A review of experimental infections with bluetongue virus in the mammalian host

Coetzee, Peter; Vuuren, Moritz Van; Venter, Estelle Hildegard; Stokstad, Maria

doi:10.1016/j.virusres.2013.12.044

Cited by 37 publications

(50 citation statements)

References 134 publications

(169 reference statements)

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“…Increased densities of red deer during the rutting season (late September to early winter), coupled with the fights between stags which occur at that period, provide favourable conditions for virus transmission between individuals and the subsequent invasion of Bluetongue Virus into naïve red deer populations. Further, the long-term viraemia of the hosts, which has been experimentally documented and the detection of virus in lymphoid organs for up to eight months support a potential for long-term transmission of Bluetongue Virus (Coetzee et al, 2014). One should also take into account the seasonal migrations of red deer, which can play a role in introducing the virus in domestic or other wild susceptible hosts.…”

Section: Potential Role Of Wild Ruminants In the Expansion Of Bluetonguementioning

confidence: 99%

Bluetongue Virus in wild ruminants in Europe: Concerns and facts, with a brief reference to bluetongue in cervids in Greece during the 2014 outbreak

Chatzopoulos

Valiakos

Γιαννακόπουλος

et al. 2015

Small Ruminant Research

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Section: Potential Role Of Wild Ruminants In the Expansion Of Bluetonguementioning

confidence: 99%

Bluetongue Virus in wild ruminants in Europe: Concerns and facts, with a brief reference to bluetongue in cervids in Greece during the 2014 outbreak

Chatzopoulos

Valiakos

Γιαννακόπουλος

et al. 2015

Small Ruminant Research

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“…As previously shown, rBTV/-2 displayed reduced replication kinetics compared to those of the two other BTV reassortant viruses, both in IFN-competent and -deficient ovine cells. Hence, IFNAR Ϫ/Ϫ mice represent a relevant experimental model to assess the effect of P24 on in vivo properties of BTV (67,77,78). IFNAR Ϫ/Ϫ mice were intraperitoneally inoculated with the three Seg-10 reassortant BTV viruses, rBTV/-1, rBTV/-2, and rBTV/-2PL, and their clinical signs and survival rates was observed daily up to 14 days p.i.…”

Section: Resultsmentioning

confidence: 99%

Turnover Rate of NS3 Proteins Modulates Bluetongue Virus Replication Kinetics in a Host-Specific Manner

Ftaich

Ciancia

Viarouge

et al. 2015

J Virol

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Bluetongue virus (BTV) is an arbovirus transmitted to livestock by midges of the Culicoides family and is the etiological agent of a hemorrhagic disease in sheep and other ruminants. In mammalian cells, BTV particles are released primarily by virus-induced cell lysis, while in insect cells they bud from the plasma membrane and establish a persistent infection. BTV possesses a ten-segmented double-stranded RNA genome, and NS3 proteins are encoded by segment 10 (Seg-10). The viral nonstructural protein 3 (NS3) plays a key role in mediating BTV egress as well as in impeding the in vitro synthesis of type I interferon in mammalian cells. In this study, we asked whether genetically distant NS3 proteins can alter BTV-host interactions. Using a reverse genetics approach, we showed that, depending on the NS3 considered, BTV replication kinetics varied in mammals but not in insects. In particular, one of the NS3 proteins analyzed harbored a proline at position 24 that leads to its rapid intracellular decay in ovine but not in Culicoides cells and to the attenuation of BTV virulence in a mouse model of disease. Overall, our data reveal that the genetic variability of Seg-10/NS3 differentially modulates BTV replication kinetics in a host-specific manner and highlight the role of the host-specific variation in NS3 protein turnover rate. IMPORTANCEBTV is the causative agent of a severe disease transmitted between ruminants by biting midges of Culicoides species. NS3, encoded by Seg-10 of the BTV genome, fulfills key roles in BTV infection. As Seg-10 sequences from various BTV strains display genetic variability, we assessed the impact of different Seg-10 and NS3 proteins on BTV infection and host interactions. In this study, we revealed that various Seg-10/NS3 proteins alter BTV replication kinetics in mammals but not in insects. Notably, we found that NS3 protein turnover may vary in ovine but not in Culicoides cells due to a single amino acid residue that, most likely, leads to rapid and host-dependent protein degradation. Overall, this study highlights that genetically distant BTV Seg-10/NS3 influence BTV biological properties in a host-specific manner and increases our understanding of how NS3 proteins contribute to the outcome of BTV infection. Bluetongue virus (BTV) is an arthropod-borne virus responsible for a hemorrhagic disease of domestic and wild ruminants (1, 2) and is transmitted between mammalian hosts by biting midges of the Culicoides family (3, 4). C. imicola represents the major vector species in Africa (3) and in southern Europe (5, 6), whereas C. obsoletus and C. pulicaris species have been involved in the transmission of BTV in central and northern Europe (7-9). The impact of bluetongue disease in Europe was relatively low before the 1990s (6, 10, 11). However, since 1998, several seasonal incursions of distinct BTV serotypes/strains have occurred virtually every year, causing massive economic losses to animal husbandry (7,(12)(13)(14)(15)(16). BTV is a nonenveloped virus that belongs to the Orbi...

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“…BTV target cells are subependymal neuronal and glial precursor cells. Susceptible mouse strains include BALB/c [81] and type I IFN receptor-deficient mice [82,83], but no BTV mouse model of TPT is reported.…”

Section: Btvmentioning

confidence: 99%

Neuroteratogenic Viruses and Lessons for Zika Virus Models

Kim

Shresta

2016

Trends in Microbiology

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The Centers for Disease Control and Prevention has confirmed that Zika virus (ZIKV) causes congenital microcephaly. ZIKV now joins five other neuroteratogenic (NT) viruses in humans and ZIKV research is in its infancy. In addition, there is only one other NT human arbovirus (Venezuelan equine encephalitis virus), which is also poorly understood. But further insight into ZIKV can be found by evaluating arboviruses in domestic animals, of which there are at least seven NT viruses, three of which have been well studied. Here we review two key anatomical structures involved in modeling transplacental NT virus transmission: the placenta and the fetal blood-brain barrier. We then survey major research findings regarding transmission of NT viruses for guidance in establishing a mouse model of Zika disease that is crucial for a better understanding of ZIKV transmission and pathogenesis.

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A review of experimental infections with bluetongue virus in the mammalian host

Cited by 37 publications

References 134 publications

Bluetongue Virus in wild ruminants in Europe: Concerns and facts, with a brief reference to bluetongue in cervids in Greece during the 2014 outbreak

Bluetongue Virus in wild ruminants in Europe: Concerns and facts, with a brief reference to bluetongue in cervids in Greece during the 2014 outbreak

Turnover Rate of NS3 Proteins Modulates Bluetongue Virus Replication Kinetics in a Host-Specific Manner

Neuroteratogenic Viruses and Lessons for Zika Virus Models

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