A Review of Cyclodextrin Encapsulation and Intelligent Response for the Release of Curcumin

Li, Jing; Xu, Fang; Dai, Yujie; Zhang, Jiawen; Yuan, Shyan-Ming; Lai, Danning; Sriboonvorakul, Natthida; Hu, Jiamiao

doi:10.3390/polym14245421

Cited by 20 publications

(7 citation statements)

References 115 publications

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“…The encapsulation of active compounds from Melissa officinalis leaves in β-cyclodextrin and modified starch was equally successful [ 55 ]. The effectiveness of other cyclodextrins in the encapsulation process was demonstrated in a review paper by Li et al [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects

Gościniak,

Rosiak,

Szymanowska

et al. 2024

Pharmaceutics

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Pomegranate flower extract, rich in anthocyanins, demonstrates beneficial health-promoting properties such as an anti-diabetic and antioxidant effect, among others. However, the potential health-promoting properties may be hindered by the low stability of anthocyanins. Therefore, the aim of our study was to assess whether stabilizing carriers, namely HP-γ-cyclodextrin (HP-γ-CD), α-cyclodextrin (α-CD), Methyl-β-cyclodextrin (Me-β-CD), Inulin (Inu) and Arabic gum (AGu) affect the antioxidant and antidiabetic activity of lyophilized pomegranate flower extract, how they influence stability, release profile, and whether the systems exhibit prebiotic activity. Interactions between pomegranate flower extract and these factors were analyzed using FT-IR. The structures were examined through microscopic imaging while for the prepared prebiotic systems, antidiabetic activity was determined and confirmed by the inhibition of α-amylase and α-glucosidase; antioxidant activity was expressed by DPPH and CUPRAC assays. The content of pelargonidin-3,5-glucoside in these systems was assessed using the HPLC method. The release profiles of pelargonidin-3,5-glucoside were examined in a medium at pH = 6.8 and pH = 1.2, and the stability was assessed after subjecting the systems to high temperatures (T = 90 °C). The prebiotic potential was evaluated for 10 prebiotic bacterial strains (Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus brevis Lactobacillus rhamnosus gg, Lactobacillus reuteri, Pediococcus pentosaceus, Lactococcus lactis, Lactobacillus fermentum lf, Streptococcus thermophilus). As a result of the conducted research, better functionalities of the obtained systems containing Pomegranate flower extract were proven in terms of prebiotic and antidiabetic effects. The obtained delivery systems for pelargonidin-3,5-glucoside allow for better use of its health-promoting effects.

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Section: Resultsmentioning

confidence: 99%

Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects

Gościniak,

Rosiak,

Szymanowska

et al. 2024

Pharmaceutics

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“…Cyclodextrins are characterised by their hydrophilic circular truncated cone shape. When combined with a molecule, cyclodextrins can easily form a host-guest supramolecular complex [ 135 ]. This cone shape has a hydrophobic hollow conical cavity with a depth of 7.9 Å [ 136 ].…”

Section: Wall Materials: Natural Polymer Coatingsmentioning

confidence: 99%

“…This method provided a light-yellow, fluffy powder with excellent aqueous solubility. After the incorporation of curcumin, the complex was encapsulated in chitosan to ensure the transport to human skin cancer cells, which showed higher cytotoxicity [ 135 ].…”

Section: Wall Materials: Natural Polymer Coatingsmentioning

confidence: 99%

Encapsulation of Active Substances in Natural Polymer Coatings

Akpo,

Colin,

Perrin

et al. 2024

Materials

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Already used in the food, pharmaceutical, cosmetic, and agrochemical industries, encapsulation is a strategy used to protect active ingredients from external degradation factors and to control their release kinetics. Various encapsulation techniques have been studied, both to optimise the level of protection with respect to the nature of the aggressor and to favour a release mechanism between diffusion of the active compounds and degradation of the barrier material. Biopolymers are of particular interest as wall materials because of their biocompatibility, biodegradability, and non-toxicity. By forming a stable hydrogel around the drug, they provide a ‘smart’ barrier whose behaviour can change in response to environmental conditions. After a comprehensive description of the concept of encapsulation and the main technologies used to achieve encapsulation, including micro- and nano-gels, the mechanisms of controlled release of active compounds are presented. A panorama of natural polymers as wall materials is then presented, highlighting the main results associated with each polymer and attempting to identify the most cost-effective and suitable methods in terms of the encapsulated drug.

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“…[40] Due to its high hydrophobicity, Cur exhibits low serum and plasma levels, constrained biodistribution, rapid metabolism, and fast elimination from the body. [41] To improve both Cur physicochemical and pharmacokinetic properties have been designed and developed different strategies, including the use of cyclodextrins, [42][43][44][45] however, to the best of our knowledge, nothing has been described about the formation of complexes by mechanochemistry between Cur and CDs.…”

Section: Introductionmentioning

confidence: 99%

Inclusion and Non‐Inclusion Complexes between Curcumin and β‐Cyclodextrin with High‐Curcumin Loading and Enhanced Aqueous Solubility Obtained by Mechanochemistry

Cabrera‐Quiñones,

López‐Méndez,

Guadarrama

2023

ChemistrySelect

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In this study, we employ mechanochemistry as an innovative strategy, using a Planetary Mill, to obtain supramolecular structures in the solid state between Curcumin (Cur) and β‐cyclodextrin (βCD), exploring different parameters such as jars and balls material (stainless steel versus zirconium oxide), milling time, as well as the effect on imposing different Cur:βCD molar ratios. Our findings demonstrate that regardless of the milling material used, the same supramolecular interactions between Cur and βCD seem to be promoted. However, depending on the molar ratio, different supramolecular modes are produced resulting in inclusion complexes (ICs) or non‐inclusion complexes (non‐ICs) by a partial or total amorphization of both Cur and βCD. Independently of the type of supramolecular complex obtained (ICs/or non‐ICs), high content of Cur was quantified in all the systems, achieving a Cur content of up to 342 mg per mmol of βCD, along with an enhancement in Cur aqueous solubility. The Cur:βCD 1 : 2 complex showed the highest aqueous solubility (around 10‐times more soluble than milled Cur). In our conditions, the optimum time to form the supramolecular complexes was 60 min. The stability of the complexes was directly related to the extent of encapsulation of Cur inside the βCD cavity.

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A Review of Cyclodextrin Encapsulation and Intelligent Response for the Release of Curcumin

Cited by 20 publications

References 115 publications

Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects

Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects

Encapsulation of Active Substances in Natural Polymer Coatings

Inclusion and Non‐Inclusion Complexes between Curcumin and β‐Cyclodextrin with High‐Curcumin Loading and Enhanced Aqueous Solubility Obtained by Mechanochemistry

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