A review of microfluidic-based mixing methods

Li, Zhenghua; Zhang, Baoliang; Dang, Dan; Yang, Xieliu

doi:10.1016/j.sna.2022.113757

Cited by 55 publications

(29 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the non-activated superhydrophobic surfaces can provide reduced drag to flows as the liquid contacts low friction gasses as opposed to solid channel walls. This is an advantage over passive and active mixers in that no permanent embedded structures 49 (such as herringbone patterns or electrodes) interfere with the flow and increase the required pumping power. Furthermore, the controllable nature of a cavitation bubble’s position and the easily scalable bubble size (controlled by limiting the laser energy or optical density) may allow for localized, point mixing which is not feasible with acoustic excitation methods that typically utilize transducers that are larger than the whole microfluidic chip.…”

Section: Discussionmentioning

confidence: 99%

The effect of scalable PDMS gas-entrapping microstructures on the dynamics of a single cavitation bubble

Robles

Gonzalez-Parra

Cuando-Espitia

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The effect of gas-entrapping polydimethylsiloxane (PDMS) microstructures on the dynamics of cavitation bubbles laser-induced next to the PDMS surface is investigated and compared against the cavitation dynamics next to a flat smooth boundary. Local pressure gradients produced by a cavitation bubble cause the air pockets entrapped in the PDMS microstructures to expand and oscillate, leading to a repulsion of the cavitation bubble. The microstructures were fabricated as boxed crevices via a simple and scalable laser ablation technique on cast acrylic, allowing for testing of variable structure sizes and reusable molds. The bubble dynamics were observed using high speed photography and the surrounding flows were visualized and quantified using particle tracking velocimetry. Smaller entrapped air pockets showed an enhanced ability to withstand deactivation at three stand-off distances and over 50 subsequent cavitation events. This investigation provides insight into the potential to direct the collapse of a cavitation bubble away from a surface to mitigate erosion or to enhance microfluidic mixing in low Reynolds number flows.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of scalable PDMS gas-entrapping microstructures on the dynamics of a single cavitation bubble

Robles

Gonzalez-Parra

Cuando-Espitia

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

Section: Lab On a Chip Critical Reviewmentioning

confidence: 99%

“…A curved microchannel structure can stretch the fluid in the outer ring of the channel and folds the fluid in the inner ring. 87 Based on this, Luo fabricated two serpentine micromixers with foci on the Y -axis and X -axis. 88 According to the simulated and experimental results, they found that the foci of the designed channel on the X -axis exhibited a better mixing performance.…”

Section: Separation Strategiesmentioning

confidence: 99%

Latest advances and perspectives of liquid biopsy for cancer diagnostics driven by microfluidic on-chip assays

Xie

Wang

et al. 2023

Lab Chip

View full text Add to dashboard Cite

show abstract

“…[ 2 ] The cumulative comprehension of the behavior and control of fluid flow at the microscale allowed the rapid advancement of this area. [ 3 ] As a result, the state‐of‐the‐art integrates several review articles that explore concepts such as the fluidic behavior in a variety of devices, [ 4 ] the physics behind the fluid phenomena, [ 5 ] the fundamental kinematics of microparticles inside microchannels, [ 6 ] and the small‐scale mixing, [ 7 ] among others.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies

Cardoso

Castanheira

Lanceros‐Méndez

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical research based on biologically accurate screening approaches. Since establishing the 2D in vitro cell culture method, the scientific community has improved cell-based drug screening assays and models. Those advances result in more informative biochemical assays and the development of 3D multicellular models to describe the biological complexity better and enhance the simulation of the in vivo microenvironment. Despite the overall dominance of conventional 2D and 3D cell macroscopic culture methods, they present physicochemical and operational challenges that impair the scale-up of drug screening by not allowing a high parallelization, multidrug combination, and high-throughput screening. Their combination and complementarity with microfluidic platforms enable the development of microfluidics-based cell culture platforms with unequivocal advantages in drug screening and cell therapies. Thus, this review presents an updated and consolidated view of cell culture miniaturization's physical, chemical, and operational considerations in the pharmaceutical research scenario. It clarifies advances in the field using gradient-based microfluidics, droplet-based microfluidics, printed-based microfluidics, digital-based microfluidics, SlipChip, and paper-based microfluidics. Finally, it presents a comparative analysis of the performance of cell-based methods in life research and development to achieve increased precision in the drug screening process.

show abstract

A review of microfluidic-based mixing methods

Cited by 55 publications

References 125 publications

The effect of scalable PDMS gas-entrapping microstructures on the dynamics of a single cavitation bubble

The effect of scalable PDMS gas-entrapping microstructures on the dynamics of a single cavitation bubble

Latest advances and perspectives of liquid biopsy for cancer diagnostics driven by microfluidic on-chip assays

Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies

Contact Info

Product

Resources

About