2016
DOI: 10.1002/phar.1764
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A Review of Antiviral and Antifungal Use and Safety during Pregnancy

Abstract: Antiviral and antifungal use in pregnancy presents challenges because of the paucity of clinical and safety data for many agents in these classes. If untreated, viral and fungal infections can have deleterious effects on both maternal and fetal health. Understanding the use and risks of these medications in pregnancy is vital to provide appropriate care. This article reviews the current literature for the use of antiviral and antifungals, the pharmacokinetics of these agents, and their safety in pregnancy.

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Cited by 16 publications
(16 citation statements)
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“…However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43,55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis.…”
Section: Discussion On Antifungal Treatment Options and Challenges Fomentioning
confidence: 99%
“…However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy. The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43,55]. Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis.…”
Section: Discussion On Antifungal Treatment Options and Challenges Fomentioning
confidence: 99%
“…In animal models, each crosses the placenta, with teratogenicity at the recommended human dose. 3 Table 1 summarizes data from animal studies. All echinocandins have been found in breast milk of lactating rats.…”
Section: Discussionmentioning
confidence: 99%
“…Egy másik ismert azol származékot, a Ketokonazolt C (ADEC B3) kategóriába sorolták. Annak ellenére, hogy a placentán csak csekély mennyiségben jut át, negatívan befolyásolja a magzat szexuális fejlődését, ezért alkalmazása kontraindikált az állapotos időszak összes trimestere alatt [7].…”
Section: Gombaölő Szerekunclassified
“…Az orofacialis régióban kialakuló gingivostomatitis herpetica lokális kezelése Aciclovirral semmilyen károsodást nem okoz a magzatban, ezért az FDA is B (ADEC B3) kategóriába sorolta. A vertikális fertőződés veszélye csekély, kisebb mint 1%, azonban ha bekövetkezik, a gyermek vakságát, mentális retardáltságát vagy akár a magzat intrauterin halálát is okozhatja [7]. A szülés közbeni átfertőződés elkerülése érdekében a 36. héttől pro fi lak ti kus per os aciclovir szedését ajánlják.…”
Section: Vírusellenes Szerekunclassified