A review of highly sensitive electrochemical genosensors for microRNA detection: A novel diagnostic platform for neurodegenerative diseases diagnostics

Abstract

The significant role of microRNAs in regulating gene expression and in disease tracking has handed the possibility of robust and accurate diagnosis of various diseases. Measurement of these biomarkers has also had a significant impact on the preparation of natural samples. Discovery of miRNAs is a major challenge due to their small size in the real sample and their short length, which is generally measured by complex and expensive methods. Electrochemical nanobiosensors have made significant progress in this field. Due to the delicate nature of nerve tissue repair and the significance of rapid‐fire feature of neurodegenerative conditions, these biosensors can be reliably promising. This review presents advances in the field of neurodegenerative diseases diagnostics. At the same time, there are still numerous openings in this field that are a bright prospect for researchers in the rapid‐fire opinion of neurological diseases and indeed nerve tissue repair.

Designing a Simple Electrochemical Genosensor for the Detection of Urinary PCA3, a Prostate Cancer Biomarker

“…These devices are highly desirable for their ability to provide sequence-specific information in a faster, simpler, and less costly manner than conventional assays such as PCR or RT-PCR. Genosensors find application across a diverse array of fields, including but not limited to the following: neurodegenerative diseases [19,20]; cancerous pathologies encompassing breast cancer [21][22][23], cervical cancer [24,25], gastric cancer [26,27] and colorectal cancer [28]; inherited diseases like coronary artery diseases [29,30], sickle cell anemia [31] and thalassemia [32,33]; and the detection of infectious pathogens (SARS-CoV-2 [34,35], Influenza A virus [36,37], Haemophilus influenza [38], and Mycobacterium tuberculosis [39,40]).…”