A review of dietary stilbenes: sources and bioavailability

Khawand, Toni El; Courtois, Arnaud; Valls, Josep; Richard, Tristan; Krisa, Stéphanie

doi:10.1007/s11101-018-9578-9

Cited by 135 publications

(80 citation statements)

References 80 publications

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“…Stilbenoids are a group of plant phytoalexins occurring in various edible and medicinal plants. Currently, more than 400 derivatives of stilbene have been identified [1]. Among these, the most well-known is trans-resveratrol, which is found in grapes (Vitis vinifera L.) and therefore red wine, peanuts (Arachis hypiogaea L.), and in a wide range of berries (genus Vaccinium L.) [2,3].…”

Section: Introductionmentioning

confidence: 99%

Metabolism of cis- and trans-Resveratrol and Dihydroresveratrol in an Intestinal Epithelial Model

et al. 2020

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Trans-resveratrol, a well-known plant phenolic compound, has been intensively investigated due to its association with the so-called French paradox. However, despite its high pharmacological potential, trans-resveratrol has shown relatively low bioavailability. Trans-resveratrol is intensively metabolized in the intestine and liver, yielding metabolites that may be responsible for its high bioactivity. The aim of this study was to investigate and compare the metabolism of trans-resveratrol (tRes), cis-resveratrol (cRes) and dihydroresveratrol (dhRes) in an in vitro epithelial model using Caco-2 cell lines. Obtained metabolites of tRes, cRes and dhRes were analyzed by LC/MS Q-TOF, and significant differences in the metabolism of each compound were observed. The majority of tRes was transported unchanged through the Caco-2 cells, while cRes was mostly metabolized. The main metabolite of both cis- and trans-resveratrol observed as a result of colon microbial metabolism, dhRes, was metabolized almost completely, with only traces of the unchanged molecule being found. A sulphate conjugate was identified as the main metabolite of tRes in our model, while a glucuronide conjugate was the major metabolite of cRes and dhRes. Since metabolism of simple phenolics and polyphenols plays a crucial role in their bioavailability, detailed knowledge of their transformation is of high scientific value.

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Section: Introductionmentioning

confidence: 99%

Metabolism of cis- and trans-Resveratrol and Dihydroresveratrol in an Intestinal Epithelial Model

et al. 2020

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“…The health benefits of polyphenols such as stilbenes have been reviewed by Rasouli, Farzaei, and Khodarahmi (2017). The sources and bioavailability of dietary stilbenes have also been reviewed by El Khawand, Courtois, Valls, Richard, Courtois, Valls, Richard, and Krisa (2018). These reviews were, however, limited to a single class of phenolic compounds and their health benefits.…”

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confidence: 99%

Concept, mechanism, and applications of phenolic antioxidants in foods

2020

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In this review, the concept of phenolic antioxidants, mechanisms of action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety of free radicals. The mechanism of antioxidant actions involved either by hydrogen atom transfer, transfer of a single electron, sequential proton loss electron transfer, and chelation of transition metals. In foods, the PCs act as antioxidants which are measured with several in vitro spectroscopic methods. The PCs have been found in milk and a wide range of dairy products with sole purposes of color, taste, storage stability, and quality enhancement. The role of PCs in three types of food additives, that is, antimicrobial, antioxidant, and flavoring agents have been critically reviewed. The literature revealed that PCs present in a variety of foods possess several health benefits such as antibacterial, antihyperlipidemic, anticancer, antioxidants, cardioprotective, neuroprotective, and antidiabetic properties. Practical applications Phenolic compounds are strong antioxidants and are safer than synthetic antioxidants. The wide occurrence in plant foods warranted continuous review applications. This review, therefore, presented an updated comprehensive overview of the concept, mechanism, and applications of phenolic antioxidants in foods.

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“…Stilbenes are reported to be present in grapes, almond, bean, blueberries, bilberries, peanuts, grapevine, cranberries, mulberries, plum, and wine (Arraki et al, ; Błaszczyk, Sady, & Sielicka, ; Chang, Alasalvar, Bolling, & Shahidi, ; Hassan, Saleh, & AbdElgawad, ; Shrikanta, Kumar, & Govindaswamy, ). The recent review of El Khawand, Courtois, Valls, Richard, and Krisa () remarked how stilbenes present a high diversity in their phenolic structures (various chemical substituents and polymerization), which is a determining factor for their absorption and metabolism rates (El Khawand et al, ). The review of Reinisalo, Kårlund, Koskela, Kaarniranta, and Karjalainen () summarized studies on the molecular mechanisms involved in the stilbene‐mediated protection against oxidative stress in age‐related diseases; the Nrf2/ARE pathway and cAMP second messenger system together are the key regulators of cellular antioxidant defence.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

“…The recent review of ElKhawand, Courtois, Valls, Richard, and Krisa (2018) remarked how stilbenes present a high diversity in their phenolic structures (various chemical substituents and polymerization), which is a determining factor for their absorption and metabolism rates(El Khawand et al, 2018). The review ofReinisalo, Kårlund, Koskela, Kaarniranta, and Karjalainen (2015) summarized studies on the molecular mechanisms involved in the stilbene-mediated protection against oxidative stress in age-related diseases; the Nrf2/ARE pathway and cAMP second messenger system together are the key regulators of cellular antioxidant defence.…”

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confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

611

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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A review of dietary stilbenes: sources and bioavailability

Cited by 135 publications

References 80 publications

Metabolism of cis- and trans-Resveratrol and Dihydroresveratrol in an Intestinal Epithelial Model

Metabolism of cis- and trans-Resveratrol and Dihydroresveratrol in an Intestinal Epithelial Model

Concept, mechanism, and applications of phenolic antioxidants in foods

Polyphenols: A concise overview on the chemistry, occurrence, and human health

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