Quantification of IgG Antibodies to Aspergillus fumigatus and Pigeon Antigens by ImmunoCAP Technology: An Alternative to the Precipitation Technique?

Hoeyveld, Ernestina Van; Dupont, Lieven; Bossuyt, Xavier

doi:10.1373/clinchem.2006.067546

Cited by 62 publications

(38 citation statements)

References 27 publications

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“…The results of the immediate-type and the late-type responses were judged to be positive in a case of the longer axis of the flare beyond 10 mm at 15 minutes and at 8 hour after the injection, respectively. The Phadia (previously Pharmacia) CAP system was used to quantify specific IgG and IgE levels (Phadia Ltd, Uppsala, Sweden) [18]. A positive test was taken as a measurement > 2.00 (mgA / L) and > 0.35 (UA/mL), respectively.…”

Section: Intradermal Skin Test and Serological Testmentioning

confidence: 99%

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Ogawa

Fujimura

Takeuchi

et al. 2011

Pulmonary Pharmacology & Therapeutics

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Abstract(Background) There is a close link between fungal sensitization and asthma severity.Though Schizophillum commune (S. commune, called"suehirotake"in Japanese), one of the basidiomycetous (BM) fungi, is a fungus that can cause allergic bronchopulmonary mycosis (ABPM) and allergic fungal sinusitis (AFS), whether the fungus causes or sensitizes the asthma is unclear. (Methods) The bronchial provocation test using S. commune may be a causative fungal antigen of bronchial asthma.

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Section: Intradermal Skin Test and Serological Testmentioning

confidence: 99%

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Ogawa

Fujimura

Takeuchi

et al. 2011

Pulmonary Pharmacology & Therapeutics

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“…IgG antibodies were measured using complement fixation test in most cases. Specific IgE for Aspergillus was measured using a radioallergosorbent assay and that for Schizophyllum commune was measured according to the Phadia CAP system (Phadia Ltd., Uppsala, Sweden) (8). The study protocol was approved by the Ethics Committee of Saitama Cardiovascular and Respiratory Center (No.…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics of Biopsy-proven Allergic Bronchopulmonary Mycosis: Variety in Causative Fungi and Laboratory Findings

Ishiguro¹,

Takayanagi²,

Kagiyama³

et al. 2014

Intern. Med.

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Objective The diagnosis of allergic bronchopulmonary mycosis (ABPM) has traditionally relied widely on Rosenberg's criteria, which emphasize immunologic responses while overlooking the investigation of mucous plugs as a primary criterion. Therefore, the characteristics of biopsy-proven ABPM require further elucidation. The aim of this study was to analyze the clinical characteristics of biopsy-proven ABPM and address whether full compliance with clinical criteria, such as the presence of asthma, and certain laboratory findings is necessary to establish a diagnosis of ABPM. Methods We retrospectively analyzed 17 patients with biopsy-proven ABPM focusing on causative fungi and laboratory findings. Results Causative fungi included Aspergillus sp. in seven patients, Schizophyllum commune in four patients, Penicillium sp. in two patients and unknown in five patients. Bronchial asthma was observed in 10 patients, eosinophilia was observed in 10 patients and an increased serum immunoglobulin (Ig) E level was observed in 14 of the 17 patients. IgG for Aspergillus sp. was positive in six of the seven patients with ABPM due to Aspergillus and turned positive in the remaining patient during follow-up. Technological limitations prevented the measurement of specific IgE for S. commune and IgG for S. commune and Penicillium sp. in most patients. Computed tomography revealed central bronchiectasis, pulmonary infiltration and mucous plugs in all patients. Conclusion Causative fungi other than Aspergillus sp. are not uncommon, and immunological tests for other fungi should be popularized. Asthma and characteristic laboratory findings, such as peripheral blood eosinophilia, increased serum IgE and precipitating antibodies, may not always be required to diagnose ABPM. The importance of typical pathologic findings of mucous plugs for diagnosing ABPM requires reevaluation. Further studies are needed to establish more elaborate diagnostic criteria for ABPM.

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“…Aliquots of serum were stored at −20°C. Specific IgE and IgG antibodies to A. fumigatus were analysed using an Immuno Cap system(Thermo Fisher/Phadia, Uppsala, Sweden) [27].…”

Section: Flow Cytometrymentioning

confidence: 99%

CXCR4⁺granulocytes reflect fungal cystic fibrosis lung disease

et al. 2015

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Quantification of IgG Antibodies to Aspergillus fumigatus and Pigeon Antigens by ImmunoCAP Technology: An Alternative to the Precipitation Technique?

Cited by 62 publications

References 27 publications

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Clinical Characteristics of Biopsy-proven Allergic Bronchopulmonary Mycosis: Variety in Causative Fungi and Laboratory Findings

CXCR4⁺granulocytes reflect fungal cystic fibrosis lung disease

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Quantification of IgG Antibodies to Aspergillus fumigatus and Pigeon Antigens by ImmunoCAP Technology: An Alternative to the Precipitation Technique?

Cited by 62 publications

References 27 publications

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Clinical Characteristics of Biopsy-proven Allergic Bronchopulmonary Mycosis: Variety in Causative Fungi and Laboratory Findings

CXCR4+granulocytes reflect fungal cystic fibrosis lung disease

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CXCR4⁺granulocytes reflect fungal cystic fibrosis lung disease