A review of fiber-optic biosensors

Leung, Angela M.; Shankar, P.M.; Mutharasan, Raj

doi:10.1016/j.snb.2007.03.010

Cited by 622 publications

(390 citation statements)

References 79 publications

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“…Optical fibers also offer a great potential for increased sensitivity through long interaction lengths, provided optical losses can be managed [12]. However, to facilitate interaction of the light propagating in the fiber core with the analyte for use in biosensing, chemical etching [13] or tapering [14] typically has to be carried out on the fibers, leading to inferior mechanical properties. More advanced designs of optical fibers such as photonic crystal fiber [15] or suspended core microstructured fiber [12,16] can allow direct interaction of the light in the fiber core with the analyte solution flowing through the air-holes running along the fiber core.…”

Section: Introductionmentioning

confidence: 99%

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Nguyen

Hill

Warren‐Smith

et al. 2015

Sensors and Actuators B: Chemical

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In all cases accepted manuscripts should:  link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article Abstract: This work presents a novel biosensor using the multimode interference effect in an exposed core microstructured optical fiber (ECF). In this work biotin molecules are immobilized onto the ECF core surface to serve as the capturing probe for streptavidin, the target molecules.Since each distinct guided mode in the ECF interacts with the surrounding medium differently, the interference between any two specific modes will experience a fringe shift (or phase change) upon a change in the refractive index (RI) of the surrounding medium, or a localized RI change on the surface of the ECF core as a result of a biological binding event. In our experiment, the interferometric sensing platform was realized by splicing a section of ECF with lead-in and leadout single mode fibers (SMFs). An interference pattern is obtained in the transmission spectrum as the result of multiple excited modes (excited and re-collected at the lead-in and lead-out splicing points) propagating in the ECF with different propagation constants. The interference pattern is non-uniform, indicating that there are more than two modes involved. Fast Fourier transform (FFT) is used to separate individual interference patterns that contribute to this complex spectrum and monitor their phase changes upon RI variation of the surrounding medium. In this way multiple RI sensitivities can be realized because each spatial frequency possesses a distinct sensitivity with respect to the surrounding RI. The operation of this device was validated by measuring the phase changes that occur when the sensing platform was subjected to solutions of different RIs or functionalized with different molecules. A biosensor was demonstrated based on this novel platform using biotin as the capturing probe to detect streptavidin with low non-specific adsorption. The proposed platform is reliable, cost-effective, and offers a potential label-free biosensing alternative to the widely used surface plasmon resonance (SPR) technique.

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Section: Introductionmentioning

confidence: 99%

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Nguyen

Hill

Warren‐Smith

et al. 2015

Sensors and Actuators B: Chemical

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“…Geometric parameters play a critical role in exposing the evanescent field to interact with samples. Basic principles and common geometries of tapered fiber-optic biosensors were reviewed by Leung et al (2007) and detailed account of their use for detection of biomolecules was presented. Bosch et al (2007) also presented an exhaustive review of fiber optic biosensors in terms of detection phenomena used viz.…”

Section: Classification Of Fiber Optic Biosensorsmentioning

confidence: 99%

Optical biosensors for food quality and safety assurance—a review

et al. 2011

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Food quality and safety is a scientific discipline describing handling, preparation and storage of food in ways that prevent food borne illness. Food serves as a growth medium for microorganisms that can be pathogenic or cause food spoilage. Therefore, it is imperative to have stringent laws and standards for the preparation, packaging and transportation of food. The conventional methods for detection of food contamination based on culturing, colony counting, chromatography and immunoassay are tedious and time consuming while biosensors have overcome some of these disadvantages. There is growing interest in biosensors due to high specificity, convenience and quick response. Optical biosensors show greater potential for the detection of pathogens, pesticide and drug residues, hygiene monitoring, heavy metals and other toxic substances in the food to check whether it is safe for consumption or not. This review focuses on optical biosensors, the recent developments in the associated instrumentation with emphasis on fiber optic and surface plasmon resonance (SPR) based biosensors for detecting a range of analytes in food samples, the major advantages and challenges associated with optical biosensors. It also briefly covers the different methods employed for the immobilization of bio-molecules used in developing biosensors.

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“…The geometric design of optical platforms is a key point to achieve efficient and integrated optical immunosensors. There are several geometric layouts, the most usual being strips, waveguide fibers (Leung et al, 2007), planar optical waveguide systems, capillary sensors, and arrays. Planar waveguide systems are especially attractive because of the possibility of innovative designs and the integration of multiple functionalities onto a single sensor.…”

Section: Optical Immunosensorsmentioning

confidence: 99%