A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

Abstract

The consequence of CSE or 3MST inhibition in cancer cells need to be examined in the future. Better portrayal of the crosstalk among these gaseous transmitters may not only lead to an in-depth understanding of cancer progression but also shed light on novel strategies for cancer therapy. Antioxid. Redox Signal. 00, 000-000.

Selenosulfides Tethered to gem‐Dimethyl Esters: A Robust and Highly Versatile Framework for H2S Probe Development

“…Hydrogen sulfide (H 2 S), once regarded as merely a toxic and foul‐smelling gas, has recently been recognized as an endogenous signaling molecule and important physiological mediator within mammalian systems . Although several H 2 S‐regulated processes have been discovered in recent years, questions surrounding its metabolism, distribution, and prevalence still persist.…”

“…With the sulfur half being nonessential to its high reactivity ands electivity towards H 2 S, we highlight the unique flexibility of our design by improving its biocompatibility and tissue specificity through structuralmodifications of its sulfide moiety.Hydrogen sulfide (H 2 S), once regarded as merely at oxic and foul-smelling gas, has recently been recognized as an endogenous signaling molecule and important physiological mediator within mammalian systems. [1][2][3] Althoughs everalH 2 S-regulated processes have been discovered in recent years, questions surrounding its metabolism, distribution, and prevalence still persist. Therefore, the development of new bioanalytical methods for probingt he biological signaling pathways of H 2 Si sn eeded to betterd iscerni ts primarya nd secondary roles as as ignaling molecule.…”

The In Situ Sulfidation of Cu2O by Endogenous H2S for Colon Cancer Theranostics

“…Hydrogen sulfide (H 2 S), which has been proven to have many important biological functions in health and disease, plays an important role in colon cancer, with concentrations ranging from 0.3 to 3.4 mmol L −1 . Owing to the selectively up‐regulation of the H 2 S‐producing enzyme cystathionine‐β‐synthase (CBS) of colon cancer, the concentration of H 2 S in cancer tissue is much higher than that in the non‐cancerous peritumor tissue . By utilizing the high‐expression endogenous H 2 S as trigger, several H 2 S activated fluorescence probes have been developed with high sensitivity for the diagnosis of colon cancer .…”

Multifluorinated Aryl Azides for the Development of Improved H2S Probes, and Fast Strain‐promoted Azide‐Alkyne Cycloaddition and Staudinger Reactions

“…Dysregulation of H 2 S levels in vivo is correlated with numerous diseases including cancers. [31] Therefore, a tool capable of detecting endogenous H 2 S in situ and real-time needs to be developed, and H 2 S fluorescent probes (1979)(1980)(1981)(1982)(1983), MS in Organometallic Chemistry from Nankai University (1985)(1986)(1987)(1988), PhD in Bioorganic Chemistry from Uppsala University (Sweden) under the supervision of Professor Jyoti Chattopadhyaya (1990Chattopadhyaya ( -1994.…”