A Review of Anti-inflammatory Terpenoids from the Incense Gum Resins Frankincense and Myrrh

Morikawa, Toshio; Matsuda, Hisashi; Yoshikawa, Masayuki

doi:10.5650/jos.ess16149

Cited by 42 publications

(26 citation statements)

References 58 publications

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“…The oleo-gum resin from Boswellia serrata (Burseraceae), or Indian frankincense, contains chemical constituents such as alkaloids, terpenoids, tannins, phenols, saponins and triterpenes. These compounds have been largely used in traditional Indian medicine for their many beneficial properties such as anti-inflammatory and antiarthritic effects [42], but their efficacy in mouse models of chemically induced colitis is debated [43]. Specific evidence of the frankincense protection properties on membrane integrity was found by Catanzaro et al [16] on Caco-2 human intestinal cells, subjected to inflammation mediators (INF-γ or TNF-α) or to hydrogen peroxide (source of free radicals).…”

Section: Discussionmentioning

confidence: 99%

Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin

Parisio,

Lucarini,

Micheli

et al. 2019

Nutrients

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Abdominal pain is a frequent symptom of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBDs). Although the knowledge of these pathologies is progressing, new therapeutic strategies continue to be investigated. In the present study, the effect of a system of molecules of natural origin (a medical device according to EU Directive 93/42/EC, engineered starting from Boswellia serrata resins, Aloe vera polysaccharides and Matricaria chamomilla and Melissa officinalis polyphenols) was evaluated against the intestinal damage and visceral pain development in DNBS-induced colitis model in rats. The system (250 and 500 mg kg−1) was orally administered once daily, starting three days before the injection of 2,4-dinitrobenzenesulfonic acid (DNBS) and for 14 days thereafter. The viscero-motor response (VMR) to colon-rectal balloon distension (CRD) was used as measure of visceral sensitivity. The product significantly reduced the VMR of DNBS-treated animals. Its effect on pain threshold was better than dexamethasone and mesalazine, and not lower than amitriptyline and otilonium bromide. At microscopic and macroscopic level, the tested system was more effective in protecting the intestinal mucosa than dexamethasone and mesalazine, promoting the healing of tissue lesions. Therefore, we suggest that the described system of molecules of natural origin may represent a therapeutic option to manage painful bowel diseases.

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Section: Discussionmentioning

confidence: 99%

Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin

Parisio,

Lucarini,

Micheli

et al. 2019

Nutrients

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“…The resin has attracted pharmacological interest for its therapeutic potential against arthritis, asthma, colitis, Crohn's disease, and cancer. It is considered a promising alternative to the non-steroidal anti-inflammatory drug ( Moussaieff and Mechoulam, 2009;Morikawa et al,2017 ;Bertocchi et al 2018).…”

Section: Boswellic Acidmentioning

confidence: 99%

Role of Boswellic Acid in the Treatment of Peptic Ulcer Disease

Sherif¹

2019

Al-Azhar Journal of Pharmaceutical Sciences

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A peptic ulcer is a chronic disease. Its main features are the incompetent defense of the mucosal and the existence of the gastric juice. The two most important factors that disrupt the balance between the acid and the mucus are the Helicobacter pylori infection (H. pylori) and Non-steroidal anti-inflammatory drugs (NSAIDs). The known treatments like proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists have demonstrated adverse effects and various drug interactions. So the desired approach nowadays is alternative therapies and the usage of herbal products. Boswellic acids provide a potential alternative to the treatment of non-steroidal anti-inflammatory drugs induced peptic ulcer.

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“…Monoterpenoids are formed of two isoprene units, whereas sesquiterpenoids consist of three units. Both mentioned groups are commonly denoted as low-molecular-weight terpenoids, which are one of the most varied groups of plant products that include more than 25,000 compounds [118]. The phenylpropanoid group of terpenoids is less common and is based on a nine-carbon skeleton, whereas their synthesis pathway differs from the other terpenoids [119].…”

Section: Resinsmentioning

confidence: 99%

“…Since they exhibit various biological activities, they are found in several herbal remedies [121]. Of particular importance in relation to wound healing are their antibacterial and antiviral effects, whereas they possess also other activities like the antineoplastic activity, as well as stimulation gastrointestinal tract [118]. They are not toxic unless they are concentrated as volatile oils [122].…”

Section: Resinsmentioning

confidence: 99%

Plant-Derived Medicines with Potential Use in Wound Treatment

Maver¹,

Kurečič²,

Smrke³

et al. 2019

Herbal Medicine

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The skin is among the largest and one of the most important organs in the human body. It represents the first line of defence of the body; provides protection from mechanical impacts of the environment, limits the influence of variations in the temperature, prevents entrance of chemicals and microorganisms and restricts radiation effect. Skin damage affects all skin functions; therefore, wounds can compromise patient's well-being, self-image, working capacity and independence. Due to all mentioned, a good wound management is necessary not only for the individual but also for the community. Herbal medicines have been used to accelerate wound healing since ancient times. Recently, scientists have been able to employ scientific methods to prove efficacy of many of these herbs and to get a better understanding of mechanisms of their actions. The popularity of herbal medicines may be explained by the perception that herbs cause minimal adverse effects. Preparations from traditional medicinal plants in wound management involve disinfection, debridement and the provision of suitable environment for natural healing process. In this chapter, the field of wound healing is briefly introduced. Further, the crucial information regarding plants, which are effectively used as wound healing agents in traditional medicine are gathered.

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A Review of Anti-inflammatory Terpenoids from the Incense Gum Resins Frankincense and Myrrh

Cited by 42 publications

References 58 publications

Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin

Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin

Role of Boswellic Acid in the Treatment of Peptic Ulcer Disease

Plant-Derived Medicines with Potential Use in Wound Treatment

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