A Review of Mitomycin Use in Ophthalmic Surgery: Clarification of Safety Standards for Patients and Hospital Personnel

Radke, Phillip M.; Bitrian, Elena; Kaufman, Stephen C.; Grajewski, Alana L.

doi:10.1007/s40135-016-0111-2

Cited by 1 publication

(1 citation statement)

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“… 6 A high concentration of MMC can inhibit the synthesis of RNA and protein. 7 As a typical periodic nonspecific drug, MMC has been widely applied in the treatment of digestive tract cancers, such as gastric, cervical, bladder and lung cancers. 8 , 9 However, due to the lack of tumor specificity, chemotherapy drugs not only kill tumor cells but also damage normal cells, thus shortening their circulation in blood compartments.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere as an Efficient Drug Carrier for Cancer Treatment

Zhang

et al. 2021

CMAR

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Background: This study aimed to evaluate the properties and functions of polysaccharidebased porous microsphere (PPM) for drug delivery, as well as its inhibitory effect on malignant tumors. Materials and Methods: PPM was prepared using the inverse emulsion polymerization method. FT-IR measurements were conducted to measure the wavenumber of PPM. Particle size distribution was tested with a particle analyzer, and surface morphologies of PPM were observed using a scanning electron microscope (SEM). Dialysis method, Cell Counting Kit-8 (CCK-8), and cell apoptosis analysis were adopted to evaluate the drug release, cytotoxicity and biocompatibility of mitomycin-C (MMC), respectively. Finally, an in vivo study was performed in C57BL/6 mice to confirm the function of MMC-loaded PPM on tumor growth. Results: FT-IR spectra proved the successful preparation of MMC-loaded PPM. PPM had an average size of 25.90 ± 0.34 μm and then increased to 30.10 ± 0.20 μm after drug loading. Under SEM, the surface morphology was lotus seedpod surface-like, with macropits on the surface and micropores in macropits. Compared with the free MMC group, MMC-loaded PPM exhibited a delayed drug release rate in a pH-dependent manner and higher cell viability. Flow cytometry results showed that the cell apoptosis in the PPM/MMC group was lower than that in the free MMC group. In vivo experiment revealed the inhibitory efficacy of MMC-loaded PPM on malignant tumors. Conclusion: In summary, MMC-loaded PPM exhibited favorable surface morphology, sustained drug release ability, nontoxicity and excellent biocompatibility, suggesting that PPM might be a potential drug carrier for tumor treatment.

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Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere as an Efficient Drug Carrier for Cancer Treatment

Zhang

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

A Review of Mitomycin Use in Ophthalmic Surgery: Clarification of Safety Standards for Patients and Hospital Personnel

Cited by 1 publication

References 59 publications

Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere as an Efficient Drug Carrier for Cancer Treatment

Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere as an Efficient Drug Carrier for Cancer Treatment

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