A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics

Sun, Jiachen; Fang, Runcheng; Wang, Hua; Xu, De-Xiang; Yang, Jing; Huang, Xiaochen; Cozzolino, Daniel; Fang, Mingliang; Huang, Yichao

doi:10.1016/j.envint.2021.106941

Cited by 107 publications

(41 citation statements)

References 118 publications

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“…have shown that human gut microbiota can regulate the sleep and mental states of the host and that the emotional states also affect the composition of gut microbes, suggesting an important role of the brain-gut microbiota axis in human health ( Li et al., 2018 ). Also, gut microbiota regulates the synthesis of neuroactive molecules, such as acetylcholine, catecholamines, γ-aminobutyric acid, histamine, melatonin, and serotonin ( Petra et al., 2015 ), which may also be influenced by environmental stressors ( Huang and Fang, 2020 ; Sun et al., 2022 ). For example, gut microbiota modulates the synthesis of neurotransmitter 5-hydroxytryptamine (5-HT) in the CNS through the kynurenine pathway.…”

Section: Introductionmentioning

confidence: 99%

Alterations in Gut Microbiota Are Correlated With Serum Metabolites in Patients With Insomnia Disorder

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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This study aimed to investigate insomnia-related alterations in gut microbiota and their association with serum metabolites. A total of 24 patients with insomnia disorder and 22 healthy controls were recruited. The fecal and serum samples were collected. The 16s rRNA sequencing and bioinformatics analysis were conducted to explore insomnia-related changes in the diversity, structure, and composition of the gut microbiota. UPLC-MS was performed to identify insomnia-related serum metabolites. Spearman correlation analysis was used to investigate the correlations between insomnia-related gut bacteria and the serum metabolites. Despite the nonsignificant changes in the diversity and structure of gut microbiota, insomnia disorder patients had significantly decreased family Bacteroidaceae, family Ruminococcaceae, and genus Bacteroides, along with significantly increased family Prevotellaceae and genus Prevotella, compared with healthy controls. Genus Gemmiger and genus Fusicatenibacter were dominant in patients with insomnia disorder, whereas genus Coprococcus, genus Oscillibacter, genus Clostridium XI, and family Peptostreptococcaceae were dominant in healthy controls. The UPLC-MS analysis identified 97 significantly decreased metabolites and 74 significantly increased metabolites in the serum samples of patients with insomnia disorder, compared with those of healthy controls. KEGG enrichment analysis revealed 1 significantly upregulated metabolic pathway and 16 downregulated metabolic pathways in patients with insomnia disorder. Furthermore, Spearman correlation analysis unveiled significant correlations among the altered bacteria genus and serum metabolites. Patients with insomnia disorder have differential gut microbiota and serum metabolic profiles compared with healthy controls. The alterations in gut microbiota were correlated with specific serum metabolites, suggesting that some serum metabolites might mediate gut microbiota-brain communication in the pathogenesis of insomnia disorder.

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Section: Introductionmentioning

confidence: 99%

Alterations in Gut Microbiota Are Correlated With Serum Metabolites in Patients With Insomnia Disorder

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Environmental stresses cause excessive ROS, which induces cellular oxidative damage [ 49 , 50 ], ISC activation and tissue renewal [ 51 ]. Recent studies revealed that UA could significantly alleviate the ROS production and cell death induced by a mycotoxin ochratoxin A [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling

Tian

et al. 2022

Antioxidants

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Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying mechanism has not been well clarified in vivo. Here, using a Drosophila UC model induced by sodium dodecyl sulfate (SDS), we investigated the defensive effect of UA on intestinal damage. The results showed that UA could significantly protect Drosophila from the damage caused by SDS exposure. Further, UA alleviated the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by SDS and upregulated the activities of total superoxide dismutase (T-SOD) and catalase (CAT). Moreover, the proliferation and differentiation of intestine stem cells (ISCs) as well as the excessive activation of the c-Jun N-terminal kinase (JNK)-dependent JAK/STAT signaling pathway induced by SDS were restored by UA. In conclusion, UA prevents intestine injury from toxic compounds by reducing the JNK/JAK/STAT signaling pathway. UA may provide a theoretical basis for functional food or natural medicine development.

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“…In the literature, it has been reported that in children and adolescents PFAS levels were higher at the onset of diabetes than in healthy controls. It has also been hypothesized that prenatal exposure to PFAS causes alteration of the lipid profile in infants, which in itself could increase the risk of insular autoimmunity in T1DM [ 13 , 15 , 16 ].…”

Section: Pancreatic Beta-cellsmentioning

confidence: 99%

“…The National Health and Nutrition Examination Survey (NHANES) database cross-sectionally analyzed 1721 adults (see NHANES and Observational Studies) reporting a positive association between diabetes and serum levels of 19 different persistent pollutants (including organochlorine pesticides, OCPs) [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System

Guarnotta

Amodei

Frasca

et al. 2022

IJMS

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There is growing concern regarding the health and safety issues of endocrine-disrupting chemicals (EDCs). Long-term exposure to EDCs has alarming adverse health effects through both hormone-direct and hormone-indirect pathways. Non-chemical agents, including physical agents such as artificial light, radiation, temperature, and stress exposure, are currently poorly investigated, even though they can seriously affect the endocrine system, by modulation of hormonal action. Several mechanisms have been suggested to explain the interference of EDCs with hormonal activity. However, difficulty in quantifying the exposure, low standardization of studies, and the presence of confounding factors do not allow the establishment of a causal relationship between endocrine disorders and exposure to specific toxic agents. In this review, we focus on recent findings on the effects of EDCs and hormone system modulators on the endocrine system, including the thyroid, parathyroid glands, adrenal steroidogenesis, beta-cell function, and male and female reproductive function.

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A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics

Cited by 107 publications

References 118 publications

Alterations in Gut Microbiota Are Correlated With Serum Metabolites in Patients With Insomnia Disorder

Alterations in Gut Microbiota Are Correlated With Serum Metabolites in Patients With Insomnia Disorder

Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling

Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System

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