A review of improved fixation methods for dental implants. Part I: Surface optimization for rapid osseointegration

Shibata, Yo; Tanimoto, Yasuhiro

doi:10.1016/j.jpor.2014.11.007

Cited by 124 publications

(83 citation statements)

References 105 publications

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“…The outcomes of the mechanical marrow ablation model are reproducible and applicable to the study of intramembranous bone regeneration 3,4,16 and bone-implant fixation in orthopedic 9,18,19 and dental 22,23 applications. As a technique with a bone regeneration end point (Figure 4), the marrow ablation model induces trabecular bone formation within the intramedullary canal in regions that, under normal conditions, lack trabecular bone.…”

Section: Discussionmentioning

confidence: 96%

“…The marrow ablation model is primarily used for two main purposes: (1) as a model for intramembranous bone regeneration 3,4,16,17 and (2) as a model to study implant fixation in orthopedics 9,[18][19][20][21] and dentistry. 22,23 Therefore, the model is of interest to orthopedic and dental research, including biomaterial specialists, implant designers and molecular biologists as well as the field of regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

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Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models

et al. 2016

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In this paper, we provide a detailed protocol for a model of long bone mechanical marrow ablation in the rodent, including surgical procedure, anesthesia, and pre-and post-operative care. In addition, frequently used experimental end points are briefly discussed. This model was developed to study intramembranous bone regeneration following surgical disruption of the marrow contents of long bones. In this model, the timing of the appearance of bone formation and remodeling is well-characterized and therefore the model is well-suited to evaluate the in vivo effects of various agents which influence these processes. When biomaterials such as tissue engineering scaffolds or metal implants are placed in the medullary cavity after marrow ablation, end points relevant to tissue engineering and implant fixation can also be analyzed. By sharing a detailed protocol, we hope to improve inter-laboratory reproducibility.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models

et al. 2016

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“…Indeed, the topography of the implant promotes contact between cell components and molecular bio-guests and the surface of the implant during osseointegration [2,16,17,18]. According to J. Sternad [9,10,13,19,20], roughness, surface chemistry and surface treatment of implants has a great impact on the bone-implant interface. Many current research focuses on changes of surface topography of implant materials to improve osseointegration [2,3,18].…”

Section: Discussion:-mentioning

confidence: 99%

“…The exact role of the surface topography of implants on the early stages of osseointegration of dental implants remains poorly understood. In addition, comparative clinical studies with different implant surfaces are rarely performed [13,20]. The originality of this study is that it is carried by two types of studies in vitro and in vivo for the first assessment biorectivity and cytotoxicity of titanium alloy implants (Ti6A14V), which pose still some problems osseointegration and then to improve osseointegration of titanium alloy implants with a coating of Diamond -Like Carbon (DLC).…”

Section: Discussion:-mentioning

confidence: 99%

The Improvement of Biocompatibility of the Dental Titanium Alloy Implants With DLC Coating:in Vitro and in Vivo Study.

Sidqui¹

2017

IJAR

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Titanium alloys (Ti6A14V) are biomaterials of choice in dentistry, due totheir resistance to the biological constraints of the environment. Their use still causes in a number of cases, problems of osseointegrationthat urge us to raise again the question of the interface of titanium alloys withmineralized tissues in particular. The purpose of this study isfirst to evaluate the biocompatibility of these implants in the biological medium while offering alternative proposals for improving the osseointegration of these implants. Two studies were first conducted for this evaluation: in vitro study on human fibroblast cell cultures and bacterial colonization in the presence of four bacterial strains (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Haemolytic streptococcus) with and without implants , in vivo study on Wistar wistarrats (n = 35) which consists in the implantation of the biomaterial at the gingival sulcus and the renal capsule ; procurement of target organs of the cytotoxicity (sulcus, kidney and liver) and their morphological study withan optical microscope. Our results showed that the implants of titanium alloy (Ti6A14V) indeed disrupt the cellular structure of the organs studied compared to controls. The proliferation of bacterial strains studied was substantially similar in culture plates with and without implants. The proliferation of human fibroblasts in cell culture showed no significant change between the implants pits and the control pits. We concluded that the implants of titanium alloy (Ti6A14V) were biocompatible in vitro but cause some problems in vivo. This could explain the negative impact of these implants on osseointegration. The surface of implantscouldbe a limiting factorfor the biocompatibility and the osseointegration of titanium alloys (Ti6A14V). We have then showed,with a similar histopathological study, that the coating of the implants of titanium

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“…Numerous reports have demonstrated that the roughness and chemistry of implant surfaces are important factors for improving osseointegration. [18][19][20] However, few studies have compared the role of the two factors in osseointegration. In this study, we prepared four surfaces that differ in roughness and chemistry and compared the effects of these surfaces on osseointegration via an in vitro cellular study and in vivo animal experiment.…”

mentioning

confidence: 99%

Effects of a micro/nano rough strontium-loaded surface on osseointegration

Li¹,

Qi²,

Gao³

et al. 2015

IJN

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We developed a hierarchical hybrid micro/nanorough strontium-loaded Ti (MNT-Sr) surface fabricated through hydrofluoric acid etching followed by magnetron sputtering and evaluated the effects of this surface on osseointegration. Samples with a smooth Ti (ST) surface, micro Ti (MT) surface treated with hydrofluoric acid etching, and strontium-loaded nano Ti (NT-Sr) surface treated with SrTiO 3 target deposited via magnetron sputtering technique were investigated in parallel for comparison. The results showed that MNT-Sr surfaces were prepared successfully and with high interface bonding strength. Moreover, slow Sr release could be detected when the MNT-Sr and NT-Sr samples were immersed in phosphate-buffered saline. In in vitro experiments, the MNT-Sr surface significantly improved the proliferation and differentiation of osteoblasts compared with the other three groups. Twelve weeks after the four different surface implants were inserted into the distal femurs of 40 rats, the bone–implant contact in the ST, MT, NT-Sr, and MNT-Sr groups were 39.70%±6.00%, 57.60%±7.79%, 46.10%±5.51%, and 70.38%±8.61%, respectively. In terms of the mineral apposition ratio, the MNT-Sr group increased by 129%, 58%, and 25% compared with the values of the ST, MT, and NT-Sr groups, respectively. Moreover, the maximal pullout force in the MNT-Sr group was 1.12-, 0.31-, and 0.69-fold higher than the values of the ST, MT, and NT-Sr groups, respectively. These results suggested that the MNT-Sr surface has a synergistic effect of hierarchical micro/nano-topography and strontium for enhanced osseointegration, and it may be a promising option for clinical use. Compared with the MT surface, the NT-Sr surface significantly improved the differentiation of osteoblasts in vitro. In the in vivo animal experiment, the MT surface significantly enhanced the bone-implant contact and maximal pullout force than the NT-Sr surface.

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A review of improved fixation methods for dental implants. Part I: Surface optimization for rapid osseointegration

Cited by 124 publications

References 105 publications

Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models

Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models

The Improvement of Biocompatibility of the Dental Titanium Alloy Implants With DLC Coating:in Vitro and in Vivo Study.

Effects of a micro/nano rough strontium-loaded surface on osseointegration

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