A review of bioresorbable scaffolds: hype or hope?

Tan, Huay Cheem; Ananthakrishna, Rajiv

doi:10.11622/smedj.2016178

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…The strut thickness of the BVS may result in frequent side-branch occlusions and result in periprocedural myocardial infarction. Early causes of BVS failure include scaffold dislodgement, acute recoil, and scaffold thrombosis 51. The concept of the BVS is attractive.…”

Section: Discussionmentioning

confidence: 99%

Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents

Yang¹,

Chang²,

Webster³

2019

IJN

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Background and purposeA coronary stent is a well-known cardiovascular medical device implanted to resolve disorders of the circulatory system due to bloodstream narrowing. Since the implanted device interacts with surrounding biological environments, the surface properties of a typical implantable stent play a critical role in its success or failure. Endothelial cell adhesion and proliferation are fundamental criteria needed for the success of a medical device. Metallic coronary stents are commonly used as biomaterial platforms in cardiovascular implants. As a new generation of coronary stents, bioresorbable vascular scaffolds have attracted a great deal of attention among researchers and studies on bioresorbable materials (such as magnesium and zinc) remain a target for further optimization. However, additional surface modification is needed to control the biodegradation of the implant material while promoting biological reactions without the use of drug elution.MethodsHerein, precise temperature and thickness controlled atomic layer deposition (ALD) was utilized to provide a unique and conformal nanoscale TiO2 coating on a customized magnesium-zinc stent alloy.ResultsImpressively, results indicated that this TiO2 nano-thin film coating stimulated coronary arterial endothelial cell adhesion and proliferation with additional features acting as a protective barrier. Data revealed that both surface morphology and surface hydrophilicity contributed to the success of the ALD nanoscale coating, which further acted as a protection layer inhibiting the release of harmful degradation products from the magnesium-zinc stent.ConclusionOverall, the outcome of this in vitro study provided a promising ALD stent coating with unique nano-structural surface properties for increased endothelialization, and as a result, ALD should be further studied for numerous biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents

Yang¹,

Chang²,

Webster³

2019

IJN

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“…Also, the implanted BMS and DES need regular monitoring and long-term antiplatelet therapy to prevent blood clots [8][9][10]. To address these issues, many bioresorbable scaffolds (BRSs) have been reported with excellent degradability [11,12]. Over the years, several BRS have been proposed using polycaprolactone (PCL), polylactide, polyglycolide, and polylactic-co-glycolic acid by various advanced techniques, including additive manufacturing technology [11].…”

Section: Introductionmentioning

confidence: 99%

“…To address these issues, many bioresorbable scaffolds (BRSs) have been reported with excellent degradability [11,12]. Over the years, several BRS have been proposed using polycaprolactone (PCL), polylactide, polyglycolide, and polylactic-co-glycolic acid by various advanced techniques, including additive manufacturing technology [11]. Among several biodegradable materials, PCL received considerable attention for BRS owing to its attractive advantages such as high mechanical stability and simple fabrication process for complex designs [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Additive manufactured cardiovascular scaffold integrated with SU-8 based wireless pressure sensor

Sun¹,

Kim²,

Shanmugasundaram³

et al. 2022

J. Micromech. Microeng.

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Herein, we proposed a SU-8 based wireless pressure sensor integrated with a polycaprolactone (PCL) based bioresorbable scaffold (BRS) for the detection of biological cues. The PCL-based BRS and pressure sensor are fabricated using a custom-designed additive manufacturing method and a modified photolithography technique. Firstly, we optimized the additive manufacturing fabrication parameters to realize the highly reliable scaffold with uniform strut width and thickness. Then, utilizing the optimized additive manufacturing conditions, we fabricated three distinct types of scaffolds, namely scaffold A, scaffold B, and scaffold C, each with a unique architecture. The preliminary characteristics of the fabricated scaffolds demonstrated that the scaffold A architecture exhibited superior properties, including 0.048 N mm-1 radial force, 1.64% foreshortening, and 14.1% recoil compared to the scaffolds B and C. The LC-pressure sensor is integrated into the PCL-based BRS using a water-soluble polyvinyl alcohol (PVA) adhesive layer. The reliability of the fabricated LC-pressure sensor is confirmed by measuring its change capacitance and resonance frequency at different applied pressures. The proposed LC-pressure sensor integrated PCL-based BRS is evaluated in a pressure range of 0 to 280 mmHg. The resonant frequency of the fabricated smart scaffold changed linearly according to the pressure change indicating the high reliability of the proposed smart scaffold. We anticipate that the proposed pressure sensor integrated with the biodegradable PCL-based BRS would be used for biomedical applications owing to their facile fabrication process and excellent sensitivity.

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“…Bioresorbable (or, equivalently, bioabsorbable) organic and inorganic materials serve as the basis for biomedical implants that chemically react in a controlled manner with biofluids to yield soluble and biocompatible end products. [ 1–5 ] The interest is in devices that serve temporary functions in the body in the context of transient biological processes such as wound healing. [ 6–9 ] Mechanisms of bioresorption naturally eliminate a potential source of infectionand of other complications, as well as risks and costs associated with secondary surgical procedures for retrieval.…”

Section: Introductionmentioning

confidence: 99%

Bioresorbable Metals for Biomedical Applications: From Mechanical Components to Electronic Devices

Ryu

Seo

2021

Adv Healthcare Materials

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Bioresorbable metals and metal alloys are of growing interest for myriad uses in temporary biomedical implants. Examples range from structural elements as stents, screws, and scaffolds to electronic components as sensors, electrical stimulators, and programmable fluidics. The associated physical forms span mechanically machined bulk parts to lithographically patterned conductive traces, across a diversity of metals and alloys based on magnesium, zinc, iron, tungsten, and others. The result is a rich set of opportunities in healthcare materials science and engineering. This review article summarizes recent advances in this area, starting with an historical perspective followed by a discussion of materials options, considerations in biocompatibility, and device applications. Highlights are in system level bioresorbable electronic platforms that support functions as diagnostics and therapeutics in the context of specific, temporary clinical needs. A concluding section highlights challenges and emerging research directions.

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A review of bioresorbable scaffolds: hype or hope?

Cited by 7 publications

References 44 publications

<p>Atomic Layer Deposition Coating of TiO<sub>2</sub> Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents</p>

<p>Atomic Layer Deposition Coating of TiO<sub>2</sub> Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents</p>

Additive manufactured cardiovascular scaffold integrated with SU-8 based wireless pressure sensor

Bioresorbable Metals for Biomedical Applications: From Mechanical Components to Electronic Devices

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