function were evaluated by real‐time polymerase chain reaction (RT‐PCR), fluorescence imaging using green fluorescent protein (GFP) and flow cytometry for intracellular calcium changes using a Fura Red probe. We developed a platform for optogenetic stimulation for use within the cell culture incubator. Different stimulation procedures using blue light (467 nm) were applied for up to 24 h. Cell survival was determined by flow cytometry using propidium iodide and rhodamine probes. Change in cell survival showed a statistically significant (p < 0.05) inverse association with the frequency and time of application of the light stimulus. This change seemed to be associated with the ChR2 cis‐trans‐isomerization cycle. Cell death was associated with high concentrations of calcium in the cytoplasm and stimulation intervals less than the period of isomerization. It is possible to transfect HeLa cells with ChR2 and control their survival under blue light stimulation. We suggest that this practice should be considered in the future development of optogenetic systems in biological or biomedical research.

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“…Phototherapy consists in the irradiation (generally with near‐infrared laser) of a molecule capable of absorbing light energy and destroying the tumor by catalyzing the synthesis of reactive oxygen species (ROS) (photodynamic therapy, PDT) or by generating heat (photothermal therapy, PTT). [ 28 ] Unfortunately, the application of PDT is restricted by the physicochemical properties of photosensitizers, that often result slightly soluble in water, and their self‐destruction under laser irradiation. [ 29 ] Besides, photosensitizers are not able to specifically target tumor tissues, an can be observed also in normal tissues.…”

Section: Hyaluronic‐acid‐based Devicesmentioning

confidence: 99%

Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy

Sala

Fabozzi

Gennaro

et al. 2021

Macromolecular Bioscience

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Cancer is the main cause of fatality all over the world with a considerable growth rate. Many biologically active nanoplatforms are exploited for tumor treatment. Of nanodevices, hyaluronic acid (HA)‐based systems have shown to be promising candidates for cancer therapy due to their high biocompatibility and cell internalization. Herein, surface functionalization of different nanoparticles (NPs), e.g., organic‐ and inorganic‐based NPs, is highlighted. Subsequently, HA‐based nanostructures and their applications in cancer therapy are presented.

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A review of advanced nanoformulations in phototherapy for cancer therapeutics

Cited by 54 publications

References 72 publications

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Optogenetic control of cancer cell survival in ChR2‐transfected HeLa cells

Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy

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