Background The aetiology of oral cancer is multifactorial, as various risk factors (genetics, socioeconomic and lifestyle factors) contribute to its development. Data in the literature suggest that people with periodontal disease have an increased risk of developing oral cancer, and the severity of periodontitis correlates with the appearance of oral squamous cell carcinoma. The aim of this study was to revise the non-genetic risk factors that may influence the development of OC, while focusing on the dental and periodontal status and OH. Methods Two hundred patients (hundred diagnosed with oral cancer and hundred without oral cancer) were enrolled in our case–control study, to evaluate the association between oral cancer and the presence and severity of periodontitis, while examining several risk factors that might be responsible for oral cancer formation. A questionnaire customised for oral cancer patients was used to obtain the socioeconomic and lifestyle risk factors that may influence the development of oral squamous cell carcinoma. The dental and periodontal status along with the level of oral hygiene was recorded quantitatively. The chi-square and Mann–Whitney tests and logistic regression were used for the statistical analysis. Results By considering both the case and the control groups, a significant correlation was found between the incidence of oral cancer and some socioeconomic factors and lifestyle habits, such as the sex, age, education and alcohol consumption of an individual. The mean value of the Silness-Löe plaque index was significantly higher in the case population. The number of completely edentulous patients was higher among the oral cancer population. The incidence of oral cancer was 57.1% in patients with periodontal disease. In comparison, the incidence of oral squamous cell carcinoma was only 28.6% among the patients without periodontitis. Most of the oral cancer patients (72.1%) had stage 4 periodontitis. On the other hand, the vast majority of the control group (51.6%) had stage 2 periodontitis. Conclusion Periodontitis can be an individual risk factor for oral cancer development. Periodontally compromised individuals should be strictly monitored, especially those with severe periodontitis and coexisting lifestyle risk factors. Maintaining their periodontal health in at-risk patients can minimize cancer risks.

Background Various surface treatment options have been adopted with the aim to improve osseointegration, reducing the overall treatment time. Implant stability of early loaded implants with different modified surfaces was compared in the present study. Methods Patients were selected from the Department of Oro-Maxillofacial Surgery and Stomatology at Semmelweis University. Patients randomly received SA (alumina sandblasted and acid-etched), NH (bioabsorbable apatite nanocoating) or SLA (large-grit sandblasted and acid-etched) surface implants. Outcome measures were: implant success, implant stability, and periodontal parameters. The implant stability was measured at the time of implant placement (primary stability) and six weeks after (prothesis delivery, secondary stability). Osstell and Periotest were applied to take all the measurements. The primary and secondary stability were compared in the three study groups Finally the periimplant probing depth appearing after three months of loading was checked on 6 points around to the implant-supported prostheses. Shapiro–Wilk and Mann–Whitney tests were used for the comparison between the study groups. Results A total of 75 implants with different length and diameter were inserted into various positions. One implant failed spontaneously at the fourth week after implant placement. The survival rate was 98,7%. Comparing the primary and secondary stability values, the data were significantly improved in every groups. The difference was the highest in the NH group, however, this difference was not significant compared to the two other groups. Good periodontal parameters were experienced in all the tested implants, independently by the groups. Conclusions With the limitation of the present study, all the implants showed improved stability six weeks after implant placement. A trend of higher result was found for the NH group. Further studies with longer follow-up are needed to confirm this preliminary results. Trial registration: Current Controlled Trials ISRCTN13181677; the date of registration: 04/03/2021. Retrospectively registered.

The etiological factors of squamous cell carcinomas of the head and neck have been well known for a long time. It is also well known that the incidence of oral cancer diagnosed in younger patients is on the rise. Due to the young age of these patients, the increase in the number of these cases and the fact that many of them neither smoke nor drink alcohol it has been suggested that other factors might be at play in the carcinogenesis of oral cancer. Thus, along the classic etiological factors of smoking and alcohol abuse certain molecular marker anomalies and the human papilloma virus (HPV) have emerged as potential factors. The aim of the present study is to verify the potential prognostic factors and to map the differences in biomarker expression between the young and the old patient groups. In the present study the immunohistochemical profile of samples obtained from oral squamous cell carcinomas was studied and compared with various clinico-pathological parameters. In 88 samples the expressions of p16, p53, Ki67, EGFR were studied with a tissue microarray technique under standard reaction conditions as well as the detection and typing of HPV infection with the Full Spectrum HPV DNA method. The biomarker expression profile of young patients with oral squamous cell carcinoma was compared to that of older patients (above 50). A significant difference was found between the immunohistochemical profile of the young and old patient groups in p16, Ki67 expression. The overall survival and progression free survival were influenced by p16 expression in young age.

A várandós páciensek fogászati kezelése néhány pontban eltér a nem várandósokétól. A fogorvos feladata az erre vonatkozó naprakész információk ismerete, melyek betartásával az anya és a magzat egészsége is megóvható. A várandós nőknek gyakrabban kell látogatniuk a fogorvosi szakrendelést, hiszen a megváltozott hormonális hatások fokozott rizikótjelentenek egyes fogászati kórképek kialakulására. Ezek felismerése és szakszerű ellátása kulcsfontosságú a terhesség során. Mind a kezelés menete, mind a szükséges gyógyszerelés nagyobb odafigyelést igényel a fogorvos részéről. A várandósok fogászati kezelését befolyásoló tényezőket és a magzati fejlődésre ható gyógyszereket számos tudományos kutatás célozza, ám a rendelkezésünkre álló információ még így is csekély. Cikkünkben a fogászati gyakorlatban használt gyógyszereket – antibiotikumok, fájdalomcsillapítók, helyi érzéstelenítők, gombaellenes készítmények, vírusellenes szerek, szorongáscsökkentők, szájfertőtlenítők és szájüregi ecsetelők – gyűjtöttük össze és összegeztük a várandósságban történő alkalmazhatóságukat az aktuális irányelvek alapján.

Bizonytalan eredetű periapikális elváltozások megjelenésénél gondolnunk kell a dentin dysplasia lehetőségére. Differenciáldiagnosztikai szempontból lényeges felismerni ezt az örökletes kórképet, mert ez jelentősen befolyásolja a pácienstovábbi kezelését. Ismeretlen etiológiájú anomáliáról van szó, ami megjelenhet mind a tej-, mind a maradó fogazatban,különböző klinikai és radiológiai eltéréseket okozva. Ebben a ritka, közel minden százezredik pácienst érintő elváltozásbanspontán kialakuló periapikális tályogok, illetve fog eredetű ciszták figyelhetők meg. Az érintett fogak mobilissá válhatnak,majd idővel azok elvesztését okozhatják. A dentin dysplasia (DD) olyan autoszomális domináns öröklődésmenetetmutató genetikai betegség, amelynek során a dentin fejlődése alatt strukturális elváltozás jön létre. A dentin dysplasiábanészlelhető fogazati elváltozások jelentős mértékben megnövelik a fogak idő előtti elvesztésének kockázatát, melyek funkcionálisés esztétikai hátrányokat okozva negatívan befolyásolják a páciensek pszichés állapotát és hátráltatják a társadalombavaló beilleszkedésüket. A szerzők a téma feldolgozásához a Pubmed elektronikus adatbázisában fellelhetőpublikációkat használták fel. Bemutatják egy családon belüli DD halmozódását.