A review of free radicals and antioxidants for critical care nurses

Scheibmeir, Heath D.; Christensen, Katie; Whitaker, Sally H.; Jegaethesan, Jay; Clancy, Richard L.; Pierce, Janet D.

doi:10.1016/j.iccn.2004.07.007

Cited by 72 publications

(45 citation statements)

References 31 publications

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“…The increased levels of ascorbic acid and ceruloplasmin found in this study indicate intact oxidant defense mechanism, as they can act as freeradical scavengers [18]. Zwołińska et al [19] observed significantly raised levels of plasma and erythrocyte MDA and reduced zinc, copper, and selenium concentrations in patients with chronic renal failure in predialysis phase when compared with controls.…”

Section: Discussionsupporting

confidence: 54%

Antioxidant status of children with acute renal failure

et al. 2008

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The production of free radicals can cause renal injury and play a role in the pathogenesis of acute renal failure (ARF). The indirect markers of reactive oxygen species (ROS) were evaluated in children with ARF and controls. Forty patients with ARF aged 0-10 years were selected. Twenty age- and gender-matched healthy children were included as controls. Plasma malondialdehyde, protein carbonyl, nitrite, copper, ascorbic acid, zinc, and ceruloplasmin levels were estimated in patients with ARF and controls. The plasma malondialdehyde (p < 0.01), copper (p < 0.001), ascorbic acid (p < 0.05), and ceruloplasmin (p < 0.001) levels were significantly raised in ARF patients in comparison with controls. Significantly higher levels of plasma malondialdehyde (p < 0.01), nitrite (p < 0.001), copper (p < 0.001), and ceruloplasmin (p < 0.001) and lower plasma zinc (p < 0.01) were found in ARF nonsurvivors in comparison with survivors. The cutoff levels of plasma nitrite and ceruloplasmin were found to be most accurate in predicting mortality in ARF patients and had maximum sensitivity (100%) and specificity (60.7%) among the parameters studied. In conclusion, the increased levels of oxidants and antioxidants suggest the production of ROS and their possible role in ARF pathogenesis. Plasma nitrite and ceruloplasmin concentrations demonstrated predictive ability in relation to mortality.

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Section: Discussionsupporting

confidence: 54%

Antioxidant status of children with acute renal failure

et al. 2008

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“…Antioxidants can modulate cellular oxidative status and reduce the risk of these diseases and health problems [4][5][6]. Many previous researches demonstrated that wheat grain contained significant level of natural antioxidants [3,[7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Distribution of Phenolic Acids and Antioxidant Activities of Different Bran Fractions from Three Pigmented Wheat Varieties

Zhang

Ding

Dong

et al. 2018

Journal of Chemistry

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Phenolic acid profiles and antioxidant activities of outer bran, coarse bran, and shorts from blue, black, and purple wheat were analyzed. Phenolic acids were mainly in the bound form in pigmented wheat bran fractions. Phenolic acid content decreased in the order of outer bran, coarse bran, and shorts for the three pigmented wheat varieties. HPLC analysis of phenolic extracts demonstrated that the bound form of phenolic acids contained more ferulic, isoferulic, and p-coumaric acids compared to their free counterparts. Among the three pigmented wheat varieties, the bran fractions from blue wheat contained higher bound phenolic acids than the other two pigmented wheat bran fractions, except for purple coarse bran. The blue wheat outer bran had the highest total bound phenolic acid of 3458.71 g/g while the purple wheat shorts had the lowest of 1730.71 g/g. The contribution of bound phenolic acids to the total phenolic content and antioxidant activity was significantly higher than that of free phenolic acids. Blue wheat bran fractions had the highest radical scavenging activity against DPPH• while those of purple wheat gained the highest ABTS•+ scavenging activity. High correlations were observed between TPC and radical scavenging capacities for DPPH and ABTS ( 2 > 0.85, < 0.05).

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“…In the normal oxidative metabolism, the FORs are formed in small quantities and can be removed effectively by natural defense mechanisms. Oxidative stress occurs whenever there are more free oxygen radicals than can be destroyed [4]. Antioxidants are compounds known to react with FORs, inactivating them and thus preventing their cell-damaging action [5].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Assay to Quantify the Hydroxyl Radical Scavenging Activity of Medicinal Plant Extracts

et al. 2010

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A new electrochemical assay has been developed which is based on quantifying the attack of OH. radicals on a selfassembled thiol monolayer on electrodes in the presence and absence of antioxidants. The OH . radicals were produced in Fenton solutions. The radical scavengers diminish the concentration of the OH . radicals in the Fenton solution, and the extent of thiol layer destruction is monitored with the help of a redox probe in solution, the signal of which is only generated at SAM-free electrode surface. The results of the electrochemical assay were compared with those of the standard DPPH . assay. In case of each plant extract, an excellent linear correlation was observed between the radical scavenging activity and the concentration of plant extracts; however, the scavenging properties of different plants strongly differ in the electrochemical and the DPPH . assay. Since the proposed new method probes the reactivity of radical scavengers towards OH . , one of the most important reactive oxygen radicals in tissues, it is supposed to provide much more relevant information than the DPPH . or other assays.

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A review of free radicals and antioxidants for critical care nurses

Cited by 72 publications

References 31 publications

Antioxidant status of children with acute renal failure

Antioxidant status of children with acute renal failure

Distribution of Phenolic Acids and Antioxidant Activities of Different Bran Fractions from Three Pigmented Wheat Varieties

Electrochemical Assay to Quantify the Hydroxyl Radical Scavenging Activity of Medicinal Plant Extracts

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