A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules

Choonara, Bibi F.; Choonara, Yahya E.; Kumar, Pradeep; Bijukumar, Divya; Toit, Lisa C. du; Pillay, Viness

doi:10.1016/j.biotechadv.2014.07.006

Cited by 266 publications

(144 citation statements)

References 125 publications

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“…Strategies to enhance oral delivery of peptides typically include use of permeation enhancers (PEs), enzyme inhibitors, multi-particulate systems, nanotechnology, targeted particulates, colonic delivery approaches, as well as peptide modification [3,16,84]. The most promising strategies applied to oral delivery of peptides by companies at different clinical stages are discussed here.…”

Section: Brief Assessment Of Selected Oral Peptide Strategies In Precmentioning

confidence: 99%

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

Aguirre

Teijeiro‐Osorio

Rosa

et al. 2016

Advanced Drug Delivery Reviews

262

151

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Publication informationAdvanced Drug Delivery Reviews, 106 (Part B):Publisher Elsevier Item record/more information http://hdl.handle.net/10197/7801 Publisher's statementThis is the author's version of a work that was accepted for publication in Advanced Drug Delivery Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advanced Drug Delivery Reviews (106, Part B, (2016)

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Section: Brief Assessment Of Selected Oral Peptide Strategies In Precmentioning

confidence: 99%

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

Aguirre

Teijeiro‐Osorio

Rosa

et al. 2016

Advanced Drug Delivery Reviews

262

151

View full text Add to dashboard Cite

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“…However, using polymer micelles for oral drug delivery of macromolecular drugs (such as peptides, proteins, nucleic acids and sugars) is still fairly new and presents a major challenge because the human gastrointestinal tract resists the absorption of peptides, proteins, nucleic acids and other large molecules unless they are broken down into smaller molecules. [129][130][131] To optimize the oral delivery of biological macromolecules, various approaches have been pursued, including protective coatings [132][133][134] to protect the peptides during transport through the highly acidic environment in the stomach, targeted delivery, permeation enhancers, protease inhibitors, 135 and bioadhesive microparticles. [136][137][138] Nagasaki and coworkers designed reactive oxygen species (ROS) responsive nanoparticles (RNPO) for oral chemotherapy.…”

Section: Oral Delivery Routesmentioning

confidence: 99%

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

et al. 2016

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“…Some of them have progressed to the clinical trial stage, such as Multi Matrix MMX Õ technology and CODES Ô technology (Choonara et al, 2014). MMX Õ technology was produced for the oral delivery of active pharmaceutical agents (e.g.…”

Section: Proteins and Peptide Therapeuticsmentioning

confidence: 99%

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

et al. 2017

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PR China AbstractOral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal epithelium in the gastrointestinal (GI) tract. pH-Responsive carriers offer excellent potential as oral therapeutic systems due to enhancing the stability of drug delivery in stomach and achieving controlled release in intestines. This review provides a wide perspective on current status of pH-responsive oral drug delivery systems prepared mainly with organic polymers or inorganic materials, including the strategies used to overcome GI barriers, the challenges in their development and future prospects, with focus on technology trends to improve the bioavailability of orally delivered drugs, the mechanisms of drug release from pH-responsive oral formulations, and their application for drug delivery, such as protein and peptide therapeutics, vaccination, inflammatory bowel disease (IBD) and bacterial infections.

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A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules

Cited by 266 publications

References 125 publications

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

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