A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian, Hossein; Lemraski, Ensieh Ghasemian; Webster, Thomas J.; Rafiee-Moghaddam, Roshanak; Abdollahi, Yadollah

doi:10.2147/ijn.s127683

Cited by 449 publications

(237 citation statements)

References 106 publications

(83 reference statements)

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“…A wide range of drug delivery systems (DDS) have been proposed to improve in one way or another (solubility, stability, pharmacodynamics, pharmacokinetics, biodistribution…) the performance of conventional drugs . Solid lipid nanoparticles (SLNs) were first formulated in the 1980s and since then have been the subject of a lot of research as they present a number of advantages over other DDS.…”

Section: Introductionmentioning

confidence: 63%

Magnetic Hybrid Wax Nanocomposites as Externally Controlled Theranostic Vehicles: High MRI Enhancement and Synergistic Magnetically Assisted Thermo/Chemo Therapy

Moura¹,

Gallo

García‐Hevia

et al. 2020

Chemistry A European J

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To fight against cancer, smarter drugs and drug delivery systems are required both to boost the efficiency of current treatments while reducing deleterious side effects, and combine diagnosis/monitoring with therapy (theranosis) in the search for the final goal of personalized medicine. This work presents the design, preparation, and proof‐of‐principle validation of a novel hybrid organic–inorganic nanocomposite joining together non‐invasive imaging capabilities through magnetic resonance imaging and externally actuated therapeutic properties through a combination of chemo‐ and thermotherapy. The lipidic matrix of the nanocomposite was composed of carnauba wax, which was simultaneously dual loaded with magnetite nanoparticles and the anticancer drug Oncocalyxone A. Obtained formulations were fully characterized and showed outstanding performances as T2‐contrast agents in magnetic resonance imaging (r2>800 mm−1 s−1), heat generating sources in magnetic hyperthermia (specific absorption rate, SAR>200 W g−1Fe), and magnetically responsive drug delivery vehicles. The potential of the designed formulations as theranostic agents was validated in vitro and results indicated a synergistic thermo/chemotherapeutic effect derived from heat generation and controlled drug delivery to cancer growth. Thereby, this external control over the drug delivery profile and the integrated imaging capability open the door to personalized cancer medicine and real‐time monitoring of tumor progression.

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Section: Introductionmentioning

confidence: 63%

Magnetic Hybrid Wax Nanocomposites as Externally Controlled Theranostic Vehicles: High MRI Enhancement and Synergistic Magnetically Assisted Thermo/Chemo Therapy

Moura¹,

Gallo

García‐Hevia

et al. 2020

Chemistry A European J

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“…With the advent of nanomedicine, the preparation of nanoparticles for pharmaceutical applications has been widely applied for medical diagnostics and drug delivery . Nanoparticles can be prepared by a wide variety of chemical or physical methods.…”

Section: Introductionmentioning

confidence: 99%

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Jenjob

Phakkeeree

Seidi

et al. 2019

Macromolecular Bioscience

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Nanoparticles have the advantages over micron‐sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Selection of techniques, such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, and emulsion‐solvent evaporation processes, strongly influences morphologies, size distributions, and particle properties. Details in the synthetic strategies governing the performance of nanoparticles in bioimaging, biosensing, and drug delivery are presented. Benefits and limitations of molecular imaging techniques are also discussed.

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“…A wide range of polysaccharide-based NPs with antimicrobial and antiviral properties have been synthesized and documented in the literature [42]. Infections caused by bacteria, viruses, parasites, or fungi are major human health risks.…”

Section: Antimicrobial Properties Of Aunpsmentioning

confidence: 99%

Green synthesis of polysaccharide-based inorganic nanoparticles and biomedical aspects

Shavandi¹,

Saeedi

Ali

et al. 2019

Functional Polysaccharides for Biomedical Applications

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A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Cited by 449 publications

References 106 publications

Magnetic Hybrid Wax Nanocomposites as Externally Controlled Theranostic Vehicles: High MRI Enhancement and Synergistic Magnetically Assisted Thermo/Chemo Therapy

Magnetic Hybrid Wax Nanocomposites as Externally Controlled Theranostic Vehicles: High MRI Enhancement and Synergistic Magnetically Assisted Thermo/Chemo Therapy

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Green synthesis of polysaccharide-based inorganic nanoparticles and biomedical aspects

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