A review of antigen diversity causing lung disease among pigeon breeders

McSharry, Charles; Anderson, Kenneth E.; Boyd, G.

doi:10.1046/j.1365-2222.2000.00810.x

Cited by 43 publications

(24 citation statements)

References 72 publications

(74 reference statements)

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“…However, a few samples without precipitating antibodies had rather high IgG values, and some samples with precipitating antibodies had low IgG values. Similar observations have been reported (11,12,(27)(28)(29) and may be partly explained by differences in assay detection limit and quality and composition of the antigen extract. Indeed, pigeon serum antigen was used in the precipitation assay, whereas the antigen coupled to the ImmunoCAP contained proteins from serum, feathers, and droppings.…”

Section: Influence Of Antigen Contact On Antibody Productionsupporting

confidence: 87%

Quantification of IgG Antibodies to Aspergillus fumigatus and Pigeon Antigens by ImmunoCAP Technology: An Alternative to the Precipitation Technique?

2006

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Section: Influence Of Antigen Contact On Antibody Productionsupporting

confidence: 87%

Quantification of IgG Antibodies to Aspergillus fumigatus and Pigeon Antigens by ImmunoCAP Technology: An Alternative to the Precipitation Technique?

2006

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“…The results of previous studies showed that the IgG antibody response, perhaps involving different subclasses, is a very good marker for AA. It has been demonstrated that serum, droppings and feathers of birds contain antigens such as bird IgA immunoglobulins and mucin [10, 18, 19]. Taken the different antigen responses to the various antigen sources into account, it seems reasonable to use antigen mixes for the determination of raised IgG antibody levels.…”

Section: Discussionmentioning

confidence: 99%

“…IgG antibodies directed against numerous bird products, such as serum, droppings and feathers, may play an important role in AA [10]. Owing to the difficulties in obtaining antigenic extracts of these materials, studies aimed at quantifying antibodies to different antigenic sources are very limited.…”

Section: Introductionmentioning

confidence: 99%

Qualitative and Quantitative Evaluation of Bird-Specific IgG Antibodies

Lopata

Schinkel²,

Potter³

et al. 2004

Int Arch Allergy Immunol

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Background: Exposure to organic dust produced by birds often gives rise to an immune response, e.g. IgG antibodies, but intense exposure can lead to high concentrations of IgG antibodies and the development of allergic alveolitis, often known as ‘bird fancier’s lung’. The aim of this study was to establish the distribution of bird-specific IgG antibodies in exposed and nonexposed individuals and compare a nonquantitative and quantitative method in evaluating raised levels of IgG antibodies. Methods: Sera were collected in Sweden and South Africa and levels of IgG antibodies specific to pigeon, budgerigar and parrot antigens were quantified using the UniCAP system. Results were compared to the precipitation in gel assay. The IgG antibody values of symptomatic patients without precipitating antibodies (non-PP group; n = 51) and patients with precipitating antibodies (PP group; n = 34) were analyzed and compared to nonexposed asymptomatic blood donors (BD group; n = 73) and environmentally exposed pigeon breeders (n = 11). Results: The IgG antibody response of the analyzed groups in Sweden and South Africa did not vary significantly from each other. IgG antibody responses were the strongest to pigeon antigens with clear increased IgG antibody levels in the PP group [geometric mean (GM) 603 mg/l] compared to the non-PP (GM 6.9 mg/l) and BD group (GM 5.0 mg/l). Threshold values, calculated as the GM value from the BD group plus 3 standard deviations (99% confidence interval), were 9.8, 10.8 and 10.0 mg/l for pigeons, budgerigars and parrots, respectively. Comparison of the two methods resulted in a good concordance with a level of agreement of 94.1% (kappa statistic = 0.83). Conclusions: The UniCAP system for the detection of bird-specific IgG antibodies is a highly reproducible, generally available, quantitative method for routine diagnostic testing and monitoring of exposed subjects with a very high level of agreement to the precipitating gel assay.

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“…The clinical manifestations, functional respiratory tests, imaging studies, and histopathological findings are consistent with a predominant interstitial lung involvement (2,3). A diversity of immunological abnormalities may also distinguish the disease, and they have been useful to define the diagnosis and/or approach its pathogenesis (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

“…Pigeon fancier's disease has been recognized as one of the most common HP subsets, and is caused by the inhalation of organic dusts derived mainly from feathers and/or avian droppings (1). The clinical manifestations, functional respiratory tests, imaging studies, and histopathological findings are consistent with a predominant interstitial lung involvement (2,3).…”

Section: Introductionmentioning

confidence: 99%

IgM, IgG, and IgA rheumatoid factors in pigeon hypersensitivity pneumonitis

Araiza¹,

León

Retana

et al. 2007

Clinical Laboratory Analysis

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The association of rheumatoid factor (RF) and lung disease in several immunologically mediated conditions has suggested that it may be physiopathologically relevant. Since previous reports in hypersensitivity pneumonitis (HP) have dealt mainly with the immunoglobulin M (IgM) RF measurement, we studied such antibody activity in other immunoglobulins, to determine the IgG and IgA RF levels in pigeon-HP, and in asymptomatic breeders (AB) and rheumatoid arthritis (RA) as controls. RFs were measured in 35 HP patients, 41 AB, 31 RA controls, and 55 healthy donors by enzyme-linked immunosorbent assay (ELISA) using human or rabbit immunoglobulin G (IgG), anti-IgM, F(ab')2 of IgG, and IgA F(ab')2 conjugates. An affinity chromatography, fragment crystallizable (Fc) preparations of IgG, pepsin digestion, and Western blots were used to confirm RF specificity. We also evaluated anti-avian antibodies (AA) and cross-reacting antibodies. The HP group revealed positive IgM (51.4%), IgG (31.4%), and immunoglobulin A (IgA) (34.2%) RF tests, and these antibody values exceeded the AB reference levels (P<0.02). HP and RA showed a similar frequency and distribution of RFs. Possible immunoassay interferences were excluded. As in other immunologically mediated diseases, IgG and IgA RFs may play a pathogenic role in HP, amplifying the inflammatory reaction, immune-complex formation, and complement activation. IgM-RF producing cells that have been implicated in the presentation of self and foreign antigens, and T-cell activation might induce the isotype switching of RFs.

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A review of antigen diversity causing lung disease among pigeon breeders

Cited by 43 publications

References 72 publications

Quantification of IgG Antibodies to Aspergillus fumigatus and Pigeon Antigens by ImmunoCAP Technology: An Alternative to the Precipitation Technique?

Quantification of IgG Antibodies to Aspergillus fumigatus and Pigeon Antigens by ImmunoCAP Technology: An Alternative to the Precipitation Technique?

Qualitative and Quantitative Evaluation of Bird-Specific IgG Antibodies

IgM, IgG, and IgA rheumatoid factors in pigeon hypersensitivity pneumonitis

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