Periodontitis as a risk for oral cancer: a case–control study

Komlós, György; Csurgay, Katalin; Horváth, Ferenc; Pelyhe, Liza; Németh, Zsolt

doi:10.1186/s12903-021-01998-y

Cited by 46 publications

(42 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, OPC mortality rates in males are expected to decline at the end of the period, while in females they will stabilize, except in those > 65 years where mortality rates are expected to rise. Therefore, our findings emphasized the need to maintain educational interventions aimed at the entire population in the coming years, promoting smoking cessation and alcohol abstinence, vaccination against HPV, campaigns for early diagnosis of potential malignant lesions in the oral cavity and oropharynx, changes in lifestyle, preservation of oral hygiene and periodontal health [17], and high consumption of fruits and vegetables. Our predictive model indicated that these preventive programs should be intensified especially in females in the near future.…”

Section: Discussionmentioning

confidence: 87%

Estimated projection of oral cavity and oropharyngeal cancer deaths in Spain to 2044

et al. 2022

View full text Add to dashboard Cite

Background Oral cavity cancer (OCC) and oropharyngeal cancer (OPC) are two common malignancies whose mortality is worryingly increasing worldwide. However, few studies have estimated the mortality trends for these cancers in the coming years. This study analysed the mortality rates for OCC and OPC observed between 1980 and 2019 to generate a predictive model for the next 25 years in Spain. Methods Mid-year population data and death certificates for the period 1980–2019 were obtained from the Spanish National Institute of Statistics. The Nordpred program (Norwegian Cancer Registry, Oslo, Norway) was used to calculate adjusted mortality rates as well as estimated mortality projections with an age-period-cohort model for the period 2020–2044. Results The specific mortality rate per 100,000 inhabitants for OCC decreased from 2.36 (1980–1984) to 2.17 (2015–2019) and is expected to decline to 1.68 (2040–2044), particularly in males. For OPC, mortality rates rose from 0.67 (1980–1984) to 1.23 (2015–2019) and are projected to drop to 0.71 (2040–2044). In the group of females > 65 years predictions showed rising mortality rates for both OCC and OPC. The predictive model projects more deaths in females than in males for OCC in the period 2040–2044, while deaths for OPC will decrease in males and gradually increase in females. Conclusions Although OCC mortality rates have been found to decrease in males in the last observed decades, there is still room to improve them in females > 65 years in the future by promoting campaigns against smoking and alcohol consumption. OPC mortality will become a growing health problem. Vaccination campaigns for the prevention of human papillomavirus-associated cancers may have a long-term impact on the mortality of these cancers, which should be evaluated in upcoming studies. Clinical relevance Our findings highlighted the importance of closely monitoring OCC and OPC mortality rates in the coming years by age group and sex, and the need to continue preventive measures against the main known risk factors, such as tobacco, alcohol, and human papillomavirus infection.

show abstract

Section: Discussionmentioning

confidence: 87%

Estimated projection of oral cavity and oropharyngeal cancer deaths in Spain to 2044

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The findings from our work also connected to the literature of periodontal disease. Periodontitis has been posited as a risk factor for oral cancer (Komlós et al, 2021 ). In connection with the preceding paragraph, species from Fusobacterium have been identified as having associations with periodontitis (Mohanty et al, 2019 ).…”

Section: Analysis Of Results and Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

Peter

Withanage²,

Comnick³

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

The intersection between the human oral microbiome and oral health is an emerging area of study which has gained momentum over the last decade. This momentum has motivated a search for associations between the oral microbiome and oral cancer, in hopes of identifying possible biomarkers that facilitate earlier diagnosis and improved prognosis for patients with that disease. The present study examined the relationship between the microbiome in the human oral cavity and oral squamous cell carcinoma (OSCC). We searched the literature for case-control studies which focused on the relationship between the human oral microbiome and OSCC. We aggregated three types of data from these studies: bacteriome data at the genus level, predicted functional pathway data, and gene abundance data. From these data, we noted several microbial genera which may be associated with oral cancer status, including Fusobacterium. We also identified functional pathways which merit further investigation, including RNA degradation (ko03018) and primary immunodeficiency (ko05340). In addition, our analysis of gene abundance data identified the gene K06147 (ATP-binding cassette, subfamily B, bacterial) as being over abundant in OSCC samples. Our results are generalizations which identified some currents that we believe could guide further research. Our work faced several limitations related to the heterogeneity of the available data. Wide variation in methods for sample collection, methods for controlling for known behavioral risk factors, computing platform choice, and methods for case-control design all posed confounding factors in this work. We examined the current methods of data collection, data processing, and data reporting in order to offer suggestions toward the establishment of best practices within this field. We propose that these limitations should be addressed through the implementation of standardized data analytic practices that will conform to the rigor and reproducibility standards required of publicly funded research.

show abstract

“…Actually, the causative and promotion role of P. gingivalis in oral cancers and in OSCC appears confirmed in recent reports and meta-analyses ( 24 , 25 ). As P. gingivalis is the major causative microbial agent of periodontitis ( 26 ), therefore its association with oral cancers pertains to the direct association with previous gum and dental hygiene impairments leading to periodontitis ( 5 , 27 ), and this may be beyond the purpose of our report.…”

Section: The Oral Microbiome Composition In the Hygiene Perspective O...mentioning

confidence: 93%

“…Moreover, teeth and gums associated pathologies, e.g. periodontitis, seem to be a leading cause of oropharyngeal cancers, although lifestyle and voluptuary habits, associated with age, sex, smoke, tobacco and alcohol abuse, have to be included in the causative group of factors ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Oral microbiota in oropharyngeal cancers: Friend or foe?

Nocini

Muzio²,

Gibellini³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

Oral microbiome is a complex population of micro-organisms, which by cross-talking with the local immune system, plays a major role in the immune homeostasis of the oral cavity, further contributing in the physiology of the gastro-intestinal microbiota. Understanding their involvement in the onset and pathogenesis of oropharyngeal cancers is paramount, despite very few reports deal with the fundamental role exerted by oral microbiota disorders, such as dysbiosis and impairment in the oral microbiome composition as causative factors in the development of oropharyngeal tumors. Current research, via metabolomic or meta-transcriptomic analyses, is wondering how this complex microbial population regulates the immune homeostasis in oral and pharyngeal mucosa and whether changes in bacterial composition may give insights on the role of oral microbiome in the development of oropharyngeal tumors, so to prevent their occurrence.

show abstract

Periodontitis as a risk for oral cancer: a case–control study

Cited by 46 publications

References 43 publications

Estimated projection of oral cavity and oropharyngeal cancer deaths in Spain to 2044

Estimated projection of oral cavity and oropharyngeal cancer deaths in Spain to 2044

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

Oral microbiota in oropharyngeal cancers: Friend or foe?

Contact Info

Product

Resources

About