A Review of Gastric Cancer Research in Malaysia

Lim, Kean Ghee; Palayan, Kandasami

doi:10.31557/apjcp.2019.20.1.5

Cited by 24 publications

(36 citation statements)

References 31 publications

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“…Among the European and Asian continents, Slovakia and Republic of Korea have the highest incidence rates irrespective of gender. Variations in lifestyle habits coupled with genetic disorders such as FAP and Lynch syndrome result in the increased risk of developing CRC . Moreover, studies have attributed infectious agents as an etiological agent in the development of 20% of cancers worldwide .…”

Section: K Pneumoniae‐associated Diseases Of the Lower Gitmentioning

confidence: 99%

“…Variations in lifestyle habits coupled with genetic disorders such as FAP and Lynch syndrome result in the increased risk of developing CRC. 4 Moreover, studies have attributed infectious agents as an etiological agent in the development of 20% of cancers worldwide. 5,7 K. pneumoniae is one probable bacterium that may play a role in development of CRC.…”

Section: K Pneumoniae-associated Diseases Of the Lower Gitmentioning

confidence: 99%

“…On the other hand, environmental factors such as stress and frequent travel could also increase the risk of developing GIT diseases . In addition, certain lifestyle factors such as smoking, consumption of alcohol, imbalance in diet (diets with low fiber intake), obesity and lack of exercise are compounding factors that play a role in the development of progression of GIT diseases . Aside from the aforementioned factors, studies in the past decade have highlighted the role of infectious agents in GIT disease development .…”

Section: Introductionmentioning

confidence: 99%

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Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases

Kaur

Vadivelu

Samudi

2018

J of Digest Diseases

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The 2016 Global Burden of Disease report by WHO revealed that diseases of the gastrointestinal tract (GIT) had one of the highest incidence rates worldwide. The plethora of factors that contribute to the development of GIT-related illnesses can be divided into genetic, environmental and lifestyle factors. Apart from that, the role that infectious agents play in the development of GIT diseases has piqued the interest of researchers worldwide. The human gut harbors approximately 10 bacteria in it with increasing concentration toward the lower GIT. Among the various microbiota that colonize the human gut, Gram-negative bacteria have been most notoriously linked to GIT-related diseases such as inflammatory bowel disease (IBD) including Crohn's disease and ulcerative colitis and colorectal cancer (CRC). Some of the notable culprits that have been attributed to these diseases are Bacteroides fragilis, Fusobacterium nucleatum, Escherichia coli and Helicobacter pylori. However, studies in recent years are beginning to recognize a new player, Klebsiella pneumoniae (K. pneumoniae) in the causation and progression of GIT diseases. Once synonymous with infections and diseases of the upper respiratory tract, K. pneumoniae has now emerged as one of the pathogens commonly isolated from patients with GIT diseases. However, extensive studies attributing K. pneumoniae to GIT diseases, particularly that of CRC are scanty. Therefore, this review intends to shed light on the association of K. pneumoniae in gastrointestinal diseases such as Crohn's disease, ulcerative colitis as well as CRC.

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Section: K Pneumoniae‐associated Diseases Of the Lower Gitmentioning

confidence: 99%

Section: K Pneumoniae-associated Diseases Of the Lower Gitmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases

Kaur

Vadivelu

Samudi

2018

J of Digest Diseases

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“…Meanwhile, the prevalence of overweight and obesity were found to be 33.6% and 19.5% respectively in Malaysia [8]the prevalence of overweight and obesity were found to be 33.6% (95% CI=32.2, 35.0. Overweight and obesity appear as the major cause of non-communicable diseases, including cardiovascular disease, hypertension, type 2 diabetes mellitus, dyslipidemia, gallbladder disease, musculoskeletal disorders such as osteoarthritis and also some cancers [9]. Thus, the growing problem of overweight and obesity in Malaysians should be taken earnestly as it can burden the health care systems and lower the quality of life.…”

Section: Introductionmentioning

confidence: 99%

Association between screen time and body mass index among university students

Kalirathinam

Hui

Jacob

et al. 2019

Sci Med

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AIMS: Screen time has been proven to be associated with overweight and obesity among pediatric. However, the relationship between these two variables has not been confirmed among university students in Malaysia who are having increasing screen time. Hence, this study is conducted to examine the association between screen time and body mass index (BMI) among university students. METHODS: A total of 390 university students (female=236, male=154) with a mean age of 20.17 years old were involved in this study. They completed the Screen Time Based Sedentary Behaviour Questionnaire for total screen time assessment. Body height and weight were measured to calculate body mass index (BMI). RESULTS: Prevalence of overweight and obesity were not high among university students (12.3% and 4.4%). Male subjects have generally higher BMI compared to female subjects. The smartphone was the most common device owned by subjects (33%). The screen time of subjects was high as there were 97.4% of subjects fell under the category of high screen time (> 2 hours). However, screen time was not significantly associated with BMI (p=0.36). The only variable which associated with screen time was the devices owned by subjects (p=0.001). CONCLUSIONS: Screen time was not significantly associated with BMI among university students. Future study should include the relationship of other factors on BMI among university students. KEYWORDS: Screen time; body mass index. RESUMOOBJETIVOS: Foi demonstrado que o tempo de tela está associado ao sobrepeso e à obesidade nos pacientes pediátricos. No entanto, a relação entre essas duas variáveis não foi confirmada entre estudantes universitários na Malásia, que estão tendo um aumento no tempo de tela. Desse modo, o objetivo desses estudo é avaliar a associação entre tempo de tela e o indice de maasa corporal (IMC) entre estudantes universitários. MÉTODOS: Um total de 390 estudantes universitários (sexo feminino=236, masculino=154) com idade média de 20,17 anos foram envolvidos neste estudo. Eles completaram o Questionário de Comportamento Sedentário Baseado no Tempo de Tela para avaliação total do tempo de tela. A altura corporal e o peso foram medidos para calcular o índice de massa corporal (IMC). RESULTADOS: A prevalência de sobrepeso e obesidade não foi alta entre os universitários (12,3% e 4,4%). Indivíduos do sexo masculino têm geralmente um IMC mais alto em comparação com indivíduos do sexo feminino. O smartphone foi o dispositivo mais comum de propriedade dos sujeitos (33%). O tempo de tela dos participantes foi alto, pois 97,4% dos sujeitos caíram na categoria de tempo de tela alta (> 2 horas). No entanto, o tempo de tela não foi significativamente associado ao IMC (p=0,36). A única variável associada ao tempo de tela foram os dispositivos pertencentes aos sujeitos (p=0,001). CONCLUSÕES: O tempo de tela não foi significativamente associado com o IMC entre os estudantes universitários. Estudos futuros devem incluir a relação de outros fatores sobre o IMC entre estudantes universitários. DESCRITORES: T...

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“…However, these individual studies reported inconsistently. Previous reviews in telomere sizes in cancer have reported CRC as a part [6–8], or were narrative reviews [9, 10]. Human telomere length vary with age or cell types [11] and animal models have shown that this may have diverse effects in various organ systems [12].…”

Section: Introductionmentioning

confidence: 99%

Association between telomere length and the risk of colorectal cancer: a meta-analysis of observational studies

et al. 2017

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BackgroundHuman chromosomes are capped and stabilized by telomeres. Telomere length regulates a ‘cellular mitotic clock’ that defines the number of cell divisions and hence, cellular life span. This study aimed to synthesize the evidence on the association between peripheral blood leucocytes (PBL) telomere length and the risk of colorectal cancer (CRC).MethodsWe searched relevant studies in electronic databases. When two or more observational studies reported the same outcome measures, we performed pooled analysis. All the analyses were performed on PBL using PCR. The odds ratio (OR) and its 95% confidence interval (CI) were used to assess the strength of association.ResultsSeven studies (with 8 datasets) were included in this meta-analysis; 3 prospective studies, 3 retrospective studies and 1 study with a separate prospective and retrospective designs. The pooled analysis of 4 prospective studies (summary OR 1.01, 95% CI: 0.77–1.34, I 2:30%) and 4 retrospective studies (summary OR 1.65, 95% CI: 0.96–2.83, I 2:96%) showed no relationship between PBL telomere length and the CRC risk. A subgroup analysis of 2 prospective studies exclusively on females also showed no association between PBL telomere length and the CRC risk (summary OR, 1.17, 95% CI:0.72–1.91, I 2:57%).ConclusionThe current analysis is insufficient to provide evidence on the relationship between PBL telomere length and the risk of CRC. Findings suggest that there may be a complex relationship between PBL telomere length and the CRC risk or discrepancy between genetics, age of patients and clinical studies. Future well powered, large prospective studies on the relationship between telomere length and the risk of CRC, and the investigations of the biologic mechanisms are recommended.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2997-3) contains supplementary material, which is available to authorized users.

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A Review of Gastric Cancer Research in Malaysia

Cited by 24 publications

References 31 publications

Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases

Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases

Association between screen time and body mass index among university students

Association between telomere length and the risk of colorectal cancer: a meta-analysis of observational studies

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