A review of contralateral responses to a unilateral inflammatory lesion

Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain

“…Contralateral mirror-imaging has been experimentally demonstrated in a variety of injuries in laboratory animals: inflammatory cutaneous and joint (reviewed in Shenker et al 2003), inflammatory and non-inflammatory muscle Radhakrishnan et al 2003) and neuropathic (reviewed in Koltzenburg et al 1999). Altered contralateral sensory perception after unilateral injury or in chronic pain syndromes is reported as well in clinics (Huge et al 2008;de la Llave-Rincón et al 2009;Fernández-de-las-Peñas et al 2009;Konopka et al 2012;Werner et al 2013).…”

“…Treatment varies from case to case and there is no consent. Based on experimental research, it is speculated that mechanisms of contralateral spread of pain involve yet unidentified spinal neural pathways (reviewed by Koltzenburg et al 1999;Shenker et al 2003;Huang and Yu 2010; Janalcek 2011) with critical contribution of deregulated supraspinal descending pathways (Tillu et al 2008;Radhakrishnan and Sluka 2009). Antinociceptive effect of botulinum toxin type A (BT-A) was investigated in several MP models such as non-inflammatory muscle pain induced by repeated acidic saline intramuscular injection (Bach-Rojecky and Lacković 2009), trigeminal neuropathy induced by unilateral infraorbital nerve constriction injury (IoNC) (Filipović et al 2012) and inflammatory pain induced by complete Freund's adjuvant (CFA) injection into temporomandubular joint (Lacković et al 2016).…”

The possible role of embryonic polarity axes for the normalization of tissue function induced by the interaction between human bilateral parts

“…Hand remedy administration Improved or cured Self Therapist The bilateral hip joint pain of one case was also relieved with ipsilateral hand The mechanism of action of Ou HR and OuDP remain unclear, but the potential roles of several sensory factors merit exploration because studies have shown inflammation proceeding bilaterally may occur through neurological transmission [2,3]. When the HR is performed, the treated area perceives the hand not only by proprioception or touch, but also by temperature changes.…”

“…Other studies have shown that the mutual interaction of bilateral topographically symmetrical features of mammals may also induce and reinforce inflammatory reactions and pain sensations on the contralateral side of the body. Examples of such a phenomenon are contralateral arthritis induced by unilateral arthritis in rats, and symmetrical development of arthritis, pulmonary fibrosis, glomerulonephritis, and sympathetic ophthalmia in humans [3]. The mechanisms involved in the mutual interaction between bilateral parts of topographically symmetrical living beings remain largely unknown, though there are indications that such interaction may occur through neurological transmission [3].…”

Central Sensitization and Descending Facilitation in Chronic Pain State

“…In the literature, we can find many examples of bilateral hyperalgesia and allodynia due to unilateral neuropathy (Erichsen & Blackburn-Munro, 2002;Li et al, 2006Yasuda et al, 2005Yu et al, 1996;), cancer pain (Mao-Ying et al, 2006) or inflammation (Milligan et al, 2003(Milligan et al, , 2005Shenker, 2003;Schreiber et al, 2008) in animal models and neuropathic pain (Becerra L et al, 2006;Hatashita et al, 2008;Wasner et al, 2008 ) , capsaicin-induced experimental pain (Shenker et al, 2008) and toothache (Khan et al, 2007 ) in human cases (for review see Huang and Yu, 2010). An experimental pain induced by unilateral intramuscular injection of low pH saline caused bilateral long-lasting hyperalgesia in rats (Sluka et al, 2001).…”